Experimental models for the modification of human drug self-administration
Experimental studies of human ethanol self-administration are reviewed, and a description is provided of the procedural evolution that has occurred in the experimental study of the determinants of human ethanol self-administration. Human experimental models of alcoholism have been established within residential laboratories which permit chronic availability of ethanol to volunteer alcoholic subjects. Experimentation within such environments has progressed from observational and descriptive studies of experimental intoxication to studies that manipulate experimental variables so as to modify (reduce) ethanol self-administration by alcoholic subjects. To observe systematic effects of manipulated variables it has been necessary to develop sensitive baselines of ethanol self-administration. When ethanol intake has been relatively unrestricted, wide spontaneous fluctuations have made difficult the evaluation of manipulated variables. When a variety of restrictions on ethanol availability have been imposed, sensitive self-administration baselines have been established which have permitted the direct experimental assessment of some of the determinants of ethanol self-administration. Six methodological principles are suggested for enhancing the information yield of future research on the determinants of ethanol self-administration. The same general methodology is suggested for research with other varieties of drug self-administration.—Bigelow, G., R. Griffiths and I. Liebson. Experimental models for the modification of human drug self-administration: methodological developments in the study of ethanol self-administration by alcoholics. Federation Proc. 34: 1785-1792, 1975.
KeywordsDrinking Behavior Chronic Alcoholic Ethanol Intake Methodological Principle Manipulate Variable
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- 3.Bigelow, G., and I. Liebson. Cost factors controlling alcoholic drinking. Psychol. Rec. 22: 305, 1972.Google Scholar
- 13.Mcnamee, H. B., N. K. Mello and J. H. Mendelson. Experimental analysis of drinking patterns of alcoholics: Concurrent psychiatric observations. Am. j. Psychiatry 124: 1063, 1968.Google Scholar
- 15.Mello, N. K., H. B. Mcnamee and J. H. Mendelson. Drinking patterns of chronic alcoholics: Gambling and motivation for alcohol. In: Clinical Research in Alcoholism, edited by J. O. Cole. Washington, D. C.: Psychiatric Research Report No. 24, Am. Psychiatr. Assoc. 1968, p. 83.Google Scholar
- 18.Mendelson, J. H. (editor). Experimentally induced chronic intoxication and withdrawal in alcoholics. Q. J. Stud. Alcohol, Suppl. 2 1964.Google Scholar
- 19.Mendelson, J., J. Ladou and P. Solomon. Experimentally induced chronic intoxication and withdrawal in alcoholics: III. Psychiatric findings. Q. J. Stud. Alcohol, Suppl. 2 1964, p. 40.Google Scholar
- 21.Mendelson, J. H., N. K. Mello and P. Solomon. Small group drinking behavior: An experimental study of chronic alcoholics. The Addictive States, Res. Publ. Assoc. Res. Nerv. Ment. Dis. 46: 399, 1968.Google Scholar
- 24.Nathan, P., N. Zare, E. Ferneau and L. Lowenstein. Effects of congener differences in alcoholic beverages on the behavior of alcoholics. Q. J. Stud. Alcohol, Suppl. 5 1970, p. 87.Google Scholar
- 26.Sidman, M. Tactics of Scientific Research. New York: Basic Books, Inc. 1960.Google Scholar