The issue of whether long-term frequent use of marihuana can lead to marked persistent changes in behavior and neuroendocrine function in man is still being debated. While the immediate short-term behavioral effects of the drug can be readily measured in a laboratory setting, the characterization of slowly-developing drug-induced changes in individually characteristic aspects of emotional and social behavior is more difficult. The nature of sample selection and the uncontrolled environmental variables in studies of chronic marihuana users versus nonusers have made the conclusions of such studies open to question.
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McIsaac, W. M., G. E. Fritchie, J. E. Idanpaan-Heikkila, B. T. Ho and L. F. Englert. Distribution of marihuana in monkey brain and concomitant behavioral effects. Nature 230: 593, 1971.PubMedCrossRefGoogle Scholar