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Unlimited division potential of precancerous mouse mammary cells after spontaneous or carcinogen-induced transformation

  • C. W. Daniel
  • B. D. Aidells
  • D. Medina
  • L. J. FaulkinJr.
Part of the Faseb Monographs book series (FASEBM, volume 3)

Abstract

Serial transplantation of normal mouse mammary gland in young, isogenic hosts results in progressive loss of division potential, and the transplant line is eventually lost. This is interpreted as an expression of senescence at the cell and tissue level, and it inevitably occurs even though experimental conditions for growth are judged to be optimal. An indefinite extension of mammary growth span can be accomplished by transformation of these normal cells into precancerous cell types, which grow as a benign tissue but which may, however, occasionally undergo a second transformation into a malignant carcinoma. All precancerous tissues tested displayed unlimited growth potential, regardless of whether they occurred spontaneously, or were induced by oncogenic viruses or by administration of chemical carcinogens. Precancerous tissues of both ductal and lobuloalveolar morphology grew continuously. These results indicate that release from cell aging, as measured by the acquisition of unlimited growth potential, is associated with the precancerous state per se, and occurs as an early event in the transition from normal to malignant mammary cells.—Daniel, C. W., B. D. Aidells, D. Medina and L. J. Faulkin, Jr. Unlimited division potential of precancerous mouse mammary cells after spontaneous or carcinogen-induced transformation. Federation Proc. 34: 64–67, 1975.

Keywords

Mouse Mammary Tumor Virus Serial Transplantation Normal Mammary Tissue Primary Implant Trans Plant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviation

MTV

mouse mammary tumor virus

NIV

nodule inducing virus

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References

  1. 1.
    Aidells, B. D., and C. W. Daniel. J. Natl. Cancer Inst. 52: 1855, 1974.PubMedGoogle Scholar
  2. 2.
    Daniel, C. W. Advan. Gerontol. Res. 4: 167, 1972.Google Scholar
  3. 3.
    Daniel, C. W., K. B. Deome. L. J. T. Young, P. B. Blair and L. J. Faulkin, JR. Proc. Natl. Acad. Sci. U.S. 61: 53, 1968.CrossRefGoogle Scholar
  4. 4.
    Daniel, C. W., and L. J. T. Young. Exptl. Cell Res. 65: 27, 1971.PubMedCrossRefGoogle Scholar
  5. 5.
    Deome, K. B., L. J. Faulkin, JR, H. A. Bern and P. B. Blair. Cancer Res. 19: 515, 1959.PubMedGoogle Scholar
  6. 6.
    Faulkin, L. J., JR. J. Natl. Cancer Inst. 36: 289, 1966.PubMedGoogle Scholar
  7. 7.
    Faulkin, L. J., JR., and K. B. Deome. J. Natl. Cancer Inst. 24: 953, 1960.PubMedGoogle Scholar
  8. 8.
    Harrison, D. E. Proc. Natl. Acad Sci U.S. 70: 3184, 1973.CrossRefGoogle Scholar
  9. 9.
    Hayflick, L. Exptl. Cell Res. 37: 614, 1965.PubMedCrossRefGoogle Scholar
  10. 10.
    Krohn, P. L. Proc. Roy. Soc. London Ser. B. 157: 128, 1962.CrossRefGoogle Scholar
  11. 11.
    Krohn, P. L. In: Topics of the Biology of Aging, edited by P. L. Krohn. New York: Wiley, 1966, p. 125.Google Scholar
  12. 12.
    Loeb, J., and M. M. Kirtz. Am. J. Cancer 36: 56, 1939.Google Scholar
  13. 13.
    Medina, D., and K. B. Deome. J. Natl. Cancer Inst. 40: 1303, 1968.PubMedGoogle Scholar
  14. 14.
    Medina, D., and K. B. Deome. J. Natl. Cancer Inst. 45: 353, 1970.PubMedGoogle Scholar
  15. 15.
    Medina, D., K. B. Deome, and D. R. Pitelka. J. Natl. Cancer Inst. 46: 1153, 1971.PubMedGoogle Scholar
  16. 16.
    Nandi, S., and C. M. Mcgrath. Advan. Cancer Res. 17: 353, 1973.CrossRefGoogle Scholar
  17. 17.
    Till, J. E., and E. A. Mcculloch. Radiation Res. 14: 213, 1961.PubMedCrossRefGoogle Scholar
  18. 18.
    Till, J. E., E. A. Mcculloch and L. Siminovitch. J. Natl. Cancer Inst. 33: 707, 1964.PubMedGoogle Scholar

Copyright information

© Federation of American Societies 1975

Authors and Affiliations

  • C. W. Daniel
    • 1
  • B. D. Aidells
    • 1
  • D. Medina
    • 1
    • 2
  • L. J. FaulkinJr.
    • 1
    • 3
  1. 1.Division of Natural SciencesUniversity of CaliforniaSanta CruzUSA
  2. 2.Department of AnatomyBaylor College of MedicineHoustonUSA
  3. 3.Department of AnatomyUniversity of CaliforniaDavisUSA

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