Advertisement

Analogs of Somatostatin Part A. Chemistry and In Vitro Results

  • H. Immer
  • N. A. Abraham
  • V. Nelson
  • K. Sestanj
  • M. Götz
  • P. Brazeau
  • J. B. Martin
Part of the Current topics in Molecular Endocrinology book series (CTME, volume 3)

Abstract

Recently, we reported on the synthesis of Somatostatin by a classical fragment approach (Immer et al., 1974). This method avoids the problematic cyclization of dihydrosomatostatin (Rivier, J.E.F., 1974, Fujii, N. and Yajima, H., 1975) and leads to the desired product in high yield. Essentially, the same synthetic scheme was employed for the preparation of three groups of somatostatin analogs discussed here:
  1. 1)

    Shortened Analogs of Somatostatin.

     
  2. 2)

    Elongated Analogs of Somatostatin

     
  3. 3)

    Retroenantio Analogs of Somatostatin Derivatives.

     

Keywords

Pituitary Cell Cyclic Peptide Anterior Pituitary Cell Terminal Carboxy Inhibitor Cone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brazeau, P., Vale, W., Rivier, J. and Guillemin, R. (1974) Biochem. Biophys. Res. Commun. 60, 1202–1207.PubMedCrossRefGoogle Scholar
  2. Fujii, N. and Yajimo, H. (1975) Chem. Pharm. Bull. 23, 1596–1603.PubMedCrossRefGoogle Scholar
  3. Hechter, O., Kato, T., Nakagawa, S.H., Yong, F. and Flouret, G. (1975) Proc. Nat. Sci. USA 72, 563–566.CrossRefGoogle Scholar
  4. Immer, H.U., Sestanj, K., Nelson, V.R. and Götz, M. (1974) Helv. Chim. Acta. 57, 730–734.PubMedCrossRefGoogle Scholar
  5. Rivier, J.E.F. (1974) J. Amer. Chem. Soc. 96, 2986–2991.CrossRefGoogle Scholar
  6. Rudinger, J. (1971) In: Drug Design (E.J. Ariëns ed.) vol. 2, Academic Press New York and London, pp 394–397 and 368–369.Google Scholar
  7. Shemyakin, M.M., Ovchinnikov Yu. A; and Yvanov, V.T. (1969) Angew. Chem. Internat. Edit. 8, 492–499.CrossRefGoogle Scholar
  8. Vale, W., Grant, G., Amoss, M., Blackwell, R. and Guillemin, R. (1972) Endocrinology 91, 562–5.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • H. Immer
    • 1
  • N. A. Abraham
    • 1
  • V. Nelson
    • 1
  • K. Sestanj
    • 1
  • M. Götz
    • 1
  • P. Brazeau
    • 2
  • J. B. Martin
    • 2
  1. 1.Ayerst Research LaboratoriesSt. LaurentCanada
  2. 2.Research InstituteMontreal General HospitalMontrealCanada

Personalised recommendations