Abstract
Neonatal liver or adult spleen was used as a source of B-lymphocytes in reconstituting lethally irradiated, syngeneic mice. Recipients were all given excess adult, syngeneic thymus cells and were immunized with dinitrophenylated bovine gamma globulin. The distribution of avidities of plaque-forming cells produced by immunized recipients of neonatal liver was highly restricted in comparison with animals reconstituted with adult spleen indicating a restriction of B-lymphocyte heterogeneity in the neonatal mouse.—Siskind, G. W. and E. A. Goidl. Ontogeny of B-lymphocyte function with respect to the heterogeneity of antibody affinity. Federation Proc. 34: 151–152, 1975.
From Session V, Development and Aging in Organ Systems, of the FASEB Conference on Biology of Development and Aging, presented at the 58th Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, N.J., April 11, 1974.
Supported in part by research grant AM-13701 from the Public Health Service.
Career Scientist of the Health Research Council of the City of New York under Investigatorship I-593.
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Siskind, G.W., Goidl, E.A. (1975). Ontogeny of B-lymphocyte function with respect to the heterogeneity of antibody affinity. In: Thorbecke, G.J. (eds) Biology of Aging and Development. Faseb Monographs, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2631-1_28
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