Role of Prostaglandins (PGs) in the Control of Adenohypophyseal Hormone Secretion

  • S. M. McCann
  • S. R. Ojeda
  • P. G. Harms
  • J. E. Wheaton
  • D. K. Sundberg
  • C. P. Fawcett
Part of the Current topics in Molecular Endocrinology book series (CTME, volume 3)


With the realization of the wide-spread distribution and biological action of the prostaglandins, it was natural to search for possible effects of these agents on the hypothalamic-pituitary unit In this communication we will review the evidence which indicates that prostaglandins can act both on the pituitary and on the hypothalamus to alter the release of adenohypophyseal hormones. The review will summarize the present status with respect to ACTH, TSH and growth hormone but will concentrate on the role of the prostaglandins on the secretion of FSH, LH and prolactin with which we have been particularly concerned in this laboratory.


Growth Hormone ACTH Secretion Plasma Prolactin Prolactin Release Intraventricular Injection 
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  1. Brown, M., and Hedge, G.A. (1974) Endocrinology 95, 1392–1397.PubMedCrossRefGoogle Scholar
  2. Carlson, J.C., Barcikowski, B., and McCracken, J.A. (1973) J. Reprod. Fert. 34, 357–361.CrossRefGoogle Scholar
  3. Carlson, J.C., Barcikowski, B., Cargill, U., and McCracken, J.A. (1974) J. Clin. Endocrinol. Metab. 39, 399-PubMedCrossRefGoogle Scholar
  4. Chobsieng, P., Naor, Z., Zor, U., and Lindner, H.R. (1975) Neuroendocrinology 17, 12–17.PubMedCrossRefGoogle Scholar
  5. DeWied, D., Witter, A., Versteeg, D.H.G., and Mulder, A.H. (1969) Endocrinology 85, 561–569.CrossRefGoogle Scholar
  6. Dupont, A., and Chavancy, G. (1972) Prog IV Interntl. Cong. Endo., p. 84.Google Scholar
  7. Eskay, R.L., Warberg, J., Mical, R.S., and Porter, J.C. (in press), Endocrinology.Google Scholar
  8. Harms, P.G., Ojeda, S.R., and McCann, S.M. (1973) Science 181, 760–761.PubMedCrossRefGoogle Scholar
  9. Harms, P.G., Ojeda, S.R., and McCann, S.M. (1974) Endocrinology 94, 1459–1464.PubMedCrossRefGoogle Scholar
  10. Harms, P.G., Ojeda, S.R., and McCann, S.M. (in press) Endocrinology.Google Scholar
  11. Hedge, G.A. (1972) Endocrinology 91, 925–933.PubMedCrossRefGoogle Scholar
  12. Hertelendy, F. (1971) Acta Endocrinol. 68, 355–362.PubMedGoogle Scholar
  13. Hertelendy, F., Todd, H., Ehrhart, K., and Blute, R. (1972) Prostaglandins 2, 79-PubMedCrossRefGoogle Scholar
  14. Ito, H., Momse, G., Katayama, T., Takagishi, H., Ito, L., Nakajima, H., and Takei, Y. (1971) J. Clin. Endocrinol. Metab. 32, 857–859.PubMedCrossRefGoogle Scholar
  15. Louis, T.M., Stellflug, J.N., Tucker, H.A., and Hafs, H.D. (1974) Proc. Soc. Exp. Biol. Med. 147, 128–133.PubMedGoogle Scholar
  16. MacLeod, R.M., and Lehmeyer, J.E. (1970) Proc. Natl. Acad. Sci. U.S.A. 67, 1172–1179.PubMedCrossRefGoogle Scholar
  17. Makino, T. (1973) Am. J. Obstet. Gynecol. 115, 606–614.PubMedGoogle Scholar
  18. Ojeda, S.R., Harms, P.G., and McCann, S.M. (1974a) Endocrinology 95, 613–618.PubMedCrossRefGoogle Scholar
  19. Ojeda, S.R., Harms, P.G., and McCann, S.M. (1974b) Endocrinology 95, 1694–1703.PubMedCrossRefGoogle Scholar
  20. Ojeda, S.R., Harms, P.G., and McCann, S.M. (1974c) Prostaglandins 8, 545–552.PubMedCrossRefGoogle Scholar
  21. Ojeda, S.R., Harms, P.G., and McCann, S.M. (in press) Endocrinology.Google Scholar
  22. Ojeda, S.R., Wheaton, J.E., and McCann, S.M. (1975) Neuroendocrinology 17, 283–287.PubMedCrossRefGoogle Scholar
  23. Peng, T.C., Six, K.M., and Munson, P.L. (1970) Endocrinology 86, 561–569.CrossRefGoogle Scholar
  24. Ratner, A., Wilson, M.C., Srivastava, L., and Peake, G.T. (1974) Prostaglandins 5, 165-CrossRefGoogle Scholar
  25. Sato, T., Jyujo, T., Iesaka, T., Ishikawa, J., and Igarashi, M. (1974) Prostaglandins 5, 483–490.PubMedCrossRefGoogle Scholar
  26. Sato, T., Hirono, M., Jyujo, T., Iesaka, T., Taya, K., and Igarashi, M. (1975a) Endocrinology 96, 45–49.PubMedCrossRefGoogle Scholar
  27. Sato, T., Jyujo, T., Kawarai, Y., and Asai, T. (1975b) Am. J. Obstet. Gynecol. 122, 637–641.PubMedGoogle Scholar
  28. Schofield, J.C. (1970) Nature 228, 179–180.PubMedCrossRefGoogle Scholar
  29. Sundberg, D.K., Fawcett, C.P., Illner, P., and McCann, S.M. (1975). Proc. Soc. Exp. Biol. Med. 148, 54–59PubMedGoogle Scholar
  30. Tal, E., Szabo, M., and Burke, G. (1974) Prostaglandins 5, 175–182.CrossRefGoogle Scholar
  31. Tsafrini, A., Koch, Y., and Lindner, H.R. (1973) Prostaglandins 3, 461–467.CrossRefGoogle Scholar
  32. Tucker, H.A., Vines, D.T., Stellflug, J.N., and Convey, E.M. (1975) Proc. Soc. Exp. Biol. Med. 149, 462–469.PubMedGoogle Scholar
  33. Vale, W., Grant, G., Amoss, M., Blackwell, R., and Guillemin, R. (1972) Endocrinology 91, 562–572.PubMedCrossRefGoogle Scholar
  34. Yue, D.K., Smith, I.D., Turtle, J.R., and Shearman, R.P. (1974) Prostaglandins 8, 387–395.PubMedCrossRefGoogle Scholar
  35. Zor, U., Kaneko, T., Schneider, H.P.G., McCann, S.M., Lowe, I.P., Bloom, G., Borland, B., and Field, J.B. (1969) Proc. Nat. Acad. Sci. U.S.A. 63, 918–925.CrossRefGoogle Scholar
  36. Zor, U., Kaneko, T., Schneider, H.P.G., McCann, S.M., and Field, J.B. (1970) J. Biol. Chem. 245 2883–2888.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • S. M. McCann
    • 1
  • S. R. Ojeda
    • 1
  • P. G. Harms
    • 1
  • J. E. Wheaton
    • 1
  • D. K. Sundberg
    • 1
  • C. P. Fawcett
    • 1
  1. 1.Southwestern Medical SchoolThe University of Texas Health Science Center at DallasDallasUSA

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