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Effects of FSH on Levels of Androgen Binding Protein in the Testis

  • Irving B. Fritz
  • Bozena Kopec
  • Kam Lam
  • Richard G. Vernon
Part of the Current Topics in Molecular Endocrinology book series (CTME, volume 1)

Abstract

Preliminary observations reported at meetings held in 1972 (1, 2) indicated the existence of at least two classes of androgen binding proteins (ABP) in seminiferous tubules and in extracts from tubules isolated from testes of recently hypophysectomized rats. We observed that most of the androgen binding protein activity in testis was associated with the extracellular fractions, presumably in tubular fluid (2). We were somewhat disconcerted by the low values in germinal cells, since our initial motivation for performing these experiments was based upon hopes that we might identify those germinal cells which were potentially responsive to androgens by determining which cells contained the high affinity ABP.

Keywords

Binding Capacity Sertoli Cell Seminiferous Tubule Supernatant Fraction Testis Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Vernon, R. G., Dorrington, J. H., and Fritz, I. B., IV International Congress of Endocrinology, Washington, D. C., Abstract 200, 1972.Google Scholar
  2. 2.
    Vernon, R. G., Kopec, B. and Fritz, I. B., J. Endocrinol. 57:IIp, 1973. (Proceedings of the Society for Endocrinol., D. Hull, 4–7 Sept. 1972.)Google Scholar
  3. 3.
    Vernon, R. G., Kopec, B., and Fritz, I. B., Molec. and Cellular Endocrinol., in press, 1974.Google Scholar
  4. 4.
    French, F. S. and Ritzen, E. M., Endocrinol., 93: 88, 1973.CrossRefGoogle Scholar
  5. 5.
    French, F. S., and Ritzen, E. M., J. Reprod. Fertil 32: 479, 1973.PubMedCrossRefGoogle Scholar
  6. 6.
    Van Demark, N. L. and Free, M. J. In: The Testis, Johnson, A. D., Gomes, W. R. and Van Demark, Vol. III, Academic Press, New York, 1971, p. 233.Google Scholar
  7. 7.
    Dorrington, J. H., and Fritz, I. B., Endocrinol. 94: 395, 1974.CrossRefGoogle Scholar
  8. 8.
    Cattanach, B. M., Pollard, C. E., and Hawkes, S. G., Cytogenetics 10: 318, 1971.PubMedCrossRefGoogle Scholar
  9. 9.
    Murphy, H. D., Proc. Soc. Exptl. Biol. Med. 118: 1202, 1965.Google Scholar
  10. 10.
    Dorrington, J. H., Vernon, R. G. and Fritz, I. B., Biochem. Biophys. Res. Commun. 46: 1523, 1972.PubMedCrossRefGoogle Scholar
  11. 11.
    Castro, A. E., Seiguer, A. C., and Mancini, R. E., Proc. Soc. Exptl. Biol. Med. 133: 582, 1972.Google Scholar
  12. 12.
    Castro, A. E., Alonso, A., and Mancini, R. E., J. Endocrinol. 52: 129, 1972.PubMedCrossRefGoogle Scholar
  13. 13.
    Hansson, V., Reusch, E., Trygstad, O., Torgerson, O., Ritzen, E. M., and French, F. S., Nature New Biology 246: 56, 1973.PubMedGoogle Scholar
  14. 14.
    French, F. S., This volume, p. 258.Google Scholar
  15. 15.
    Sanborn, B. M., This volume, p. 283.Google Scholar
  16. 16.
    Imai, K., Gunma Symposium Endocrinol. 7: 169, 1970.Google Scholar
  17. 17.
    Brinkman, A. O., Mulder, E., Lamers-Stahlhofen, G. J. M., Mechielsen, M. J., and van der Molen, H. J., FEBS Letters 26: 301, 1972.CrossRefGoogle Scholar
  18. 18.
    van Buerden-Lamers, W. M.O., Brinkmann, A. O., Mulder, E., and van der Molen, H. J., Biochem. J., in pressGoogle Scholar
  19. 19.
    van der Molen, H. J., This volume, p. 333.Google Scholar
  20. 20.
    Dym, M. and Fawcett, D. W., Biol. Reprod. 3: 308, 1970.PubMedGoogle Scholar
  21. 21.
    Setchell, B. P. In: The Testis. Edited by Johnson, A. D., Gomes, W. R. and Van Demark, N. L., Vol. I, Academic Press, New York, N. Y., 1970, p. 101.Google Scholar
  22. 22.
    Setchell, B. P., and Waites, G.M.H., J. Reprod. Fertil. Suppl. 13: 15, 1971.PubMedGoogle Scholar
  23. 23.
    Dorrington, J. H., and Fritz, I. B. In: Chemistry, Biologyand Immunology of Gonadotropins. Edited by Moudgal, N. R., Ademic Press, New York, N. Y., in press.Google Scholar
  24. 24.
    Dorrington, J. H., Roller, N., and Fritz, I. B., This volume, p. 231.Google Scholar
  25. 25.
    Means, A. R., and Hall, P. F., Biochemistry 8: 4293, 1969.PubMedCrossRefGoogle Scholar
  26. 26.
    Steinberger, E., Physiol. Revs. 51: 1, 1971.Google Scholar
  27. 27.
    Ericsson, R. J., Exper. Biol. Med. 137: 532, 1971.Google Scholar
  28. 28.
    Dorrington, J. H., and Fritz, I. B., Biochem. Biophys. Res. Commun. 54: 1425, 1973.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Irving B. Fritz
    • 1
  • Bozena Kopec
    • 1
  • Kam Lam
    • 1
  • Richard G. Vernon
    • 1
  1. 1.Banting and Best Department of Medical ResearchUniversity of TorontoTorontoCanada

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