Episodic GH Secretion: Evidence for a Hypothalamic Dopaminergic Mechanism

  • John O. Willoughby
  • Joseph B. Martin
Part of the Current topics in Molecular Endocrinology book series (CTME, volume 3)


With the development of specific radioimmunoassays for human anterior pituitary (AP) hormones, it became apparent that concentrations of the various hormones in random blood samples often varied widely. It was subsequently recognized by frequent sampling, that blood levels of the AP hormones fluctuated abruptly. This phenomenon, originally described for growth hormone (GH) and adrenocorticotrophic hormone (ACTH) is also demonstrated by other AP hormones, and is presumed to be due to intermittent rather than continuous hormonal secretion. Abrupt changes in hormonal clearance rate, peripheral storage, or excretion which might contribute to such a phenomenon have not been sought extensively, but would appear to be unlikely factors.


Growth Hormone Growth Hormone Secretion Anterior Pituitary Hormone Secretory Profile Ultradian Rhythm 


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  1. 1.
    Blake, C.A. and Sawyer, C.H. (1974) Endocrinology 94, 730–736.PubMedCrossRefGoogle Scholar
  2. 2.
    Blazquez, E., Simon, F.A., Blázquez, M. and Foà, P.P. (1974) Proc. Soc. Exp. Biol. Med. 147, 780–783.PubMedGoogle Scholar
  3. 3.
    Boyar, R.M., Finkelstein, J.W., Roffwarg, H., Kapen, S., Weitzman, E.D. and Hellman, H. (1972a) New Engl. J. Med. 287, 582–586.PubMedCrossRefGoogle Scholar
  4. 4.
    Boyar, R., Perlow, M., Hellman, L., Kapen, S. and Weitzman, E. (1972b) J. Clin. Endocrinol. Metab. 35, 73–81.PubMedCrossRefGoogle Scholar
  5. 5.
    Brown, M.R. and Hedge, G.A. (1972) Neuroendocrinology 9, 158–174.PubMedCrossRefGoogle Scholar
  6. 6.
    Butler, W.R., Krey, L.C., Espinosa-Campos, J. and Knobil, E. (1975a) Endocrinology 96, 1094–1098.PubMedCrossRefGoogle Scholar
  7. 7.
    Butler, W.R., Krey, L.C., Lu, K.H., Peckham, W.D. and Knobil, E. (1975b) Endocrinology 96, 1099–1105.CrossRefGoogle Scholar
  8. 8.
    Collu, R., Fraschini, F., Visconti, P. and Martini, L. (1972) Endocrinology 90, 1231–1237.PubMedCrossRefGoogle Scholar
  9. 9.
    Dierschke, D.J., Battacharya, A.N., Atkinson, L.E. and Knobil, E. (1970) Endocrinology 87, 850–853.PubMedCrossRefGoogle Scholar
  10. 10.
    Dunn, J.D., Schindler, W.J., Hutchins, M.D., Scheving, L.E. and Turpen, C. (1973) Neuroendocrinology 13, 69–78.PubMedCrossRefGoogle Scholar
  11. 11.
    Finkelstein, J.W., Roffwarg, H.P., Boyar, R.M., Kream, J. and Hellman, L. (1972) J. Clin. Endocrinol. Metab. 35, 665–670.PubMedCrossRefGoogle Scholar
  12. 12.
    Frohman, L.A. and Bernardis, L.L. (1970) Endocrinology 86, 305–312.PubMedCrossRefGoogle Scholar
  13. 13.
    Gallagher, T.F., Yoshida, K., Roffwarg, H.D., Fukushima, D.K., Weitzman, E.D. and Hellman, L. (1973) J. Clin. Endocrinol. Metab. 36, 1058–1073.PubMedCrossRefGoogle Scholar
  14. 14.
    Gay, V.L. and Sheth, N.A. (1972) Endocrinology 90, 158–162.PubMedCrossRefGoogle Scholar
  15. 15.
    Glick, S.M. and Goldsmith, S. (1968) In: Growth Hormone (A. Pecile and E.E. Müller, eds.) I.C.S. 158, Excerpta Medica, Amsterdam, pp 84–88.Google Scholar
  16. 16.
    Halász, B. and Pupp, L. (1965) Endocrinology 77, 553–562.PubMedCrossRefGoogle Scholar
  17. 17.
    Halász, B., Slusher, M.A. and Gorski, R.A. (1967) Neuroendocrinology 2, 43–55.CrossRefGoogle Scholar
  18. 18.
    Halász, B., Schalch, D.S., and Gorski, R.A. (1971) Endocrinology 89, 198–203.PubMedCrossRefGoogle Scholar
  19. 19.
    Hellman, L., Nakada, F., Curti, J., Weitzman, E.D., Kream, J., Roffwarg, H., Ellman, S., Fukushima, D.K. and Gallagher, T.F. (1970) J. Clin. Endocrinol. Metab. 30, 411–422.PubMedCrossRefGoogle Scholar
  20. 20.
    Honda, Y., Takahashi, K., Takahashi, S., Azumi, K., Irie, M., Sakuma, M., Tsushima, T. and Shizumi, K. (1969) J. Clin. Endocrinol. Metab. 29, 20–29.PubMedCrossRefGoogle Scholar
  21. 21.
    Krey, L.C., Butler, W.R. and Knobil, E. (1975a) Endocrinology 96, 1073–1087.PubMedCrossRefGoogle Scholar
  22. 22.
    Krey, L.C., Lu, K-H., Butler, W.R., Hotchkiss, J., Piva, F. and Knobil, E. (1975b) Endocrinology 96, 1088–1093.PubMedCrossRefGoogle Scholar
  23. 23.
    Krieger, D.T., Ossowski, R., Fogel, M. and Allen, W. (1972) J. Clin. Endocrinol. Metab. 35, 619–623.PubMedCrossRefGoogle Scholar
  24. 24.
    Maclntyre, H.B. and Odell, W.D. (1974) Neuroendocrinology 16, 8–21.CrossRefGoogle Scholar
  25. 25.
    Martin, J.B., Renaud, L.P. and Brazeau, P. (1974) Science 186, 538–540.PubMedCrossRefGoogle Scholar
  26. 26.
    Mitchell, J.A., Hutchins, M., Schindler, W.J. and Critchlow, V. (1973) Neuroendocrinology 12, 161–173.PubMedCrossRefGoogle Scholar
  27. 27.
    Neill, J.D. (1972) Endocrinology 90, 568–572.PubMedCrossRefGoogle Scholar
  28. 28.
    Nett, T.M., Akbar, A.M. and Niswender, G.D. (1974) Endocrinology 94, 713–718.PubMedCrossRefGoogle Scholar
  29. 29.
    Parker, D.C., Sassin, J.F., Mace, J.W., Gotlin, R.W. and Rossman, L.G. (1969) J. Clin. Endocrinol. Metab. 29, 871–874.PubMedCrossRefGoogle Scholar
  30. 30.
    Parker, D.C., Morishima, M., Koerker, D.J., Gale, C.C. and Goodner, C.J. (1972) Endocrinology 91, 1462–1467.PubMedCrossRefGoogle Scholar
  31. 31.
    Parker, D.C., Rossman, L.G. and Vanderlaan, E.F. (1973) J. Clin. Endocrinol. Metab. 38, 646–651.CrossRefGoogle Scholar
  32. 32.
    Quabbé, H-J., Schilling, E. and Helge, H. (1966) J. Clin. Endocrinol. Metab. 26, 1173–1177.PubMedCrossRefGoogle Scholar
  33. 33.
    Relkin, R. (1972) J. Endocrinol. 53, 289–293.PubMedCrossRefGoogle Scholar
  34. 34.
    Rubin, R.T., Kales, A., Adler, R., Fagan, T. and Odell, W. (1972) Science 175, 196–198.PubMedCrossRefGoogle Scholar
  35. 35.
    Sassin, J., Jacoby, J.H., Finkelstein, J., Fukushima, D. and Weitzman, E. (1971) Neurology 21, 431–432.Google Scholar
  36. 36.
    Sassin, J.F., Frantz, A.G., Weitzman, E.D. and Kapen, S. (1972) Science 177, 1205–1207.PubMedCrossRefGoogle Scholar
  37. 37.
    Schindler, W.J., Hutchins, M.O. and Septimus, E.J. (1972) Endocrinology 91, 483–490.PubMedCrossRefGoogle Scholar
  38. 38.
    Smythe, G.A., Brandstater, J.F. and Lazarus, L. (1975) Neuroendocrinology 17, 245–257.PubMedCrossRefGoogle Scholar
  39. 39.
    Sorrentino, S., Schalch, D.S. and Reiter, R.J. (1971) In: Growth and Growth Hormone (A. Pecile and E.E. Muller, eds) I.C.S. 244, Excerpta Medica, Amsterdam, pp 330–348.Google Scholar
  40. 40.
    Takahashi, Y., Kipnis, D.M. and Daughaday, W.H. (1968) J. Clin. Invest. 47, 2079–2090.PubMedCrossRefGoogle Scholar
  41. 41.
    Tannenbaum, G. (1975) Ph.D. Thesis, Dept. of Psychology, McGill University.Google Scholar
  42. 42.
    Tannenbaum, G. and Martin, J.B. (1975a) Fed. Proc. 34, 273.Google Scholar
  43. 43.
    Tannenbaum, G. and Martin, J.B. (1975b) Endocrinology (submitted for publication).Google Scholar
  44. 44.
    Tannenbaum, G. and Martin, J.B. (1975c) Endocrinology (submitted for publication).Google Scholar
  45. 45.
    Vanhaelst, L., Golstein, J., Van Cauter, E., L’Hermite, M. and Robyn, C. (1973) Compt. Rend. Acad. Sci. 276, 1875–1877.Google Scholar
  46. 46.
    Weiner, R.I. (1973) In: Drug Effects on Neuroendocrine Regulation (E. Zimmerman, W.H. Gispen, B.H. Marks and D. de Weid, eds.) Prog. Brain Res. 39, Excerpta Medica, Amsterdam, pp 165–170.CrossRefGoogle Scholar
  47. 47.
    Willoughby, J.O., Martin, J.B., Renaud, L.P. and Brazeau, P. (1975) Endocrinology (submitted for publication).Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • John O. Willoughby
    • 1
  • Joseph B. Martin
    • 1
  1. 1.Division of Neurology, Department of Medicine, Montreal General HospitalMcGill UniversityMontrealCanada

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