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The Relevance of Studies on Androgen Action to Prostatic Cancer

  • W. Ian P. Mainwaring
Part of the Current Topics in Molecular Endocrinology book series (CTME, volume 4)

Abstract

The classical studies of Huggins and Hodges (1) in which they reported the palliation of metastasing prostatic carcinoma by estrogens heralded a new era in the hormonal management of neoplastic disorders. This innovative work led directly to advances in the treatment of breast cancer and, to a lesser extent, in the arrest of malignant diseases of the adrenal and thyroid. Of similar importance in the historical context was the later work of Jensen and Jacobsen (2) on the specificity of the uptake and retention of tritiated estradiol-173 in rat uterus which, together with the advent of radioactive precursors for macromolecular syntheses, initiated a more penetrating and enterprising investigation of the mechanism of action of steroid hormones. Striking progress has been made in describing the selective binding processes or receptor systems for steroids and the mechanisms through which hormonal regulation may be expressed at a molecular level (3). It is propitious to appraise critically the impact and relevance of these experimental studies on the clinical management of prostatic carcinoma, particularly in the present economic climate where resources and finances are at a premium.

Keywords

Prostatic Cancer Androgen Receptor Benign Prostatic Hyperplasia Prostatic Carcinoma Prostate Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • W. Ian P. Mainwaring
    • 1
  1. 1.Androgen Physiology DepartmentImperial Cancer Research Fund Lincoln’s Inn FieldsLondonUK

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