Abstract
Many biological scientists have viewed attempts to study the psychological or behavioral aspects of drug action as belonging near the questionable limits of scientific inquiry, if not floating well into the abyss of the objectively unknowable. Such scientific conservatism is not without reason, for as Sidman (62) noted, “A major factor contributing to the slowness of development of a science of Behavioral Pharmacology was the late recognition that behavior is a phenomenon amenable to study by the methods of Natural Science.” The solution lies in the unequivocal demonstration of a viable laboratory approach to the scientific investigation of the behavioral actions of drugs. However, “The use of experimental animals in the analysis of behavioral effects of drugs has been hampered by a paucity of objective, quantitative methods of study” (19). Though an early study by Skinner and Heron (65) pointed the way toward such an objective analysis, it wasn’t until the late 1950’s that this promise began to be realized. The new scientific domain, behavioral pharmacology, grew principally out of an amalgamation of the concepts of an operational analysis of behavior propounded by Skinner (63, 64) and the more firmly established concepts of experimental pharmacology.
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References
Allman, L. Group drinking during stress: effect on alcohol intake and group processes. Int. J. Addict. 8: 475–488, 1973.
Allman, L. R., H. A. Taylor, and P. E. Nathan. Group drinking during stress: effects on drinking behavior, affect, and psychopathology. Am. J. Psychiat. 129: 669–678, 1972.
Altman, J. L., R. E. Meyer, S. M. Mirin and H. B. Mcnamee. Opiate antagonists and the modification of heroin self-administration behavior in man: an experimental study. American Psychiatric Association Meeting, May 1974.
Anderson, W. W., and T. Thompson. Ethanol self-administration in water-satiated rats. Pharmacol., Biochem. Behav. 2: 447–454, 1974.
Balster, R. L., and C. R. Schuster. Fixed-interval schedule of cocaine reinforcement: effect of dose and infusion duration. Exp. Anal. Behav. 20: 119–129, 1973.
Bigelow, G., and I. Liebson. Cost factors controlling alcoholic drinking. Psychol. Rec. 22: 305–314, 1972.
Bigelow, G., I. Liebson and R. Griffiths. Alcoholic drinking: suppression by a brief time-out procedure. Behav. Res. Ther. 12: 107–115, 1974.
Bigelow, G., I. Liebson and C. Lawrence. Prevention of alcohol abuse by reinforcement of incompatible behavior. Presented at the meeting of the Association for the Advancement of Behavior Therapy, Miami, December 1973.
Boudin, H. Environmental intervention with young drug offenders. Environmental Approaches to Emotional Disturbances. Columbia, Mo.: Univ. Extension Div., Univ. of Missouri, 1973, p. 19–43.
Cohen, M., I. Liebson and L. Faillace. Controlled drinking by chronic alcoholics over extended periods of free access. Psychol. Rep. 32: 1107–1110, 1973.
Cohen, M., I. A. Liebson, L. A. Faillace and R. P. Allen. Moderate drinking by chronic alcoholics: a schedule-dependent phenomenon. J. Nerv. Ment. Dis. 153: 434–444, 1971.
Cohen, M., I. A. Liebson, L. A. Faillace and W. Speers. Alcoholism: controlled drinking and incentives for abstinence. Psychol. Rep. 28: 575–580, 1971.
Crowder, W. F., S. G. Smith, W. M. Davis, J. T. Noel and W. R. Coussens. Effect of morphine dose size on the conditioned reinforcing potency of stimuli paired with morphine. Psychol. Rec. 22: 441–448, 1972.
Davis, W. M., and J. R. Nichols. A technique for self-injection of drugs in the study of reinforcement. J. Exp. Anal. Behav. 6: 233–235, 1963.
Davis, W. M., and S. G. Smith. Alpha-methyltyrosine to prevent self-administration of morphine and amphetamine. Curr. Ther. Res. 14: 814–819, 1972.
Davis, W. M., and S. G. Smith. Blocking of morphine based reinforcement by alpha-methyltyrosine. Life Sci. 12: 185–191, 1973.
Davis, W. M., and S. G. Smith. Haloperidol effects on morphine self-administration: testing for pharmacological modification of the primary reinforcement mechanism. Psychol. Rec. 23: 215–221, 1973.
Davis, W. M., and S. G. Smith. Behavioral control exerted by an amphetamine based conditioned reinforcer. In: Drug Addiction, Vol. Ill: Neurobiology, Behavior and its Influences, edited by J. M. Singh and H. Lai. New York: Intercontinental Medical Book Corp., 1974.
Dews, P. B. Differential sensitivity to pentobarbital of pecking performance in pigeons depending on the schedule of reward. J. Pharmacol. Exp. Ther. 113: 393–401, 1955.
Dews, P. B., and W. Morse. Behavioral pharmacology. Annu. Rev. Pharmacol. 1: 145, 1961.
Dougherty, J. A., and R. Pickens. Development of temporal patterns of cocaine self-administration. Proceedings, 81st Annual Convention of the American Psychological Association, Montreal, 1973, p. 1003–1004.
Dougherty, J. A., and R. Pickens. Fixed-interval schedules of intravenous cocaine presentation in rats. J. Exp. Anal. Behavior. 20: 111–118, 1973.
Dougherty, J. A., and R. Pickens. Effects of phenobarbital and SKF 525A on cocaine self-administration in rats. In Drug Addiction, Vol. III: Neurobiology, Behavior and its Influences, edited by J. M. Singh and H. Lai. New York: Intercontinental Medical Book Corp., 1974.
Falk, J. L. Production of polydipsia in normal rats by an intermittent food schedule. Science 133: 195–196, 1961.
Falk, J. L. Studies on schedule-induced polydipsia. In: Thirst, edited by M. J. Weyner. New York: Macmillan, 1964, p. 95–116.
Findley, J. D., W. W. Robinson and L. Peregrino. Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of a self-infusion preference procedure. Psychopharmacologia 26: 93–114, 1972.
Goldberg, S. R. Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey. J. Pharmacol. Exp. Ther. 186: 18–30, 1973.
Goldberg, S. R., F. Hoffmeister, U. U. Schlichting and W. Wuttke. A comparison of pentobarbital and cocaine self-administration in rhesus monkeys: effects of dose and fixed-ratio parameter. J. Pharmacol. Exp. Ther. 179: 227–283, 1971.
Gotestam, K. G. Intragastric self-administration of medazapam in rats. Psychopharmacologia 28: 87–94, 1973.
Grove, R., and C. R. Schuster. Effects of response-contingent shock and extinction on cocaine self-administration by monkeys. In press.
Gunne, L. M., E. Anggard and L. E. Jonsson. Blockade of amphetamine effects in human subjects. Presented at the International Institute on the Prevention and Treatment of Drug Dependence. Lausanne: I. C. A. A., 1970.
Hoffmeister, F., S. R. Goldberg, U. Schlichting and W. Wuttke. Self-administration of d-amphetamine, morphine and chlorpromazine by cocaine “dependent” rhesus monkeys. Naunyn-Schmiedebergs Arch. Pharmakol. 266: 359–360, 1970.
Hunt, G. M., and N. H. Azrin. Community reinforcement approach to alcoholism. Presented at the Meeting of the American Psychological Association, 1972.
Iglauer, C., and J. Woods. Concurrent performances: reinforcement by different doses of cocaine in rhesus monkeys. J. Exp. Anal. Behav. 22: 179–196, 1974.
Jarvik, M. E. Tobacco smoking in monkeys. Ann. N. Y. Acad. Sci. 142: 280, 1967.
Korman, M., I. J. Knoff and R. L. Lear. Alcohol as a discriminative stimulus: a preliminary report. Tex. Rep. Biol. Med. 20: 61–63, 1962.
Lester, D. Self-maintenance of intoxication in the rats. Q. J. Stud. Alcohol 22: 223–231, 1961.
Lierson, I. A., M. Cohen, L. A. Faillace and R. F. Ward. The token economy as a research method in alcoholism. Psychiatr. Q. 45: 574–581, 1971.
Meisch, R. A., and T. Thompson. Ethanol intake in the absence of concurrent food reinforcement. Psychopharmacologia 22: 72–79, 1971.
Meisch, R. A., and T. Thompson. Ethanol intake during schedule-induced polydipsia. Physiology and Behavior 8: 471–475, 1972.
Meisch, R. A., and T. Thompson. Ethanol reinforcement: effects of concentration during food deprivation. Finn. Found. Ale. Stud. 20: 71–75, 1972.
Meisch, R. A., and T. Thompson. Ethanol as a reinforcer: an operant analysis of ethanol dependence. In: Drug Addiction, Vol. Ill: Neurobiology and Influences on Behavior, edited by J. M. Singh and H. Lai. New York: Intercontinental Medical Book Corp., 1974.
Meisch, R. A., and T. Thompson. Ethanol as a reinforcer: effects of fixed-ratio size and food deprivation. Psychopharmacologia 28: 171–183, 1973.
Meisch, R. A., and T. Thompson. Rapid acquisition of ethanol as a reinforcer for rats. Psychopharmacologia 37: 311–321, 1974.
Meisch, R. A., J. E. Henningfield, and T. Thompson. Establishment of ethanol as a reinforcer for rhesus monkeys via the oral route: initial results. In: Advances in Experimental Medicine and Biology, Vol. 59, edited by M. M. Gross. New York: Plenum, 1975.
Mello, N. Behavioral studies of alcoholism. In: The Biology of Alcoholism, edited by B. Kissin and H. Begleitter. New York: Plenum, 1972.
Mello, N. K., and J. H. Mendelson. Operant analysis of drinking patterns of chronic alcoholics. Nature 206: 43–46, 1965.
Nichols, J. R. A procedure which produces sustained opiate-directed behavior (morphine addiction) in the rat. Psychol. Rep. 13: 895–904, 1963.
Peacock, L. J., and J. A. Watson. Radiation-induced aversion to alcohol. Science 143: 1462–1463, 1964.
Pickens, R., G. Bigelow and R. Griffiths. An experimental approach to treating chronic alcoholism: a case study and one-year follow-up. Behav. Resh. Ter. 11: 321–325, 1973.
Pickens, R., W. C. Bloom and T. Thompson. Effects of reinforcement magnitude and session length on response rate of monkeys. Proceedings, 77th Annual Convention of the American Psychological Association, 1969, p. 809–810.
Pickens, R., R. A. Meisch and J. A. Dougherty. Chemical interactions in methamphetamine reinforcement. Psychol. Rep. 23: 1267–1270, 1968.
Pickens, R., and T: Thompson. Cocaine reinforcement behavior in rats: effects of reinforcement magnitude and fixed-ratio size. J. Pharmacol. Exp. Ther. 161: 122–129, 1968.
Pickens, R., and T. Thompson. Characteristics of stimulant drug reinforcement. In: Stimulus Properties of Drugs, edited by T. Thompson and R. Pickens. New York: Appleton-Century-Crofts, 1971.
Pickens, R., and T. Thompson. Simple schedules of drug self-administration in animals. In: Drug Addiction, Vol. T. Experimental Pharmacology, edited by J. M. Singh, L. H. Miller and H. Lai. New York: Futura, 1972, p. 107–120.
Pickens, R., T. Thompson and D. Muchow. Cannabis and phencyclidine self-administration by animals. In: Psychic Dependence, edited by L. Goldberg and F. Hoffmeister. Berlin: Springer-Verlag, 1973, p. 78–86.
Pickens, R., L. Gustafson, M. Cunningham and L. Heston. Barbiturate self-administration by human sedative abusers. Rep. Res. Lab. Dept. of Psychiatry, Univ. of Minnesota, No. PR-75–1, January, 1975.
Pozuelo, J., and F. W. Kerr. Suppression of craving and other signs of dependence in morphine-addicted monkeys by administration of alpha-methyl-paratyrosine. Mayo Clin. Proc. 47: 621–628, 1972.
Schuster, C. R., and T. Thompson. Self-administration of and behavioral dependence on drugs. Annu. Rev. Pharmacol. 9: 483–502, 1969.
Schuster, C. R., and J. Woods. The conditioned reinforcing effects of stimuli associated with morphine reinforcement. Int. J. Addict. 3: 223–230, 1968.
Senter, R. J., and J. D. Sinclair. Self-maintenance of intoxication in the rat: a modified replication. Psychonomic Sci. 9: 291–292, 1967.
Sidman, M. Behavioral Pharmacology. Psychopharmacologia 1: 1–19, 1959.
Skinner, B. F. The Behavior of Organisms. New York: Appleton-Century-Crofts, 1938.
Skinner, B. F. Science and Human Behavior. New York: Macmillan, 1953.
Skinner, B. F., and W. T. Heron. Effects of caffeine and benzedrine upon conditioning and extinction. Psychol. Rec. 1: 340–346, 1937.
Spragg, S. D. S. Comparative Psychology Monographs. 15: No. 7, 1940.
Stolerman, I. P., and R. Kumar. Preferences for morphine in rats: validation of an experiment model of dependence. Psychopharmacologia 17: 137–150, 1970.
Stretch, R., G. J. Gerber and J. M. Woods. Factors affecting behavior maintained by response-contingent intravenous infusions of amphetamine in squirrel monkeys. Can. J. Physiol. Pharmacol 48: 581–589, 1971.
Thompson, T., G. Bigelow and R. Pickens. Environmental variables influencing drug self-administration. In: Stimulus Properties of Drugs, edited by T. Thompson and R. Pickens. New York: Appleton-Century-Crofts, 1971.
Thompson, T., R. Griffiths and R. Pickens. Behavioral variables influencing drug self-administration by animals: implications for controlling human drug abuse. In: Psychic Dependence, edited by L. Goldberg and F. Hoffmeister. Berlin: Springer-Verlag, 1973, p. 88–103.
Thompson, T., and W. Ostlund. Susceptibility to re-addiction as a function of the addiction and withdrawal environment. J. Comp. Physiol. Psychol. 59: 388–392, 1965.
Thompson, T., and R. Pickens. Drug self-administration and conditioning. In: Scientific Basis of Drug Dependence, edited by H. Steinberg. London: Churchill, 1969.
Thompson, T., and R. Pickens. Drugs as reinforcers: schedule considerations. In: Schedule Effects: Drugs, Drinking and Aggression, edited by R. Gilbert and J. D. Keehn, Toronto: Univ. of Toronto Press, 1972.
Thompson, T., and C. R. Schuster. Morphine self-administration, food-reinforced and avoidance behaviors in rhesus monkeys. Psychopharmacologia 5: 87–94, 1964.
Thompson, T., and C. R. Schuster. Behavioral Pharmacology. New Jersey: Prentice Hall, 1968.
Weeks, J. Experimental morphine addiction: method for automatic intravenous injection in unrestrained rats. Science 138: 143–144, 1962.
Wilson, M., and C. R. Schuster. Pharmacological modification of the self-adrninistration of cocaine and SPA in the rhesus monkey. NAS-NRC Committee on Problems of Drug Dependence, Indianapolis, Indiana, 1968.
Winger, G., and J. H. Woods. The reinforcing property of ethanol in the rhesus monkey: I. Initiation, maintenance and termination of intravenous ethanol-reinforced responding. Ann. N. V. Acad. Sci. 215: 162–175, 1973.
Woods, J. H., D. A. Downs and J. M. Carney. Behavioral functions of narcotic antagonists: response-drug contingencies. Federation Proc. 34: 1777–1784, 1975.
Woods, J. H., and C. R. Schuster. Reinforcement properties of morphine, cocaine, and SPA as a function of unit dose. Int. f. Addict. 3: 231–237, 1968.
Yanagita, T., S. Takahashi, K. Ishida and H. Finamoto. Voluntary inhalation of volatile anesthetics and organic solvents by monkeys, Japan. J. Clin. Pharmacol. 1: 13–16, 1970.
Yokel, R. A., and R. Pickens. Self-administration of optical isomers of amphetamine and methylamphetamine by rats. J. Pharmacol. Exp. Ther. 187: 27–33, 1973.
Yokel, R. A., and R. Pickens. Drug level of d-and J-amphetamine during intravenous self-administration. Psychopharmacologia 34: 255–264, 1974.
Yokel, R. A., and R. Pickens. Extinction following amphetamine and methyl-amphetamine self-administration by rats. In press.
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Thompson, T., Pickens, R. (1975). An experimental analysis of behavioral factors in drug dependence. In: Weiss, B., Laties, V.G. (eds) Behavioral Pharmacology. FASEB Monographs, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2634-2_3
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