Skip to main content
SpringerLink
Log in

The Relevance of Studies on Androgen Action to Prostatic Cancer

  • Chapter
Steroid Hormone Action and Cancer

Part of the book series: Current Topics in Molecular Endocrinology ((CTME,volume 4))

Abstract

The classical studies of Huggins and Hodges (1) in which they reported the palliation of metastasing prostatic carcinoma by estrogens heralded a new era in the hormonal management of neoplastic disorders. This innovative work led directly to advances in the treatment of breast cancer and, to a lesser extent, in the arrest of malignant diseases of the adrenal and thyroid. Of similar importance in the historical context was the later work of Jensen and Jacobsen (2) on the specificity of the uptake and retention of tritiated estradiol-173 in rat uterus which, together with the advent of radioactive precursors for macromolecular syntheses, initiated a more penetrating and enterprising investigation of the mechanism of action of steroid hormones. Striking progress has been made in describing the selective binding processes or receptor systems for steroids and the mechanisms through which hormonal regulation may be expressed at a molecular level (3). It is propitious to appraise critically the impact and relevance of these experimental studies on the clinical management of prostatic carcinoma, particularly in the present economic climate where resources and finances are at a premium.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Huggins, C. and C.V. Hodges, Cancer Res. 1:293, 1941.

    CAS  Google Scholar 

  2. Jensen, E.V. and H.I. Jacobsen, Recent Progr. Hormone Res. 18:387, 1962.

    CAS  Google Scholar 

  3. King, R.J.B. and W.I.P. Mainwaring, Steroid-Cell Interactions, Butterworths, London, 1974.

    Google Scholar 

  4. Harns, G.W. and B.T. Donovan, The Pituitary Gland, Butter-worths, London, 1966.

    Google Scholar 

  5. Medical Research Council Subcommittee Findings, Br. Med. J. 2:355, 1967.

    Article  Google Scholar 

  6. Veterans Administration Cooperative Urological Research Group, Surg. Gynec. Obstet. 124:1011, 1967.

    Google Scholar 

  7. Byar, D.P., Cancer 32:1126, 1972.

    Article  Google Scholar 

  8. Blackhard, CE., R.P. Doe and G.T. Mellinger, Cancer 26:249, 1970.

    Article  Google Scholar 

  9. Blackhard, C.E. and G.T. Mellinger, Postgrad. Med., March Issue, 1972, p.140.

    Google Scholar 

  10. Editorial, Br. Med. J. 8:520, 1974.

    Google Scholar 

  11. Editorial, N.Z. Med. J. 14:113, 1974.

    Google Scholar 

  12. Robinson, M.R.G. and B.S. Thomas, Br. Med. J. 2:355, 1971.

    Article  Google Scholar 

  13. Robinson, M.R.G., R.J. Shearer and J.D. Ferguson, Br. J. Urol. 46:555, 1974.

    Article  CAS  PubMed  Google Scholar 

  14. Moore, R.A., J. Urol. 33:24, 1935.

    Google Scholar 

  15. Chiu, CL. and D.L. Weber, J. Amer. Med. Assoc. 230:724, 1975.

    Article  Google Scholar 

  16. Ashley, D.J.B., J. Pathol. Bacteriol. 90:217, 1965.

    Article  CAS  PubMed  Google Scholar 

  17. Doll, R., R. Payne and J. Waterhouse, Cancer Incidence in Five Continents, Springer-Verlag, Berlin, 1966.

    Google Scholar 

  18. Lytton, B., J.M. Emery and B.M. Harvard, J. Urol. 99:639, 1968.

    CAS  PubMed  Google Scholar 

  19. Hospital Inpatient Enquiry 1970, London, Her Majesty’s Stationary Office, 1972.

    Google Scholar 

  20. Argyrose, S., J.P. Blandy, J.G. Gow, M. Singh, G.C. Tressider and J. Vinnicombe, Br. Med. J. 3:511, 1974.

    Article  Google Scholar 

  21. Elton, J. and B.M. Wright, Br. Med. J. 3:808, 1974.

    Article  CAS  PubMed  Google Scholar 

  22. Geller, J., A. Angrist, K. Nakao and H. Newman, J. Amer. Med. Assoc. 210:1421, 1969.

    Article  CAS  Google Scholar 

  23. Scott, W.W. and J.C. Wade, J. Urol. 101:81, 1969.

    CAS  PubMed  Google Scholar 

  24. Hald, T. and A. From, Scand. J. Urol. Nephrol. 6:157, 1972.

    Article  PubMed  Google Scholar 

  25. Tveter, K.J., Acta Path. Microbiol. Scand. Sect. A., Suppl. 248:167, 1974.

    Google Scholar 

  26. Cowdrey’s Problems of Aging, A.I. Lansing (ed.), Third Edition, Springfield, C.C. Thomas & Co., 1952.

    Google Scholar 

  27. Raven, R.W., Cancer, Butterworths, London, 1957.

    Google Scholar 

  28. Kobayashi, T., J. Lobotsky and C.W. Lloyd, J. Clin. Endocrinol. Metab. 26:610, 1966.

    Article  CAS  PubMed  Google Scholar 

  29. Okamoto, M., C. Setaishi, Y. Horinch, K. Mashimo, K. Moriya and S. Ito, J. Clin. Endocrinol. Metab. 32:673, 1971.

    Article  CAS  PubMed  Google Scholar 

  30. Gomez, E.C. and S.L. Hsia, Biochemistry 7:24, 1968.

    Article  CAS  PubMed  Google Scholar 

  31. Eppenburger, U. and S.L. Hsia, J. Biol. Chem. 247:5463, 1973.

    Google Scholar 

  32. Adachi, K. and M. Kano, Steroids 20:567, 1972.

    Article  Google Scholar 

  33. Mulay, S., R. Finkelberg, L. Pinsky and S.J. Solomon, J. Clin. Endocrinol. Metab. 34:133, 1972.

    Article  CAS  PubMed  Google Scholar 

  34. Keenan, B.S., W.J. Meyer, A.J. Hadjian and C.J. Migeon, Steroids 25:535, 1975.

    Article  CAS  PubMed  Google Scholar 

  35. Lowsley, O.M., Am. J. Surg. 8:526, 1930.

    Article  Google Scholar 

  36. Fraaks, L.M., J. Pathol. Bact. 68:603, 1954.

    Article  Google Scholar 

  37. McNeal, J. E., In: Pierrepoint, C.G. and K. Griffiths (eds.), Some Aspects of the Aetiology and Biochemistry of Prostatic Cancer, Alpha Press, Cardiff, 1970, p. 23.

    Google Scholar 

  38. Tannenbaum, M., Urology 4: 758, 1974.

    Article  CAS  PubMed  Google Scholar 

  39. Armenian, H.K., A.M. Lilienfield, E.L. Diamond and I.D.J. Bross, Lancet 2:115, 1974.

    Article  CAS  PubMed  Google Scholar 

  40. Williams, R.D. and CE. Blackhard, Lancet 2:1265, 1974.

    Article  CAS  PubMed  Google Scholar 

  41. Greenwald, P., V. Kirmss, A.K. Polan and V.S. Dick, J. Nat. Cancer Inst. 53:335, 1974.

    CAS  PubMed  Google Scholar 

  42. Fraley, E.E., S. Ecker and M.M. Vincent, Science 170:340, 1970.

    Article  Google Scholar 

  43. Sinha, A.A. and C.E. Blackhard, Urology 2:114, 1973.

    Article  CAS  PubMed  Google Scholar 

  44. Sommers, S.C., Cancer 10:345, 1957.

    Article  CAS  PubMed  Google Scholar 

  45. Marmorston, J., L.J. Lombardo, S.M. Myers, H. Gierson, H. Stern and CE. Hopkins, J. Urol. 93:276, 1965.

    CAS  PubMed  Google Scholar 

  46. Frei, J.V., J. Nat. Cancer Inst. 54:524, 1975.

    CAS  PubMed  Google Scholar 

  47. Thiessen, E.U., Cancer 34:1102, 1974.

    Article  CAS  PubMed  Google Scholar 

  48. Westphal, U., Steroid-Protein Interactions, Springer-Verlag, Berlin, 1971.

    Book  Google Scholar 

  49. Pincus, C., In: Engels, E.T. and C Pincus (eds.), Hormones and the Aging Process, Academic Press, -New York, 1956, p. 1.

    Google Scholar 

  50. Kent, J.R. and A. B. Acone, In: Vermeulen, A. and D. Exley (eds.), Androgens in Normal and Pathological Conditions, Excerpta Medica, Amsterdam, 1966, p. 31.

    Google Scholar 

  51. Daughaday, W.H., J. Clin. Invest. 37:511, 1958.

    Article  CAS  PubMed  Google Scholar 

  52. Murphy, B.E.P., Canad. J. Biochem. 46:299, 1968.

    Article  CAS  Google Scholar 

  53. Steeno, O., W. Heyns, H. Van Baelen and P. de Moor, Ann. En-docr. 29:141, 1968.

    Google Scholar 

  54. Dray, F., I. Mowszowicz, M.J. Ledru, O. Crépy, C Delzant and J. Sebaoun, Ann. Endocr. 30:223, 1969.

    PubMed  Google Scholar 

  55. de Moor, P., O. Steeno, W. Heyns and H. Van Baelen, Ann. Endocr. 30:233, 1969.

    PubMed  Google Scholar 

  56. Vermeulen, A., T. Stoica and L. Verdonck, J. Clin. Endocrinol. Metab. 33:759, 1971.

    Article  CAS  PubMed  Google Scholar 

  57. Ofner, P., Vit. Horm. 26:237, 1969.

    Article  Google Scholar 

  58. Siiteri, P.K. and J.D. Wilson, J. Clin. Invest. 49:1737, 1970.

    Article  CAS  PubMed  Google Scholar 

  59. Mostofi, F.K., In: Campbell, M.F. and K.J. Harrison (eds.), Urology, W.B. Saunders & Co., Philadelphia, 1970, p. 1075.

    Google Scholar 

  60. Farnsworth, W.E., Invest. Urol. 8:367, 1971.

    CAS  PubMed  Google Scholar 

  61. Gross, S.R., L. Aronow and W.B. Pratt, Biochem. Biophys. Res. Comm. 32:66, 1968.

    Article  CAS  PubMed  Google Scholar 

  62. Gross, S.R., L. Aronow and W.B. Pratt, J. Cell. Biol. 44: 103, 1970.

    Article  CAS  PubMed  Google Scholar 

  63. Wira, C. and Munck, A., J. Steroid Biochem. 5:810, 1974.

    Google Scholar 

  64. Williams, D. and J. Gorski, Biochem. Biophys. Res. Comm. 45: 258, 1971.

    Article  CAS  PubMed  Google Scholar 

  65. Milgrom, E., M. Atger and E.-E. Baulieu, Adv. Biosci. 7 : 235, 1971.

    Google Scholar 

  66. Giorgi, E.P., J.C. Stewart, J.K. Grant and I.M. Shirley, Biochem. J. 126:107, 1972.

    CAS  PubMed  Google Scholar 

  67. Giorgi, E.P., I.M. Shirley, J.K. Grant and J.C. Stewart, Biochem. J. 132:465, 1973.

    CAS  PubMed  Google Scholar 

  68. Giorgi, E.P., J.C. Stewart, J.K. Grant and R. Scott, Biochem. J. 123:41, 1971.

    CAS  PubMed  Google Scholar 

  69. Harrison, R.W., S. Fairfield and D.N. Orth, Biochemistry 14: 1304, 1975.

    Article  CAS  PubMed  Google Scholar 

  70. Zuckerman, S. and J.R. Groome, J. Pathol. Bact. 44:113, 1937.

    Article  Google Scholar 

  71. McNeal, J.E., Workshop on Benign Prostatic Hypertrophy, N.I.H., In Press.

    Google Scholar 

  72. Harper, M.E., C.G. Pierrepoint, A.R. Fahmy and K. Griffiths, J. Endocrinol. 49:213, 1971.

    Article  CAS  PubMed  Google Scholar 

  73. Evans, C.R. and G.C Pierrepoint, J. Endocrinol. 64:539, 1975.

    Article  CAS  PubMed  Google Scholar 

  74. Dunning, W.F., M.R. Curtis and A. Segaloff, Cancer Res. 6: 256, 1946.

    CAS  PubMed  Google Scholar 

  75. Mirand, E.A. and W.J. Staubitz, Proc. Soc. Exp. Biol. Med. 93:451, 1956.

    Google Scholar 

  76. Aughey, E., R. Scott and I. McLaughlin, Br. J. Urol. 46: 561, 1974.

    Article  CAS  PubMed  Google Scholar 

  77. Brendler, H., Nat. Cancer Inst. Monogr. 12:343, 1963.

    CAS  PubMed  Google Scholar 

  78. Chen, T.T. and C. Heidelberger, J. Nat. Cancer Inst, 42 : 915, 1969.

    CAS  PubMed  Google Scholar 

  79. Fraley, E.E. and S. Ecker, J. Urol. 106:95, 1971.

    CAS  PubMed  Google Scholar 

  80. Paulson, D.F., E.E. Fraley, J.B. DeKernion and A.S. Robson, Endocrinology 91: 396, 1972.

    Article  Google Scholar 

  81. Cantifanto, Y.M., H.E. Kaufman and Z.S. Zam, J. Virol. 12: 1608, 1973.

    Google Scholar 

  82. Webber, M.M., O.G. Stonington and J. Lehman, Urology 1:561, 1973.

    Article  CAS  PubMed  Google Scholar 

  83. Pollard, M. and P.H. Luckert, J. Nat. Cancer Inst. 54:643, 1975.

    CAS  PubMed  Google Scholar 

  84. Burrows, M.T., J.E. Burns and Y. Susuki, J. Urol. 1:3, 1917.

    Google Scholar 

  85. Pell, H.B. and R. Robinson, Biochem. J. 23:767, 1929.

    Google Scholar 

  86. Lasnitski, I., Nat. Cancer Inst. Monogr. 12:381, 1963.

    Google Scholar 

  87. Lasnitski, I., In: Pierrepoint, C.G. and K. Griffiths (eds.), Some Aspects of the Aetiology and Biochemistry of Prostatic Cancer, Alpha Press, Cardiff, 1970, p. 68.

    Google Scholar 

  88. Fraley, E.E. and D.F. Paulson, J. Urol. 101:735, 1969.

    CAS  PubMed  Google Scholar 

  89. Schroeder, F.H. and S.J. Mackensen, Invest. Urol. 12:176, 1974.

    CAS  PubMed  Google Scholar 

  90. Castro, J.E. and R.A. Sellwood, J. Path. Bact. 113:217, 1974.

    Article  CAS  Google Scholar 

  91. McMahon, M.J., A.V.J. Butler and G.H. Thomas, Acta Endocrinol. (Copenh.) 77:784, 1974.

    CAS  Google Scholar 

  92. Harbitz, T.B., B. Falkanger and S. Sanger, Acta Path. Microbiol. Scand. Sect. A, Suppl. 248:89, 1974.

    Google Scholar 

  93. Webber, M.M., J. Ultrastruct. Res. 50:89, 1975.

    Article  CAS  PubMed  Google Scholar 

  94. McRae, C.V., R. Ghanadian, K. Fotherby and G.D. Chisholm, Er. J. Urol. 45:156, 1973.

    Article  CAS  Google Scholar 

  95. Huggins, C. and P.S. Russell, Endocrinology 39:1, 1946.

    Article  CAS  PubMed  Google Scholar 

  96. Gunn, S.A., T.S. Gould and W.A.D. Anderson, J. Endocrinol. 32:205, 1965.

    Article  CAS  PubMed  Google Scholar 

  97. Grayhack, J.T. and J.M. Lebovitz, Invest. Urol. 5:87, 1967.

    CAS  Google Scholar 

  98. Lawrence, A.M. and R.L. Landau, Endocrinology 77:1119, 1965.

    Article  CAS  PubMed  Google Scholar 

  99. Farnsworth, W.E., In: Boyns, A.R. and K. Griffiths (eds.), Prolactin and Carcinogenesis, Alpha Press, Cardiff, 1972, p. 217.

    Google Scholar 

  100. Mawhinney, M.G., J.A. Belis, J.A. Thomas and J.W. Lloyd, J. Pharmacol. Exp. Ther. 192:242, 1975.

    CAS  PubMed  Google Scholar 

  101. Asano, M., S. Kanzakim, E. Sekiguchi and T. Tasaka, J. Urol. 106:248, 1971.

    CAS  PubMed  Google Scholar 

  102. Lostroh, A.J., Proc. Nat. Acad. Sci. U.S.A. 60:1312, 1968.

    Article  CAS  Google Scholar 

  103. Fuller, D.J., K.M.B. Chan and G.H. Thomas, J. Endocrinol. 63:59P, 1974.

    Google Scholar 

  104. Hansson, V., K.J. Tveter, A. Attramadal and O. Torgerson, Acta Endocrinol. (Copenh.) 68:79, 1971.

    CAS  Google Scholar 

  105. Geller, J. and C. Worthman, Acta Endocrinol. (Copenh.) Suppl. 177:4, 1973

    Google Scholar 

  106. Rosen, V., I. Jung, E.-E. Baulieu and P. Robel, Compt. Rend. 248:4, 1975.

    Google Scholar 

  107. Mainwaring, W.I.P. and E.G.P. Milroy, J. Endocrinol. 57:371, 1973.

    Article  CAS  PubMed  Google Scholar 

  108. Steins, P., M. Kreig, H.J. Hollmann and K.D. Voigt, Acta Endocrinol. (Copenh.) 75:773, 1974.

    CAS  Google Scholar 

  109. Mobbs, B.G., I.E. Johnson and J.G. Connolly, J. Steroid Biochem. 6:453, 1975.

    Article  CAS  PubMed  Google Scholar 

  110. Mobbs, B.G., I.E. Johnson and J.G. Connolly, Urology 3: 105, 1974.

    Article  CAS  PubMed  Google Scholar 

  111. Wittlif, J.L., Seminars in Oncology 1:109, 1974.

    Google Scholar 

  112. Leclercq, G., J.C. Heusen, M.C. Deboel and W.H. Matteiem, Br. Med. J. 1:189, 1975.

    Article  Google Scholar 

  113. McGuire, W.L., P.P. Carbone, M.E. Sears and G.C. Escher, In: McGuire, W.L., P.P. Carbone and E.P. Vollmer (eds.), Estrogen Receptors in Human Breast Cancer, Raven Press, New York, 1975, p.110.

    Google Scholar 

  114. Orestano, F., J.E. Altwein, P. Knapstein and K. Bandhauer, J. Steroid Biochem. 6:845, 1975.

    Article  CAS  PubMed  Google Scholar 

  115. Voigt, K. and S.L. Hsia, Endocrinology 92:1216, 1973.

    Article  CAS  PubMed  Google Scholar 

  116. Hisaeter, P.A., Invest. Urol. 12:33, 1974.

    Google Scholar 

  117. Muntzing, J., S.K. Shukla, T.M. Chu, A. Mittelman and G.P. Murphy, Invest. Urol. 12:65, 1974.

    CAS  PubMed  Google Scholar 

  118. Boris, A., J.W. Scott, L. de Martino and D.C. Cox, Acta Endocrinol. (Copenh.) 72:604, 1973.

    CAS  Google Scholar 

  119. Neri, R. and M. Monahan, Invest. Urol. 10:123, 1972.

    CAS  PubMed  Google Scholar 

  120. Neri, R., K. Florance, P. Koziol and S. van Cleave, Endocrinology 9:427, 1972.

    Article  Google Scholar 

  121. Mainwaring, W.I.P., F.R. Mangan, P.A. Feherty and M. Friefeld, Mol. Cell. Endocrinol. 1:113, 1974.

    Article  CAS  PubMed  Google Scholar 

  122. Varkarakis, M.J., R.Y. Kirdani, H. Yamanaka, G.P. Murphy and A.A. Sandberg, Invest. Urol. 12:275, 1975.

    CAS  PubMed  Google Scholar 

  123. Rann, F., Kastrationens betydning i prostata hypertrofiens behandling, H. Aschehoug and Co., Kristiania, 1894.

    Google Scholar 

  124. White, J.W., Ann. Surg. 22:1, 1895.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Androgen Physiology Department, Imperial Cancer Research Fund Lincoln’s Inn Fields, London, WC2A 3PX, UK

    W. Ian P. Mainwaring

Authors
  1. W. Ian P. Mainwaring
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Michigan Medical School, Ann Arbor, Michigan, USA

    K. M. J. Menon

  2. Parke Davis Research Laboratories, Ann Arbor, Michigan, USA

    Jerry R. Reel

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Plenum Press, New York

About this chapter

Cite this chapter

Mainwaring, W.I.P. (1976). The Relevance of Studies on Androgen Action to Prostatic Cancer. In: Menon, K.M.J., Reel, J.R. (eds) Steroid Hormone Action and Cancer. Current Topics in Molecular Endocrinology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2601-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-2601-4_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2603-8

  • Online ISBN: 978-1-4684-2601-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation