The Mode of Action of Progestagens on Endometrial Carcinoma

  • Jerry R. Reel
Part of the Current Topics in Molecular Endocrinology book series (CTME, volume 4)


Buoyed by the beneficial effects of endocrine therapy in prostate and breast cancer, Kelley and Baker (1) in 1951 began treating patients with metastatic or recurrent endometrial carcinoma with progestational compounds. By the late 1950’s and early 1960’s several other clinicians also were using progestagens to treat selected cases of endometrial carcinoma (2–9). From the data that have accumulated, it appears that remission* of the disease occurs in about 30–35% of the treated patients (1,10,11), a success rate comparable to that achieved in treating breast cancer patients with either ablative or additive forms of endocrine therapy (12).


Progesterone Receptor Endometrial Cancer Endometrial Carcinoma Human Endometrium Nucleic Acid Synthesis 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Jerry R. Reel
    • 1
  1. 1.Department of PharmacologyParke, Davis & CompanyAnn ArborUSA

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