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Selecting Endocrine Therapy in Breast Cancer

  • W. L. McGuire
  • K. B. Horwitz
  • M. De La Garza
Part of the Current Topics in Molecular Endocrinology book series (CTME, volume 4)

Abstract

In estrogen target tissues and hormone-dependent tumors, the steroid enters the cells and binds to a cytoplasmic protein called the estrogen receptor (ER). The steroid-receptor complex then migrates to the nuclei, where it initiates the biochemical events characteristic of estrogen stimulation. Since ER is absent in tissues not responsive to estrogen, studies have been designed to show whether ER in human breast cancer might be used to identify those patients likely to respond to endocrine therapy.

Keywords

Estrogen Receptor Endocrine Therapy Human Breast Tumor Positive Tumor Estrogen Receptor Hormone Dependence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • W. L. McGuire
    • 1
  • K. B. Horwitz
    • 1
  • M. De La Garza
    • 1
  1. 1.Health Science CenterUniversity of Texas SanAntonioUSA

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