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Hormone Binding and Target Cell Activation in the Testis pp 287–290Cite as

FSH Stimulation of Testicular Androgen Binding Protein (ABP)

Androgen “priming” increases the response to FSH

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Part of the book series: Current Topics in Molecular Endocrinology ((CTME,volume 1))

Abstract

Testicular androgen binding protein (ABP) is produced by the testis (1–3), presumably by the Sertoli cells, secreted into the testicular fluid and carried to the epididymis by way of the efferent ducts. ABP is completely dependent on FSH stimulation; it disappears rapidly after hypophysectomy and is dramatically stimulated by FSH (4), but not by LH or androgen alone. In the hypophysectomized rat, the accumulation of ABP in response to FSH is greatly enhanced by treatment with androgen.

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References

  1. French, F. S., and Ritzen, E. M., J. Reprod. Fert. 32: 479, 1973.

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Author information

Authors and Affiliations

  1. Institute for Pathology, Rikshospitalet, Oslo, Norway

    Vidar Hansson

  2. Depts. of Pediatrics, Biochemistry and The Laboratories for Reproductive Biology, School of Medicine, University of North Carolina at Chapel Hill, 27514, USA

    Frank S. French, Samuel C. Weddington & Shihadeh N. Nayfeh

  3. Pediatric Endocrinology Unit, Clinical Research Lab, Karolinska sjukhuset, Stockholm, Sweden

    E. Martin Ritzen

Authors
  1. Vidar Hansson
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  2. Frank S. French
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  3. Samuel C. Weddington
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  4. Shihadeh N. Nayfeh
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  5. E. Martin Ritzen
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Editor information

Editors and Affiliations

  1. Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

    Maria L. Dufau

  2. Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA

    Anthony R. Means

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© 1974 Plenum Press, New York

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Hansson, V., French, F.S., Weddington, S.C., Nayfeh, S.N., Ritzen, E.M. (1974). FSH Stimulation of Testicular Androgen Binding Protein (ABP). In: Dufau, M.L., Means, A.R. (eds) Hormone Binding and Target Cell Activation in the Testis. Current Topics in Molecular Endocrinology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2595-6_17

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  • DOI: https://doi.org/10.1007/978-1-4684-2595-6_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2597-0

  • Online ISBN: 978-1-4684-2595-6

  • eBook Packages: Springer Book Archive

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