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Effect of ambient levels of ozone on monkeys

  • D. L. Dungworth
  • W. L. Castleman
  • C. K. Chow
  • P. W. Mellick
  • M. G. Mustafa
  • B. Tarkington
  • W. S. Tyler
Part of the FASEB Monographs book series (FASEBM, volume 6)

Abstract

There is a considerable body of information concerning the experimental toxicity of ozone (16, 24), most of it relating to edemagenic concentrations above 1 ppm (2 mg/m3). Few descriptions have been provided of pulmonary lesions produced by concentrations of 0.8 ppm and below (3–6, 14, 15, 23), which represents the range of oxidant activity encountered in photochemical smog such as occurs in the California South Coast Basin (2). Our combined functional, biochemical and morphological studies of ozone toxicity are designed to provide information about the pathogenesis and nature of the effects of ozone at levels attained in smoggy environments.

Keywords

Rhesus Monkey Ozone Exposure Ambient Level Bronchiolar Epithelium Respiratory Bronchiole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Adamson, I. Y. R., and D. H. Bowden. The Type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen. Lab. Invest. 30: 35, 1974.PubMedGoogle Scholar
  2. 2.
    Basic Tabulation, California Air Monitoring Stations, California Air Resources Board, Sacramento, California, 1971.Google Scholar
  3. 3.
    Boatman, E. S., S. Sato and R. Frank. Acute effects of ozone on cat lungs. II. Structural. Am. Rev. Respirat. Diseases 110: 157, 1974.Google Scholar
  4. 4.
    Bruch, J., and H-W. Schlipköter. Veränderungen der Lungenalveolen bei der Maus nach chronischer Exposition mit Ozon in niedriger Konzentration. Virchows Arch. Pathol. Anat. 358: 355, 1973.CrossRefGoogle Scholar
  5. 5.
    Castleman, W., L., D. L. Dungworth and W. S. Tyler. Cytochemically detected alterations of lung acid phosphates reactivity following ozone exposure. Lab. Invest. 29: 310, 1973.PubMedGoogle Scholar
  6. 6.
    Castleman, W. L., D. L. Dungworth and W. S. Tyler. Histochemically detected enzymatic alterations in rat lung exposed to ozone. Exptl. Molec. Pathol. 19: 402, 1973.CrossRefGoogle Scholar
  7. 7.
    Castleman, W. L., D. L. Dungworth and W. S. Tyler. Intrapulmonary airway morphology in three species of monkeys. A correlated scanning and transmission electron microscopic study. Am. J. Anat. 142: 107, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Chow, C. K., C. J. Dillard and A. L. Tappel. Glutathione peroxidase system and lysozyme in rats exposed to ozone or nitrogen dioxide. Environ. Res. 7: 311, 1974.CrossRefGoogle Scholar
  9. 9.
    Chow, C. K., and A. L. Tappel. Activities of pentose shunt and glycolytic enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. Lipids 7: 518, 1972.PubMedCrossRefGoogle Scholar
  10. 10.
    Chow, C. K., and A. L. Tappel. An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. Lipids 7: 518, 1972.PubMedCrossRefGoogle Scholar
  11. 11.
    DeLucia, A. J., P. M. Hoque, M. G. Mustafa and C. E. Cross. Ozone interaction with rodent lung: Effect on sulfhydryls and sulfhydryl-containing enzyme activities. J. Lab. Clin. Med. 80: 559, 1972.PubMedGoogle Scholar
  12. 12.
    Dillard, C. J., N. Urribarri, K. Reddy, B. Fletcher, S. Taylor, B. de Lumen, S. Langberg and A. L. Tappel. Increased lysosomal enzymes in lungs of ozone-exposed rats. Arch. Environ. Health 25: 426, 1972.PubMedGoogle Scholar
  13. 13.
    Evans, M. J., L. J. Cabral, R. J. Stephens and G. Freeman. Renewal of alveolar epithelium in the rat following exposure to NO2. Am. J. Pathol. 70: 175, 1973.PubMedGoogle Scholar
  14. 14.
    Freeman, G., L. T. Juhos, N. J. Furiosi, R. Mussenden, R. J. Stephens and M. J. Evans. Pathology of pulmonary disease from exposure to interdependent ambient gases (nitrogen dioxide and ozone). Arch. Environ. Health 29: 203, 1974.PubMedGoogle Scholar
  15. 15.
    Freeman, G., R. J. Stephens, D. L. Coffin and J. F. Stara. Changes in dogs’ lungs after long-term exposure to ozone. Light and electron microscopy. Arch. Environ. Health 26: 209, 1973.PubMedGoogle Scholar
  16. 16.
    Jaffe, L. S. The biological effects of ozone on man and animals. Am. Ind. Hyg. Assoc. J. 28: 267, 1967.PubMedCrossRefGoogle Scholar
  17. 17.
    Lowrie, P. M., and W. S. Tyler. Selection and preparation of specific tissue regions for TE M using large erioxy-embedded blocks. 31st Ann. Proc. Electron Microscopy Soc. Amer., edited by C. J. Arceneaux. New Orleans, La. 1973.Google Scholar
  18. 18.
    Mittler, S., M. King and B. Burk-Hardt. Toxicity of ozone. III. Chronic toxicity. A.M.A. Arch. Ind. Health 15: 191, 1957.Google Scholar
  19. 19.
    Mustafa, M. G., and C. E. Cross. Effects of short-term ozone exposure on lung mitochondrial oxidative and energy metabolism. Arch. Biochem. Biophys. 162: 585, 1974.PubMedCrossRefGoogle Scholar
  20. 20.
    Mustafa, M. G., A. J. DeLucia, G. K. York, C. Arth and C. E. Cross. Ozone interaction with rodent lung. II. Effects on oxygen consumption of mitochondria. J.Lab. Clin. Med. 82: 357, 1973.PubMedGoogle Scholar
  21. 21.
    Nowell, J. A., and W. S. Tyler. Scanning electron microscopy of the surface morphology of mammalian lungs. Am. Rev. Respirat. Diseases 103: 313, 1971.Google Scholar
  22. 22.
    Scheel, L. D., O. J. Dobrogorski, J. T. Mountain, J. L. Svirbely and H. E. Stokinger. Physiologic, biochemical, immunologic and pathologic changes following ozone exposure. J. Appl. Physiol. 14: 67, 1959.PubMedGoogle Scholar
  23. 23.
    Stephens, R. J., M. F. Sloan, J. J. Evans and G. Freeman. Early response of lung to low levels of ozone. Am. J. Pathol. 74: 31, 1974.PubMedGoogle Scholar
  24. 24.
    Stokinger, H. E., and D. L. Coffin. Biologic effects of air pollutants. Air Pollution, 2nd ed., edited by A. C. Stern. New York: Academic, 1968, vol. 1, p. 445.Google Scholar
  25. 25.
    Stokinger, H. E. Evaluation of the hazards of ozone and oxides of nitrogen. Factors modifying toxicity. A.M.A. Arch. Ind. Health 15: 181, 1957.Google Scholar

Copyright information

© Federation of American Societies for Experimental Biology 1975

Authors and Affiliations

  • D. L. Dungworth
    • 1
  • W. L. Castleman
    • 1
  • C. K. Chow
    • 1
  • P. W. Mellick
    • 1
  • M. G. Mustafa
    • 1
  • B. Tarkington
    • 1
  • W. S. Tyler
    • 1
  1. 1.California Primate Research Center and Department of Veterinary PathologyUniversity of CaliforniaDavisUSA

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