l-Asparaginase as a Model for Enzyme Therapy of Substrate-Dependent Tumors

  • E. D. Siu Chong
  • T. M. S. Chang


A great deal of work is being carried out using l-asparaginase as a model system for the “selective nutritional deprivation” approach to cancer therapy. Certain tumor cells, unlike normal cells, cannot synthesize enough asparagine and depend on extracellular supplies for asparagine. Selective depletion of this extracellular source of asparagine by l-asparaginase can lead to the suppression of asparagine-dependent tumors.


Acute Lymphocytic Leukemia Asparagine Synthetase Enzyme Therapy Bacillus Coagulans Asparaginase Activity 


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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • E. D. Siu Chong
    • 1
  • T. M. S. Chang
    • 2
  1. 1.Department of PhysiologyMcGill UniversityMontrealCanada
  2. 2.Departments of Physiology and MedicineMcGill UniversityMontrealCanada

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