Human Growth pp 183-213 | Cite as

Prepubertal and Pubertal Endocrinology

  • Jeremy S. D. Winter


Growth is intrinsically linked with both an increment in cell mass and an acceleration of cellular proliferation. Growing mammalian cells have in common a characteristic set of biochemical phenomena, including an increase in protein synthesis, increased incorporation of nucleic acid precursors into RNA and DNA, and poly-some aggregation (Hershko et al.,1971). These growth-mediating processes are limited by the availability of various nutrients, metabolites, and ions in the extracellular environment, but are also susceptible to regulation by a variety of agents, including hormones. Control points for this hormonal influence upon growth include: membrane-associated processes involved with the transport of amino acids, energy substrates, and ions; transcriptional processes involved in the expression of genetic information through the synthesis of new RNA; and translational processes as reflected in the numbers and efficiency of ribosomal protein-synthesizing units.


Growth Hormone Thyroid Hormone Luteinizing Hormone Human Growth Hormone Precocious Puberty 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Jeremy S. D. Winter
    • 1
  1. 1.Endocrine-Metabolism Section, Health Sciences CenterUniversity of ManitobaWinnipegCanada

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