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Differentiation of thymus cells

  • Irving L. Weissman
  • Myra Small
  • C. Garrison Fathman
  • Leonard A. Herzenberg
Part of the Faseb Monographs book series (FASEBM, volume 3)

Abstract

The process of cellular differentiation in the thymus presumably leads to the development of immunocompetent peripheral “T” lymphocytes (1, 6). Although there are considerable data showing the existence of a small pool of immunocompetent cortisone-resistant, medullary thymocytes which, as a population, bear low concentration of Thy 1.2, lack TL antigens, and exhibit high concentrations of H-2, the identification of their immediate precursors is not yet known (1). Under conditions of parenteral hydrocortisone administration it has been demonstrated that at least some of the cortisone-resistant medullary thymocytes are derived from an intrathymic pool of cortisone-sensitive cortical precursors (7). In this paper we demonstrate the in vivo maturation of at least three lines of “mature” thymus cells from a precursor subclass using selective labeling of these precursors in situ as a marker.

Keywords

Label Index Thymus Cell Thymic Lymphocyte Hydrocortisone Acetate Bright Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Federation of American Societies 1975

Authors and Affiliations

  • Irving L. Weissman
    • 1
    • 2
  • Myra Small
    • 1
    • 3
  • C. Garrison Fathman
    • 1
  • Leonard A. Herzenberg
    • 1
  1. 1.Laboratory of Experimental Oncology, Department of Pathology and Department of GeneticsStanford University School of MedicineStanfordUSA
  2. 2.Salk InstituteSan DiegoUSA
  3. 3.Department of Cell BiologyWeizmann Institute for ScienceRehovothIsrael

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