Response of the nonhuman primate to polychlorinated biphenyl exposure1

  • J. R. Allen
Part of the FASEB Monographs book series (FASEBM, volume 6)


The polychlorinated biphenyls (PCBs) have been used extensively for industrial purposes during the past 40 years. These compounds are extremely stable, not hydrolyzed by water, acid or alkali, and are able to withstand temperatures up to 650 C without disintegrating. These properties make them ideal for use in adhesives, paints, varnishes, printing inks, and as general fillers. Since they do not conduct electricity, they have found widespread use in electrical equipment such as transformers. However, it was only during the past decade that the health significance of these compounds in man and lower animals has been brought to public attention.


Nonhuman Primate Muscularis Mucosa Plasmic Reticulum Mixed Function Oxidase Arene Oxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



polychlorinated biphenyl




Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Allen, J. R., L. J. Abrahamson and D. H. Norback. Biological effects of polychlorinated biphenyls and triphenyls on the subhuman primate. Environ. Res. 6: 344, 1973.PubMedCrossRefGoogle Scholar
  2. 2.
    Allen, J. R., L. A. Carstens and L. J. Abrahamson. Responses of rats exposed to polychlorinated biphenyls for fifty-two weeks. I. Comparison of tissue levels of PCB and biological changes. Arch. Environ. Contam. Toxicol. In press.Google Scholar
  3. 3.
    Allen, J. R., L. A. Carstens, L. J. Abrahamson and R. J. Marlar. Response of rats and nonhuman primates to 2,5,2′,5′-tetrachlorobiphenyl. Environ. Res.9: 265, 1975.PubMedCrossRefGoogle Scholar
  4. 4.
    Allen, J. R., L. A. Carstens and D. A. Barsotti. Residual effects of short-term, low level exposure of nonhuman primates to polychlorinated biphenyls. Toxicol. Appl. Pharmacol 30: 440, 1974.PubMedCrossRefGoogle Scholar
  5. 5.
    Allen, J. R., L. A.Carstens and D. H.Norback. Biological effects of the polychlorinated biphenyls in non-human primates. Proceedings of the International Symposium on Recent Advances in the Assessment of the Health Effects of Environmental Pollution, World Health Organization. In press.Google Scholar
  6. 6.
    Allen, J. R., and D. A.Norback. Polychlorinated biphenyl and triphenyl induced mucosal hyperplasia in primates. Science 179: 498, 1973.PubMedCrossRefGoogle Scholar
  7. 7.
    Allen, J. R., D. H.Norback and I. C.Hsu. Tissue modifications in monkeys as related to absorption, distribution and excretion of polychlorinated biphenyls. Arch. Environ. Contam. Toxicol. 2: 86, 1974.PubMedCrossRefGoogle Scholar
  8. 8.
    Barsotti, D. A., and J. R.Allen. Effects of polychlorinated biphenyls on reproduction in the primate. Federation Proc 34: 338, 1975.Google Scholar
  9. 9.
    Bitman, J., H.S.Cecil and S. J. Harris. Biological effects of polychlorinated biphenyls in rats and quail. Environ. Health Persp. 1: 145, 1972.CrossRefGoogle Scholar
  10. 10.
    Good, C. K., and N. Pensky. Halowax acne; cutaneous eruptions in marine electricians due to certain chlorinated naphthalenes and diphenyls. Arch. Dermatol. Syphilol. 48: 215, 1943.Google Scholar
  11. 11.
    Hirayama, C., T. Irisa and T. Yama-Moto. Fine structural changes of the liver in patients with chlorobiphenyl intoxication. Fukuoka Igaku Zasshi 60: 455, 1969.Google Scholar
  12. 12.
    Hsu, I. C., J. P. Van Miller and J. R. Allen. Metabolic fate of 3H 2,5,2′,5′-tetrachlorobiphenyl in nonhuman primates. Bull Environ. Contam. Toxicol. 14: 233, 1975.PubMedCrossRefGoogle Scholar
  13. 13.
    Hutterer, F., F. Schaffner, F. M. Klion and H. Popper. Hypertrophic, hypoactive smooth endoplasmic reticulum: A sensitive indicator of hepato-toxicity exemplified by dieldrin. Science 161: 1017, 1968.PubMedCrossRefGoogle Scholar
  14. 14.
    Jensen, S. Report on a new chemical hazard. New Sci 32: 612, 1966.Google Scholar
  15. 15.
    Jones, J. W., and H. S. Alden. An acneform dermatergosis. Arch. Dermatol. Syphilol. 33: 1022, 1936.CrossRefGoogle Scholar
  16. 16.
    Kolbye, A. C. Food exposure to polychlorinated biphenyls. Environ. Health Persp. 1: 85, 1972.CrossRefGoogle Scholar
  17. 17.
    Kuratsune, M. An epidemiologic study of “Yusho” or chlorobiphenyl poisoning. Fukuoka Igaku Zasshi 60: 513, 1969.Google Scholar
  18. 18.
    Kuratsune, M., T. Yoshimura, J. Matsuzaka and A. Yamaguchi. Epidemiologic study on Yusho, a poisoning caused by ingestion of rice oil contaminated with a commercial brand of polychlorinated biphenyls. Environ. Health. Persp. 1: 119, 1972.Google Scholar
  19. 19.
    Miller, J. A.Carcinogenesis by chemicals. Cancer Res 30: 559, 1970.PubMedGoogle Scholar
  20. 20.
    Okimura, M., C. Hirayama and M. Uzawa. Study of Yusho (chlorobiphenyl poisoning) in clinical examination. Fukuoka Igaku Zasshi 62: 123, 1971.Google Scholar
  21. 21.
    Van Miller, J. P., I. C. Hsu and J. R. Allen. Distribution and metabolism of 3H 2,5,2′,5′-tetrachlorobiphenyl in rats. Proc. Soc. Exptl. Biol. Med. 148: 682, 1975.Google Scholar
  22. 22.
    Yobs, A. R. Food exposure to polychlorinated biphenyls. Environ. Health Persp. 1: 79, 1972.CrossRefGoogle Scholar

Copyright information

© Federation of American Societies for Experimental Biology 1975

Authors and Affiliations

  • J. R. Allen
    • 1
  1. 1.Regional Primate Research Center, University of Wisconsin Medical School, and Food Research InstituteUniversity of WisconsinMadisonUSA

Personalised recommendations