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Electrical properties of the transverse tubular system

  • L. L. Costantin
Part of the Faseb Monographs book series (FASEBM, volume 5)

Abstract

The transverse tubular system (T-system) of skeletal muscle links surface membrane action potential and release of activator calcium from sarcoplasmic reticulum (SR). The spread of depolarization along this system has been studied in voltage-clamped frog muscle fibers by using the spread of contractile activation in a thin optical cross section through the fiber center as an index. In tetrodotoxin treated fibers as depolarization of the fiber is increased contraction spreads from superficial to axial myofibrils. In tetrodotoxin free fibers the radial gradient of activation is reversed indicating that normally the activating signal is propagated along the T-system. Activation across the SR-T tubule junction does not appear to trigger an all-or-none response from the SR.—Costantin, L. L. Electrical properties of the transverse tubular system. Federation Proc. 34: 1390–1394, 1975.

Keywords

Sarcomere Length Length Constant Radial Gradient Fiber Cross Section Tubular Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

T system

transverse tubular system

SR

sarcoplasmic reticulum

TTX

tetrodotoxin.

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References

  1. 1.
    Adrian, R. H., W. K. Chandler and A. L. Hodgkin. The kinetics of mechanical activation in frog muscle. J. Physiol London 204: 207, 1969.Google Scholar
  2. 2.
    Adrian, R. H., L. L. Costantin and L. D. Peachey. Radial spread of contraction in frog muscle fibers. J. Physiol London 204: 231, 1969.Google Scholar
  3. 3.
    Brown, L. M., H. Gonzalez-Serratos and A. F. Huxley. Electron microscopy of muscle fibers in extreme passive shortening. J. Physiol London 208: 86P, 1970.Google Scholar
  4. 4.
    Brown, L. M., H. Gonzalez-Serratos and A. F. Huxley. Electron microscopy of frog muscle fibers in extreme passive shortening. Abstr. XXV Intern. Congr. Physiol Sci. 243, 1971.Google Scholar
  5. 5.
    Costantin, L. L. The role of sodium current in the radial spread of contraction in frog muscle fibers. J. Gen. Physiol. 55: 703, 1970.CrossRefGoogle Scholar
  6. 6.
    Costantin, L. L., and S. R. Taylor. Active and passive shortening in voltage-clamped frog muscle fibers. J. Physiol. London 218: 13P, 1971.Google Scholar
  7. 7.
    Costantin, L. L., and S. R. Taylor. Graded activation in frog muscle fibers. J. Gen. Physiol. 61: 424, 1973.CrossRefGoogle Scholar

Copyright information

© Federation of American Societies 1975

Authors and Affiliations

  • L. L. Costantin
    • 1
  1. 1.Department of Physiology and BiophysicsWashington University School of MedicineSt. LouisUSA

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