Mammalian Progesterone Receptors: Biosynthesis, Structure and Nuclear Binding

  • L. E. Faber
  • J. Saffran
  • T. J. Chen
  • W. W. Leavitt
Part of the Current Topics in Molecular Endocrinology book series (CTME, volume 4)


Because estrogen and progesterone receptors may be involved in the endocrine sensitivity of certain breast and endometrial carcinomas (1,2), considerable interest has been generated in the study of steroid receptors in hormonally sensitive tumors. In this chapter, we will review some recent progress on three aspects of receptor biology as applied to mammalian progesterone receptors: regulation of receptor biosynthesis, structure of the receptor and nuclear binding of the steroid-receptor complex.


Progesterone Receptor Sedimentation Coefficient Nuclear Binding Sucrose Density Gradient Centrifugation Nuclear Uptake 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • L. E. Faber
    • 1
  • J. Saffran
    • 1
  • T. J. Chen
    • 2
  • W. W. Leavitt
    • 2
  1. 1.Endocrine Research UnitMedical College of OhioToledoUSA
  2. 2.Department of PhysiologyUniversity of Cincinnati College of MedicineCincinnatiUSA

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