Advertisement

Behavioral functions of narcotic antagonists: response-drug contingencies

  • James H. Woods
  • David A. Downs
  • John Carney
Part of the FASEB Monographs book series (FASEBM, volume 4)

Abstract

Behavioral effects of the narcotic antagonist naloxone are discussed in terms of stimulus functions. As an eliciting stimulus, the effects of naloxone depend on prior administration of narcotic. Administered independently of responding, naloxone can increase or decrease rates of narcotic-reinforced responding depending on the dose of naloxone. When naloxone is administered as a consequence of narcotic self-injection, the future probability of that behavior is reduced; thus, naloxone can function as a punishing stimulus. As a negatively-reinforcing stimulus, naloxone can maintain behavior which germinates or prevents delivery in morphine-dependent monkeys. In animals with previous naloxone avoidance-escape experience, unavoidable-inescapable injections of naloxone produce increases in avoidance-escape response rates. In these animals, responding subsequently can be maintained, at least temporarily, when naloxone is administered only as the consequence of responding.—Woods, J. H., D. A. Downs and J. Carney. Behavioral functions of narcotic antagonists: response-drug contingencies. Federation Proc. 34: 17771784, 1975.

Keywords

Behavioral Function Cumulative Record Abstinence Syndrome Naloxone Administration Drug Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Azrin, N. H., and W. C. Holz. In: Operant Behavior: Areas of Research and Application, edited by W. K. Honig. New York: Appleton-Century-Crofts, 1966, p. 380.Google Scholar
  2. 2.
    Balster, R. L., and C. R. Schuster. J. Exp. Anal. Behav. 20: 119, 1973.PubMedCrossRefGoogle Scholar
  3. 3.
    Barry, J. J., Jr., and J. M. Harrison. Psychol. Rep. 3: 3, 1957.Google Scholar
  4. 4.
    Byrd, L. D. J. Exp. Anal. Behav. 12: 1, 1969.PubMedCrossRefGoogle Scholar
  5. 5.
    Carney, J. Federation Proc. 32: 726, 1973.Google Scholar
  6. 6.
    Downs, D. A. and J. H. Woods. J. Pharmacol Exp. Ther. 191: 179, 1974.PubMedGoogle Scholar
  7. 7.
    Downs, D. A. and J. H. Woods. J. Exp. Anal. Behav. 23: 415, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Ferster, C. B., and B. F. Skinner. Schedules of Reinforcement. New York: Appleton-Century-Crofts, 1957.CrossRefGoogle Scholar
  9. 9.
    Gallistel, C. R. Psychol. Bull. 61: 23, 1964.PubMedCrossRefGoogle Scholar
  10. 10.
    Goldberg, S. R. J. Pharmacol. Exp. Ther. 186: 18, 1973.PubMedGoogle Scholar
  11. 11.
    Goldberg, S. R., F. Hoffmeister, U. Schlichting and W. Wuttke. J. Pharmacol. Exp. Ther. 179: 268, 1971.PubMedGoogle Scholar
  12. 12.
    Goldberg, S. R., and W. H. Morse. Pharmacologist 15: 236, 1973.Google Scholar
  13. 13.
    Goldberg, S. R., J. H. Woods and C. R. Schuster. J. Pharmacol. Exp. Ther. 176: 464, 1971.PubMedGoogle Scholar
  14. 14.
    Hoffmeister, F., and U. U. Schlichting. Psychopharmacologia 23: 220, 1972.CrossRefGoogle Scholar
  15. 15.
    Hoffmeister, F., and W. Wuttke. Psychopharmacologia 33: 247, 1973.PubMedCrossRefGoogle Scholar
  16. 16.
    Kaplan, M., B. Jackson and R. Sparer. J. Exp. Anal. Behav. 8: 321, 1965.PubMedCrossRefGoogle Scholar
  17. 17.
    Kelleher, R. T. In: Operant Behavior: Areas of Research and Application, edited by W. K. Honig. New York: Appleton-Century-Crofts, 1966, p. 160.Google Scholar
  18. 18.
    Kelleher, R. T., and W. H. Morse. J. Exp. Anal. Behav. 11: 819, 1968.PubMedCrossRefGoogle Scholar
  19. 19.
    Kelleher, R. T., and W. H. Morse. J. Exp. Anal. Behav. 12: 1063, 1969.PubMedCrossRefGoogle Scholar
  20. 20.
    Mckearney, J. W. J. Exp. Anal. Behav. 12: 301, 1969.PubMedCrossRefGoogle Scholar
  21. 21.
    Mckearney, J. W. Science 160: 1249, 1968.PubMedCrossRefGoogle Scholar
  22. 22.
    Mckearney, J. W. J. Exp. Anal. Behav. 14: 1, 1970.PubMedCrossRefGoogle Scholar
  23. 23.
    Mcmillan, D. E., P. S. Wolf and R. A. Carchman. J. Pharmacol. Exp. Ther. 175: 443, 1970.PubMedGoogle Scholar
  24. 24.
    Olds, J. Science 127: 315, 1958.PubMedCrossRefGoogle Scholar
  25. 25.
    Pickens, R., and T. Thompson. J. Pharmacol. Exp. Ther. 161: 122, 1968.PubMedGoogle Scholar
  26. 26.
    Powell, R. W., and G. Morris. J. Exp. Anal, Behav. 12: 149, 1969.CrossRefGoogle Scholar
  27. 27.
    Seevers, M. H., and G. A. Deneau. In: Physiological Pharmacology, edited by W. S. Root and F. G. Hoffman. New York: Academic, 1963, p. 565.Google Scholar
  28. 28.
    Skinner, B. F. The Behavior of Organisms: An Experimental Analysis. New York: Appleton-Century-Crofts, 1938.Google Scholar
  29. 29.
    Stretch, R., E. R. Orloff and G. J. Gerber. Can. J. Psychol. 24: 117, 1970.CrossRefGoogle Scholar
  30. 30.
    Trowill, J. A., J. Panksepp and R. Gandelman. Psychol. Rev. 76: 264, 1969.PubMedCrossRefGoogle Scholar
  31. 31.
    Vlllarreal, J. E., and M. G. Karbowski. In: Narcotic Antagonists, edited by M. C. Braude, L. S. Harris, E. L. May, J. P. Smith and J. E. Villarreal. New York: Raven, 1973, p. 273.Google Scholar
  32. 32.
    Way, E. L., H. H. Loh and F. H. Shen. J. Pharmacol. Exp. Ther. 167: 1, 1969.PubMedGoogle Scholar
  33. 33.
    Wlnograd, E. J. Exp. Anal. Behav. 8: 117, 1965.CrossRefGoogle Scholar
  34. 34.
    Woods, J. H., D. A. Downs and J. E. Villarreal. In: Psychic Dependence. Definition, Assessment in Animals and Man, edited by L. Goldberg and F. Hoffmeister. Berlin: Springer-Verlag, 1973, p. 114.Google Scholar
  35. 35.
    Woods, J. H., and C. R. Schuster. In: Stimulus Properties of Drugs, edited by T. Thompson and R. Pickens. New York: Appleton-Century-Crofts, 1971, p. 163.CrossRefGoogle Scholar
  36. 36.
    Woods, J. H., and C. R. Schuster. Int. J. Addict. 3: 231, 1968.Google Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • James H. Woods
    • 1
  • David A. Downs
    • 1
  • John Carney
    • 1
  1. 1.Department of PharmacologyUniversity of MichiganAnn ArborUSA

Personalised recommendations