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FSH Stimulation of Testicular Androgen Binding Protein (ABP)

Androgen “priming” increases the response to FSH
  • Vidar Hansson
  • Frank S. French
  • Samuel C. Weddington
  • Shihadeh N. Nayfeh
  • E. Martin Ritzen
Part of the Current Topics in Molecular Endocrinology book series (CTME, volume 1)

Abstract

Testicular androgen binding protein (ABP) is produced by the testis (1–3), presumably by the Sertoli cells, secreted into the testicular fluid and carried to the epididymis by way of the efferent ducts. ABP is completely dependent on FSH stimulation; it disappears rapidly after hypophysectomy and is dramatically stimulated by FSH (4), but not by LH or androgen alone. In the hypophysectomized rat, the accumulation of ABP in response to FSH is greatly enhanced by treatment with androgen.

Keywords

Sertoli Cell Seminiferous Tubule Efferent Duct Peritubular Capillary Testosterone Propionate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    French, F. S., and Ritzen, E. M., J. Reprod. Fert. 32: 479, 1973.CrossRefGoogle Scholar
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    French, F. S., and Ritzen, E. M., Endocrinology 93: 88, 1973.PubMedCrossRefGoogle Scholar
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    Hansson, V., Djoseland, O., Reusch, E., Attramadal, A., and Torgersen, O., Steroids 21: 457, 1973.Google Scholar
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    Hansson, V., Reusch, E., Trygstad, O., Torgersen, O., French, F. S., and Ritzen, E. M, Nature New Biol. 246: 56, 1973.PubMedGoogle Scholar
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    Tsuhima, T., Posner, B. and Friesen, H., Presented at the Human Growth Hormone Symposium, Baltimore, Oct. 9–12, 197 3.Google Scholar
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    Hans son, V., McLean, W. S., Smith, A. A., Tindall, D. J., Nayfeh, S. N., French, F. S., and Ritzen, E. M., IRCS Medical Science (73–11) 3–10–74.Google Scholar
  7. 7.
    Ritzen, E. M., French, F. S., Weddington, S. C., Nayfeh, S. N., and Hansson, V., This volume, p. 279. (see description of method).Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Vidar Hansson
    • 1
  • Frank S. French
    • 2
  • Samuel C. Weddington
    • 2
  • Shihadeh N. Nayfeh
    • 2
  • E. Martin Ritzen
    • 3
  1. 1.Institute for PathologyRikshospitaletOsloNorway
  2. 2.Depts. of Pediatrics, Biochemistry and The Laboratories for Reproductive BiologySchool of Medicine, University of North Carolina at Chapel HillUSA
  3. 3.Pediatric Endocrinology Unit, Clinical Research LabKarolinska sjukhusetStockholmSweden

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