Erythrocytes, especially human erythrocytes, have been very extensively studied because of their medical interest and because they are conveniently obtained for biochemical and physiological studies. Mammalian erythrocytes lack nuclei which are pinched off from the cells when they pass through narrow orifices while escaping from the bone marrow. Once matured, they lack ribosomes and have lost the capability of protein synthesis. Because of their inability to renew themselves, the lifetime of normal human erythrocytes is restricted to about 120 days. Cell energy metabolism is restricted to glycolysis since the cells do not contain mitochondria. Their basic function is to serve as a container for hemoglobin. In this article we discuss a procedure for utilizing erythrocytes as containers for foreign proteins and enzymes as well as hemoglobin.
KeywordsUric Acid Survival Characteristic Lysosomal Storage Disease Erythrocyte Ghost Hypotonic Medium
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