Tetrahydrocannabinol-induced manifestations of the “marihuana syndrome” in group-living macaques

  • E. N. Sassenrath
  • L. F. Chapman
Part of the FASEB Monographs book series (FASEBM, volume 6)


The issue of whether long-term frequent use of marihuana can lead to marked persistent changes in behavior and neuroendocrine function in man is still being debated. While the immediate short-term behavioral effects of the drug can be readily measured in a laboratory setting, the characterization of slowly-developing drug-induced changes in individually characteristic aspects of emotional and social behavior is more difficult. The nature of sample selection and the uncontrolled environmental variables in studies of chronic marihuana users versus nonusers have made the conclusions of such studies open to question.


Alpha Male Plasma Testosterone Level Estrous Female Cage Group Dominance Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bowman, M., and R. O. Pihl. Cannabis: Psychological effects of chronic heavy use. Psychopharmacologia 29: 159, 1973.PubMedCrossRefGoogle Scholar
  2. 2.
    Campbell, A. M. G., J. L. G. Thompson, M. Evans and M. J. Williams. Cerebral atrophy in young cannabis smokers. Lancet 1: 202, 1972.PubMedCrossRefGoogle Scholar
  3. 3.
    Deneau, G. A., and S. Kaymakcalan. Physiological and psychological dependence to synthetic Δ9-tetrahydrocanna-binol (THC) in rhesus monkeys. Pharmacologist 13: 2, 1971.Google Scholar
  4. 4.
    Kolansky, H., and W. T. Moore. Toxic effects of chronic marihuana use. J. Am. Med. Assoc. 222: 35, 1972.CrossRefGoogle Scholar
  5. 5.
    Kolodny, R. C., W. H. Masters, R. M. Kolodner and J. Toro. Depression of plasma testosterone levels after chronic intensive marihuana use. N. Engl. J. Med. 290: 872, 1974.PubMedCrossRefGoogle Scholar
  6. 6.
    Maugh, T. H. Marihuana (II): Does it damage the brain? Science 185: 775, 1974.PubMedCrossRefGoogle Scholar
  7. 7.
    McIsaac, W. M., G. E. Fritchie, J. E. Idanpaan-Heikkila, B. T. Ho and L. F. Englert. Distribution of marihuana in monkey brain and concomitant behavioral effects. Nature 230: 593, 1971.PubMedCrossRefGoogle Scholar

Copyright information

© Federation of American Societies for Experimental Biology 1975

Authors and Affiliations

  • E. N. Sassenrath
    • 1
  • L. F. Chapman
    • 1
  1. 1.California Primate Research Center and Department of Behavioral BiologyUniversity of California School of MedicineDavisUSA

Personalised recommendations