Teratogenic effects of triamcinolone on the skeletal and lymphoid systems in nonhuman primates
Corticosteroids are used to treat several human diseases, especially allergies, and inflammatory, dermatologic and salt-imbalance conditions. Because of the possibility that treatment for one of these conditions might occur before a mother knows she is pregnant and that an effect may be exerted over a period of time which could encompass the organogenic or sensitive period, it is important to establish the teratogenic effect of these drugs. Walker (10, 11) has demonstrated that corticosteroids vary considerably in their teratogenic effects. Of the six corticosteroids tested he found triamcinolone to be one of the most teratogenic.
KeywordsRhesus Monkey Cleft Palate Triamcinolone Acetonide Teratogenic Effect Choanal Atresia
Unable to display preview. Download preview PDF.
- 5.Good, R. A.Hosp. Prac. 2: 38–53, 1967.Google Scholar
- 6.Hendrickx, A. G., R. H. Sawyer, B. L. Lasley and R. D. Barnes. Lab. Anim. Handb. 6: 305–315, 1975.Google Scholar
- 9.Nebel, L., and A. Ornoy. Advan.Exptl. Med. Biol. 27: 250–256, 1972.Google Scholar
- 11.Walker, B. E.Proc. Soc. Exptl. Biol. Med. 125: 1281–1284, 1967.Google Scholar
- 13.Wilson, J. G.Environment and Birth Defects. New York and London: Academic, 1973, p. 305.Google Scholar