Age-related changes in thermoregulatory capacity of tryptophan-deficient rats

  • Paul E. Segall
  • Paola S. Timiras
Part of the Faseb Monographs book series (FASEBM, volume 3)


From a larger study seeking to develop indexes of physiological aging, the present experiment was designed 1) to test thermoregulatory capacity in the aging and old rat subjected to 3 minutes of whole-body ice water immersion, and 2) using this index of physiological age, to determine whether tryptophan deficiency from time of weaning can retard the onset of senescence. Results indicate a progressive prolongation of temperature recovery time from young to middle age to old, and tryptophan-deficient animals restored to commercial diet at middle age show the thermoregulatory capacity of young adults. The implications of tryptophan deficiency with respect to brain development, serotonin metabolism, and temperature regulation are also discussed in terms of the possibility of intervening with the aging process.—Segall, P. E. and P. S. Tlmiras. Age-related changes in thermoregulatory capacity of tryptophan-deficient rats. Federation Proc. 34: 83–85, 1975.


Commercial Diet Physiological Aging Average Body Temperature Serotonin Metabolism Torula Yeast 
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  1. 1.
    Berg, B. N. Nutrition and longevity in the rat. I. Food intake in relation to size, health and fertility J. Nutr. 71: 242, 1960.PubMedGoogle Scholar
  2. 2.
    Berg, B. N., and H. S. Simms. Nutrition and longevity in the rat. II. Longevity and onset of disease with different levels of food intake./. Nutr 71: 255, 1960.Google Scholar
  3. 3.
    Fernstrom, J. D., and R. J. Wurtman. Effect of chronic corn consumption on serotonin content of rat brain. Nature New Biol. 234: 62, 1971.PubMedGoogle Scholar
  4. 4.
    Finch, C. E. Enzyme activities, gene function and ageing in mammals (review). Exptl Gerontol 7: 53, 1972.CrossRefGoogle Scholar
  5. 5.
    Finch, C. E. Catecholamine metabolism in the brains of ageing male mice. Brain Res. 52: 261, 1973.PubMedCrossRefGoogle Scholar
  6. 6.
    Gordon, R. S. Growth arrest through tryptophan deficiency in the very young chicken. Sixth International Congress of Nutrition, Edinburgh, Scotland, Abstract 471, 1963.Google Scholar
  7. 7.
    McCay, C. M. Chemical aspects of ageing and the effect of diet upon ageing. In: Cowdry’s Problems of Ageing, 3rd edition, edited by A. I. Lansing. Baltimore: Williams 8c Wilkins, 1952, p. 139.Google Scholar
  8. 8.
    McCay, C. M., L. A. Maynard, G. Sperlingand L. L. Barnes. Retarded growth, life span, ultimate body size and age changes in the albino rat after feeding diets restricted in calories. J. Nutr. 18: 1, 1939.Google Scholar
  9. 9.
    McCay, C. M., G. Sperling and L. L. Barnes. Growth, ageing, chronic diseases and life span in rats. Arch. Biochem. 2: 469, 1943.Google Scholar
  10. 10.
    McRoberts, M. R. Growth retardation of day old chickens and physiological effects at maturity. J. Nutr. 87: 31, 1965.PubMedGoogle Scholar
  11. 11.
    Myers, R. D., and T. L. Yaksh. The role of hypothalamic monoamines in hibernation and hypothermia. In: Hibernation and Hypothermia, Perspectives and Challenges, edited by F. E. South, et al. New York: American Elsevier, 1972, p. 551.Google Scholar
  12. 12.
    Ross, M. H. Length of life and nutrition Paul E. Segall and Paola S. Timiras in the rat. J. Nutr. 75: 197, 1961.PubMedGoogle Scholar

Copyright information

© Federation of American Societies 1975

Authors and Affiliations

  • Paul E. Segall
    • 1
  • Paola S. Timiras
    • 1
  1. 1.Department of Physiology-AnatomyUniversity of CaliforniaBerkeleyUSA

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