The Metabolism of Steroid Hormones in Breast Cancer: A Reappraisal

  • S. C. Brooks
Part of the Current Topics in Molecular Endocrinology book series (CTME, volume 4)


MacMahon (1), Lemon (2) and Smith and Smith (3) have emphasized that abnormal ovarian function or steroid metabolism not modified by pregnancy in early life, may well be implicated in human breast cancer etiology. Wynder (4) and Dao (5) have pointed toward an etiological role for estrogen metabolism and nutritionally-conditioned alteration of estrogen metabolism in breast cancer, as also have Stocks (6) and Hems (7). The study of steroid excretion patterns in women with breast cancer (or prior to the onset of the disease) is further recommended by Bulbrook’s observations in the women of Guernsey (8). Furthermore, there is some evidence (9) that at least part of the genetic predisposition of certain mouse strains is the result of genetically-determined ovarian function. These are but a few of the reports, published in the past decade, that pertain to steroid hormone metabolism in mammary cancer. However, before reappraising the data in this field it may be helpful to summarize what is now known of the fate of steroid hormones in the mammal.


Breast Cancer Breast Cancer Patient Estrogen Metabolism Female Breast Cancer Patient Plasma Estrogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • S. C. Brooks
    • 1
  1. 1.Department of Biochemistry, School of MedicineWayne State UniversityDetroitUSA

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