Amphetamine toxicity: behavioral and neuropathological indexes

  • Charles R. Schuster
  • Marian W. Fischman
Part of the FASEB Monographs book series (FASEBM, volume 4)


Toxicology, a science that “deals with poisons and their effects” (43), has traditionally emphasized the identification and analysis of chemicals that interfere with life processes. As techniques became more sophisticated, evaluation of morphological lesions came within the province of toxicologists. Only recently, however, has the possibility of correlating function and morphology been suggested to the student in toxicology (e.g., 42); he has been instructed to critically evaluate chemically induced physiological, biochemical and morphological changes. The indexes of toxicity have usually been alterations in blood and urine chemistry, body temperature, and the like. Many of these physiological changes may be the effect of irreversible morphological pathology, and therefore, in fact, indicative of life-threatening toxicity. These irreversible changes represent an end point in the development of overt indications of toxicity. It is of the utmost importance to be able to detect less obvious, but still destructive damage. What is needed are a series of sensitive measures that might, together or separately, indicate the presence of a potentially poisonous substance.


Rhesus Monkey Lever Press Chronic Amphetamine Amphetamine Abuse Chronic Regimen 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Charles R. Schuster
    • 1
    • 2
  • Marian W. Fischman
    • 1
    • 2
  1. 1.Department of PsychiatryUniversity of Chicago Pritzker School of MedicineChicagoUSA
  2. 2.Department of Pharmacological and Physiological SciencesUniversity of Chicago Pritzker School of MedicineChicagoUSA

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