Adrenergic and Cholinergic Inputs to the Amygdala: Role in Gonadotropin Secretion

  • J. Borrell
  • F. Piva
  • L. Martini
Part of the Current topics in Molecular Endocrinology book series (CTME, volume 3)


Several data suggest that the limbic structures in general and the amygdala in particular may be involved in the regulation of LH and FSH secretion. On the basis of lesion and stimulation experiments, it has been postulated that, in adult animals, the amygdala may exert either stimulatory or inhibitory influences on gonadotropin release (for references, see: Schiaffini and Martini, 1972; Smith and Lawton, 1972; Kawakami and Terasawa, 1972; Karakami et al., 1973; Ellendorf et al., 1973; Kanematsu et al., 1974). A participation of the amygdala in the development of puberty has also been suggested (Critchlcw and Bar-Sela, 1967), but this has been denied by others (Bloch and Ganong, 1971; Relkin, 1971 a and b). In addition, the hypothesis has been put forward that the amygdala might participate in the feedback mechanisms through which sex steroids control LH and FSH output (for references, see: Piva et al., 1973; McEwen and Pfaff, 1973; Terasawa and Kawakami, 1974; Parvizi and Ellendorf, 1975). Finally, it has been reported that the oxydative metabolism of the amygdala may be influenced by castration as well as by the administration of sex steroids and of anterior pituitary hormones (Schiaffini and Martini, 1972).


Cocoa Butter Gonadotropin Secretion Dopaminergic Receptor Cholinergic Input Dopamine Receptor Blocker 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • J. Borrell
    • 1
    • 2
  • F. Piva
    • 1
  • L. Martini
    • 1
  1. 1.Departments of Endocrinology and PharmacologyUniversity of MilanoMilanoItaly
  2. 2.Fellow of the March FoundationMadridSpain

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