Androgen Transport and Receptor Mechanisms in Testis and Epididymis

  • F. S. French
  • W. S. McLean
  • A. A. Smith
  • D. J. Tindall
  • S. C. Weddington
  • P. Petrusz
  • M. Sar
  • W. E. Stumpf
  • S. N. Nayfeh
  • V. Hansson
  • O. Trygstad
  • E. M. Ritzén
Part of the Current Topics in Molecular Endocrinology book series (CTME, volume 1)

Abstract

Spermatogenesis is an androgen dependent process which can be maintained in hypophysectomized rats by the administration of either testosterone (1) or 5α-dihydrostestosterone (2). Gonadotrophins may exert their effects on spermatogenesis indirectly by way of androgens. The sole action of LH appears to result from the stimulation of testosterone synthesis by the interstitial cells of Leydig. FSH is necessary for the full maintenance of spermatogenesis, but its effects can be mimicked by androgen and blocked by the anti-androgen, cyproterone, indicating that its action is linked in series with androgen (1) or that androgen is the mediator of FSH action.

Keywords

Androgen Receptor Sertoli Cell Seminiferous Tubule Testosterone Propionate Germinal Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Steinberger, E., Steinberger, A., and Ficher, M., Rec. Prog. Horm. Res. 26: 547, 1970.PubMedGoogle Scholar
  2. 2.
    Ahmad, N., Haltmeyer, G. C., and Eik-Nes, K., Biol. Reprod. 8: 411, 1973.PubMedGoogle Scholar
  3. 3.
    Blaquier, J. A., Cameo, M. S., and Burgos, M. H. Endocrinology 90: 839, 1972.CrossRefGoogle Scholar
  4. 4.
    Dyson, A. L. M. B., and Orgebin-Crist, M. C., Endocrinology 93: 391, 1973.PubMedCrossRefGoogle Scholar
  5. 5.
    Ritzén, E. M., Dobbins, M. C., French, F. S., and Nayfeh, S. N., Excerpta Medica Int. Congress Series, No. 256: 79, 1972, Abstract 200.Google Scholar
  6. 6.
    Hansson, V., Steroids 20, 575, 1972.PubMedCrossRefGoogle Scholar
  7. 7.
    Hansson, V., Djoseland, O., Reusch, E., Attramadal, A., and Torgersen, O., Steroids 21: 457, 1973.Google Scholar
  8. 8.
    Ritzén, E. M., Dobbins, M. C., Tindall, D. J., French, F. S., and. Nayfeh, S. N., Steroids 21: 593, 1973.PubMedCrossRefGoogle Scholar
  9. 9.
    French, F. S., and Ritzen, E. M., Endocrinology 93: 88, 1973.PubMedCrossRefGoogle Scholar
  10. 10.
    French, F. S., and Ritzen, E. M., J. Reprod. Fertil. 32: 479, 1973.PubMedCrossRefGoogle Scholar
  11. 11.
    Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem. 193: 265, 1951.PubMedGoogle Scholar
  12. 11.
    Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem. 193: 265, 1951.PubMedGoogle Scholar
  13. 13.
    Tuck, R. R., Stechell, B. P., G. M. H., and Young, J. A., Pfltigers Arch. ges. Physiol. 318: 225, 1970.CrossRefGoogle Scholar
  14. 14.
    Crabo, F., Acta Vet. Scand. 6, suppl. 5, 1965.Google Scholar
  15. 15.
    Stumpf, W. E., J. Histochem. Cytochem. 18: 21, 1970.PubMedCrossRefGoogle Scholar
  16. 16.
    Aafjes, J. H., and Vreeburg, T. M., J. Endocr. 53: 85, 1972.PubMedCrossRefGoogle Scholar
  17. 17.
    Hansson, V., Reusch, E., Ritzen, E. M., French, F. S., Trygstad, O., and Torgersen, O., Nature New Biology 246: 56, 1973.PubMedGoogle Scholar
  18. 18.
    Swerdloff, R. S., Walsh, P. C., Jacobs, H. S., and Odell, W. D., Endocrinology 88: 120, 1971.PubMedCrossRefGoogle Scholar
  19. 19.
    Roos, P., Thesis: “Human Follicle Stimulating Hormone” ( Almquist and Wiksells, Uppsala, 1967 ).Google Scholar
  20. 20.
    Steelman, S. L., and Pohley, F. M., Endocrinology 53: 604, 1953.PubMedCrossRefGoogle Scholar
  21. 21.
    Van Hell, H., Matthysen, R., and Overbeek, G. A., Acta Endocrinol. (Kbh.) 47: 409, 1964.Google Scholar
  22. 22.
    Hansson, V., Ritzen, E. M., and French, F. S., Proceedings of the IX Acta Endocrinologica Congress, Oslo, June 1973.Google Scholar
  23. 23.
    Petrusz, P., Robyn, C., and Diczfalusy, E., Acta Endocr. (Kbh.) 63: 454, 1970.Google Scholar
  24. 24.
    Tindall, D. J., French, F. S., and Nayfeh, S. N., Biochem. Biophys. Res. Comm. 49: 1391, 1972.PubMedCrossRefGoogle Scholar
  25. 25.
    Djoseland, O., Hansson, V., and Haugen, H., Steroids 21: 773, 1973.PubMedCrossRefGoogle Scholar
  26. 26.
    Sar, M., Liao, S., Stumpf, W. E., Endocrinology 86: 1008 (1970).PubMedCrossRefGoogle Scholar
  27. 27.
    Tindall, D. J., Hansson, V., Sar, M., Stumpf, W. E., French, F. S., and Nayfeh, S. N., Endocrinology.Google Scholar
  28. 28.
    Hansson, V., Djoseland, O., Reusch, E., Attramadal, A., and Torgersen, O., Steroids 22: 19, 1973.PubMedCrossRefGoogle Scholar
  29. 28.
    Hansson, V., Djoseland, O., Reusch, E., Attramadal, A., and Torgersen, O., Steroids 22: 19, 1973.PubMedCrossRefGoogle Scholar
  30. 30.
    Blaquier, J. A., and Calandra, R. S., Endocrinology 93: 51, 1973.PubMedCrossRefGoogle Scholar
  31. 31.
    Fang, S., and Liao, S., J. Biol. Chem. 246: 16, 1971.PubMedGoogle Scholar
  32. 32.
    Rennie, P., and Bruchovsky, N., J. Biol. Chem. 248: 328, 1973.Google Scholar
  33. 33.
    Hansson, V., McLean, W. S., Smith, A. A., Tindall, D. J., Nayfeh, S. N., French, F. S., and Ritzen, E. M., IRCS Medical Science (73–11) 3–10–34, 1973.Google Scholar
  34. 34.
    Dorrington, J. H., and Fritz, I. B., Bioche.m. Biophys. Res. Comm. 54: 1425, 1973.PubMedCrossRefGoogle Scholar
  35. 35.
    Ewing, L., and Brown, B., Biology of Reproduction 9: 92, 1973.Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • F. S. French
    • 1
  • W. S. McLean
    • 1
  • A. A. Smith
    • 1
  • D. J. Tindall
    • 1
  • S. C. Weddington
    • 1
  • P. Petrusz
    • 1
  • M. Sar
    • 1
  • W. E. Stumpf
    • 1
  • S. N. Nayfeh
    • 1
  • V. Hansson
    • 2
  • O. Trygstad
    • 2
  • E. M. Ritzén
    • 3
  1. 1.Departments of Pediatrics, Biochemistry and The Laboratories for Reproductive BiologyUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Institutes of Pathology and Pediatric ResearchRikshospitaletOsloNorway
  3. 3.Pediatric Endocrinology Unit, Clinical Research LaboratoryKarolinska sjukhusetStockholmSweden

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