Role of Sex Steroids on LH and FSH Secretion in the Rat

  • L. Ferland
  • J. Drouin
  • F. Labrie
Part of the Current topics in Molecular Endocrinology book series (CTME, volume 3)


Elucidation of the structure of LH-RH (Matsuo et al., 1971; Burgus et al., 1971) has opened new possibilities for studies of the factors involved in the control of LH and FSH secretion. This presentation will attempt to summarize the data describing the role of estrogens and androgens as specific and important modulators of gonadotropin secretion. Using the rat as model, evidence vill be presented of a specific action of these steroids at the hypothalamic and pituitary levels.


Estrous Cycle Gonadotropin Secretion Estradiol Benzoate Pituitary Level Pituitary Sensitivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Baldwin, D.M., Ramirez, V.D. and Sawyer, C.H. (1974) Fed. Proc. 33, 212.Google Scholar
  2. Beyer, C., Jaffe, R.B. and Gay, V.L. (1972) Endocrinology 91, 1372–1375.PubMedCrossRefGoogle Scholar
  3. Beyer, C., Cruz, M.L., Gay, V.L. and Jaffe, R.B. (1974) Endocrinology, 95, 722–727.PubMedCrossRefGoogle Scholar
  4. Bogdanove, E.M. (1967) Anat. Rec., 157, 117–136.PubMedCrossRefGoogle Scholar
  5. Borgeat, P., Chavancy, G., Dupont, A., Labrie, F., Arimura, A. and Schally, A.V. (1972) Proc. Nat. Acad. Sci. 69, 2677–2681.PubMedCrossRefGoogle Scholar
  6. Brown-Grant, K., Exley, D. and Naftolin, F. (1970) J. Endocrinol. 48, 295–296.PubMedCrossRefGoogle Scholar
  7. Burgus, R., Butcher, M., Ling, N., Monahan, M., Rivier, J., Fellows, R., Amoss, M., Blackwell, R., Vale, W. and Guillemin, R. (1971) C.R. Acad. Sci. (Paris) 273, 1611–1613.Google Scholar
  8. Debeljuk, L., Arimura, A. and Schally, A.V. (1972) Endocrinology, 90, 1578–1581.PubMedCrossRefGoogle Scholar
  9. Denef, C., Magnus, C. and McEwen, B.S. (1973) J. Endocrinol, 59, 605–621.PubMedCrossRefGoogle Scholar
  10. Drouin, J., and Labrie, F. (1976) Endocrinology, submitted for publication.Google Scholar
  11. Eldridge, J.C. and Mahesh, B.V. (1974) Biol. Reprod. 11, 385–397.CrossRefGoogle Scholar
  12. Everett, J.W. (1948) Endocrinology 43, 389–392.PubMedCrossRefGoogle Scholar
  13. Ferland, L., Borgeat, P., Labrie, F., Bernard, J., De Léan, A. and Raynaud, J.P. (1975) Mol. Cell. Endocrinol. 2, 107–115.PubMedCrossRefGoogle Scholar
  14. Ferland, L., Kelly, P. and Labrie, F. (1976) Endocrinology, submitted for publication.Google Scholar
  15. Jewelewicz, R., Ferin, M., Vande Wiele, R.L., Dyrenfurth, I. and Warren, M. (1974) Fértil, and Steril. 25, 290–291.Google Scholar
  16. Kamberi, I.A. and McCann, S.M. (1969) Fed. Proc. 28, 382.Google Scholar
  17. Kingsley, T.R. and Bogdanove, E.M. (1973) Endocrinology 93, 1398–1403.PubMedCrossRefGoogle Scholar
  18. Legan, S.J., Gay, V.L. and Midgley, A.R. Jr. (1973) Endocrinology 93, 781–785.PubMedCrossRefGoogle Scholar
  19. Lee, P.S., Jaffe, R.B., Midgley, A.R. Jr, Kohen, F. and Niswender, G.D. (1972) J. Clin. End. Metab. 35, 636–641.CrossRefGoogle Scholar
  20. Mahesh, V., Muldoon, T.G., Eldridge, J.C. and Korach, K.A. (1972) In “Saxena, B.B., Beling, C.G. and Gandy, H.M. (eds), Gonadotropins, Wiley-Interscience, N.Y.) p. 730–748.Google Scholar
  21. Matsuo, H., Baba, Y., Nair, R.M.G., Arimura, A. and Schally, A.V. (1971) Biochem. Biophys. Res. Commun. 43, 1334–1339.PubMedCrossRefGoogle Scholar
  22. Naftolin, F., Brown-Grant, K. and Corker, S.C. (1972) J. Endocrinol., 53, 17–30.PubMedCrossRefGoogle Scholar
  23. Negro-Vilar, A., Ojeda, S.R. and McCann, S.M. (1973) Endocrinology 93, 729–735.PubMedCrossRefGoogle Scholar
  24. Nillius, S.J. and Wide, L. (l97l) J. Obstet. Gynec. Brit. Common. 78, 922–927.Google Scholar
  25. Peterson, N.T.Jr., Midgley, A.R.Jr. and Jaffe, R.B. (1968) J. Clin. End. Metab. 28, 473–1478.CrossRefGoogle Scholar
  26. Ramirez, V.D. and McCann, S.M. (1963) Endocrinology 72: 452–455.PubMedCrossRefGoogle Scholar
  27. Schally, A.V., Carter, W.H., Arimura, A. and Borers, C.Y. (1967) Endocrinology _&, 1173–1176.Google Scholar
  28. Schally, A.V., Kastin, A.J. and Arimura, S. (l97l) Fertil. Steril. 22, 703–721.Google Scholar
  29. Smith, E.R. and Davidson, J.M. (1967) Am. J. Physiol. 212, 1385–1390.PubMedGoogle Scholar
  30. Smith, E.R., and Davidson, J.M. (1974) Neuroendocrinology 14, 369–373.PubMedCrossRefGoogle Scholar
  31. Swerdloff, R.S. and Odell, W.D. (1968) Lancet 2, 683–687.PubMedCrossRefGoogle Scholar
  32. Swerdloff, R.S., Walsh, P.C. and Odell, W.D. (1972) Steroids 20, 13–22.PubMedCrossRefGoogle Scholar
  33. Swerdloff, R.S. and Walsh, P.C. (1973) Acta Endocrinologica 73, 11–21.PubMedGoogle Scholar
  34. Yen, S.S.C., VanderBerg, C., Rebor, R. and Ehara, Y. (1972) J. Clin. Endocrinol. Metab. 35, 931–934.PubMedCrossRefGoogle Scholar
  35. Zanisi, M., Motta, M. and Martini, L. (1973) J. Endocrinol., 315–316.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • L. Ferland
    • 1
  • J. Drouin
    • 1
  • F. Labrie
    • 1
  1. 1.Medical Research Council Group in Molecular, Endocrinology, CHULCanada

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