Analogs of Somatostatin Part A. Chemistry and In Vitro Results
Part of the Current topics in Molecular Endocrinology book series (CTME, volume 3)
Recently, we reported on the synthesis of Somatostatin by a classical fragment approach (Immer et al., 1974). This method avoids the problematic cyclization of dihydrosomatostatin (Rivier, J.E.F., 1974, Fujii, N. and Yajima, H., 1975) and leads to the desired product in high yield. Essentially, the same synthetic scheme was employed for the preparation of three groups of somatostatin analogs discussed here:
Shortened Analogs of Somatostatin.
Elongated Analogs of Somatostatin
Retroenantio Analogs of Somatostatin Derivatives.
KeywordsPituitary Cell Cyclic Peptide Anterior Pituitary Cell Terminal Carboxy Inhibitor Cone
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Plenum Press, New York 1976