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Effects of aging on the differentiation and proliferation potentials of cells of the immune system

  • T. Makinodan
  • W. H. Adler
Part of the Faseb Monographs book series (FASEBM, volume 3)

Abstract

An attempt has been made here to show that the immune system can begin to decline in function shortly after an individual reaches maturity. The decline is due in part to changes in the environment of the cells but primarily to changes in the precursor cells of the system. This is reflected in their inability to proliferate and possibly differentiate efficiently. These findings show that the immune system can serve as an excellent model to study how aging can perturb the process of cells undergoing proliferation and differentiation.—Makinodan, T. and W. H. Adler. Effects of aging on the differentiation and proliferation potentials of cells of the immune system. Federation Proc. 34: 153–158, 1975.

Keywords

Spleen Cell Young Mouse Sheep Erythrocyte Spleen Weight Christmas Tree 
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Copyright information

© Federation of American Societies 1975

Authors and Affiliations

  • T. Makinodan
    • 1
    • 2
  • W. H. Adler
    • 1
    • 2
  1. 1.Laboratory of Cellular and Comparative Physiology Gerontology Research CenterNational Institutes of HealthBaltimoreUSA
  2. 2.Human DevelopmentNational Institutes of Health Bethesda, and the Baltimore City HospitalsBaltimoreUSA

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