Gonadotropin Binding and Activation of the Interstitial Cells of the Testis

  • K. J. Catt
  • T. Tsuruhara
  • C. Mendelson
  • J-M. Ketelslegers
  • M. L. Dufau
Part of the Current Topics in Molecular Endocrinology book series (CTME, volume 1)


Tissue receptor sites with high affinity for luteinizing hormone (LH) and human chorionic gonadotropin (hCG) have been defined in the interstitial cells of the testis, and also in the normal and gonadotropin-luteinized rat ovary (1–8). Comparable binding sites have also been demonstrated in the bovine corpus luteum, and in porcine granulosa cells during maturation in vivo and in vitro (9). The common receptor site for LH and hCG in these tissues is highly specific, with binding affinity only for molecules with the conformation characteristics of LH and chorionic gonadotropin. The biological specificity of hormone binding is demonstrable with LH from a wide variety of species, and with the placental gonadotropins of man, primates and the horse (2). The properties of the testis LH/hCG receptors, and their applications to radioligand-receptor assay, have been previously described in detail (2). In this chapter, the characteristics and application of gonadotropin receptors will be briefly reviewed, and more recent studies on the analysis of hormone-receptor interactions and the target cell responses to gonadotropins will be described.


Luteinizing Hormone Leydig Cell Testosterone Synthesis Gonadotropin Receptor Testicular Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Catt, K. J., Dufau, M. L. and Tsuruhara,. T., J. Clin. Endocr. 32: 860, 1971.PubMedCrossRefGoogle Scholar
  2. 2.
    Catt, K. J., Dufau, M. L. and Tsuruhara, T., J. Clin. Endocr. 34: 123, 1972.PubMedCrossRefGoogle Scholar
  3. 3.
    Catt, K. J., Tsuruhara, T. and Dufau, M. L., Biochim. Biophys. Acta 279: 194, 1972.PubMedCrossRefGoogle Scholar
  4. 4.
    Tsuruhara, T., Van Hall, E. V., Dufau, M. L., and Catt, K. J., Endocrinology 91: 463, 1972.PubMedCrossRefGoogle Scholar
  5. 5.
    Catt, K. J., and Dufau, M. L., Adv. Expt. Med. Biol. 36: 379, 1973.Google Scholar
  6. 6.
    Lee, C. Y., and Ryan, R. J., Endocrinology 89: 1515, 1971.PubMedCrossRefGoogle Scholar
  7. 7.
    Gospodarowicz, D., J. Biol. Chem. 248: 5042, 1973.PubMedGoogle Scholar
  8. 8.
    Danzo, B., Biochim. Biophys. Acta 304: 560, 1973.PubMedCrossRefGoogle Scholar
  9. 9.
    Channing, C. P. and Kammerman, S., Biol. Reprod. 10: 179, 1974.PubMedCrossRefGoogle Scholar
  10. 10.
    Dufau, M. L., Tsuruhara, T., and Catt, K. J., Biochim. Biophys. Acta 278: 281, 1972.PubMedGoogle Scholar
  11. 11.
    Dufau, M. L., Catt, K. J. and Tsuruhara, T., Proc. Nat. Acad. Sci. USA 69: 2414, 1972.PubMedCrossRefGoogle Scholar
  12. 12.
    Midgley, A. R., In International Congress on Gonadotropins, Bangalore, India, 1973 (in press).Google Scholar
  13. 13.
    Ketelslegers, J-M., Knott, G., and Catt, K. J., This volume, p. 31.Google Scholar
  14. 14.
    deKretser, D. M,., Catt, K. J., and Paulsen, C. A., Endocrinology 88: 332, 1971.CrossRefGoogle Scholar
  15. 15.
    Ashwell, G., and Morell, A. G., In Glycoproteins of Blood Cells and Plasma, Greenwalt, T. J. (ed.), Lippincott, Philadelphia, 1971, p. 173.Google Scholar
  16. 16.
    Dufau, M. L., Catt, K. J., and Tsuruhara, T., Biochim. Biophys. Acta 252: 574, 1971.PubMedCrossRefGoogle Scholar
  17. 17.
    Kono, T., and Barham, T. W., J. Biol. Chem. 246: 6210, 1971.PubMedGoogle Scholar
  18. 18.
    Cuatrecasas, P., J. Biol. Chem. 246: 6532, 1971.PubMedGoogle Scholar
  19. 19.
    Dufau, M. L., Catt, K. J., and Tsuruhara, T., Biochem. Biophys. Res. Comm. 44: 1022, 1971.PubMedCrossRefGoogle Scholar
  20. 20.
    Tsuruhara, T., Dufau, M. L., Hickman, J., and Catt, K. J., Endocrinology 91: 296, 1972.PubMedCrossRefGoogle Scholar
  21. 21.
    Catt, K. J., Dufau, M. L., and Tsuruhara, T., J. Clin. Endocr. 36: 73, 1973.PubMedCrossRefGoogle Scholar
  22. 22.
    Dufau, M. L., Charreau, E., and Catt, K. J., J. Biol. Chem. 248: 6973, 1973.PubMedGoogle Scholar
  23. 23.
    Dufau, M. L., Ryan, D. and Catt, K. J., Biochim. Biophys. Acta, in press.Google Scholar
  24. 24.
    Stephenson, R. P., Brit. J. Pharmacol. 11: 379, 1956.PubMedGoogle Scholar
  25. 25.
    Dufau, M. L., Watanabe, K., and Catt, K. J. Endocrinology 92: 6, 1973.CrossRefGoogle Scholar
  26. 26.
    Dufau, M. L., Catt, K. J., Tsuruhara, T., Endocrinology 90: 1032, 1972.PubMedCrossRefGoogle Scholar
  27. 27.
    Catt, K. J., Watanabe, K., and Dufau, M. L., Nature 239: 280, 1972.PubMedCrossRefGoogle Scholar
  28. 28.
    Catt, K. J, and Dufau, M. L., Nature New Biol. 242: 246, 1973.PubMedGoogle Scholar
  29. 29.
    Eggena, P., Schwartz, I. L. and Walter, W., J. General Physiol. 56: 250, 1971.CrossRefGoogle Scholar
  30. 30.
    Beall, R. J. and Sayers, G., Arch. Biochem. Biophys. 148: 70, 1972.PubMedCrossRefGoogle Scholar
  31. 31.
    Garren, L. D., Gill, G. N., Masui, H., and Walton, G. M., Recent Progr. Hormone Res. 27: 433, 1971.PubMedGoogle Scholar
  32. 32.
    Dufau, M. L., Mendelson, C. and Catt, K. J., J. Clin. Endocr. Metab., in press.Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • K. J. Catt
    • 1
  • T. Tsuruhara
    • 1
  • C. Mendelson
    • 1
  • J-M. Ketelslegers
    • 1
  • M. L. Dufau
    • 1
  1. 1.Section on Hormonal Regulation Reproduction Research Branch National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaUSA

Personalised recommendations