Episodic GH Secretion: Evidence for a Hypothalamic Dopaminergic Mechanism

  • John O. Willoughby
  • Joseph B. Martin
Part of the Current topics in Molecular Endocrinology book series (CTME, volume 3)


With the development of specific radioimmunoassays for human anterior pituitary (AP) hormones, it became apparent that concentrations of the various hormones in random blood samples often varied widely. It was subsequently recognized by frequent sampling, that blood levels of the AP hormones fluctuated abruptly. This phenomenon, originally described for growth hormone (GH) and adrenocorticotrophic hormone (ACTH) is also demonstrated by other AP hormones, and is presumed to be due to intermittent rather than continuous hormonal secretion. Abrupt changes in hormonal clearance rate, peripheral storage, or excretion which might contribute to such a phenomenon have not been sought extensively, but would appear to be unlikely factors.


Growth Hormone Growth Hormone Secretion Anterior Pituitary Hormone Secretory Profile Ultradian Rhythm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • John O. Willoughby
    • 1
  • Joseph B. Martin
    • 1
  1. 1.Division of Neurology, Department of Medicine, Montreal General HospitalMcGill UniversityMontrealCanada

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