Effect of ambient levels of ozone on monkeys
There is a considerable body of information concerning the experimental toxicity of ozone (16, 24), most of it relating to edemagenic concentrations above 1 ppm (2 mg/m3). Few descriptions have been provided of pulmonary lesions produced by concentrations of 0.8 ppm and below (3–6, 14, 15, 23), which represents the range of oxidant activity encountered in photochemical smog such as occurs in the California South Coast Basin (2). Our combined functional, biochemical and morphological studies of ozone toxicity are designed to provide information about the pathogenesis and nature of the effects of ozone at levels attained in smoggy environments.
KeywordsRhesus Monkey Ozone Exposure Ambient Level Bronchiolar Epithelium Respiratory Bronchiole
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