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The Use of Microwaves for the Hyperthermic Treatment of Cancer: Advantages and Disadvantages

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Photochemical and Photobiological Reviews

Abstract

Currently there is a renewed interest in the use of hyperthermia as a treatment modality in the management of malignant disease. This interest is based on old, anecdotal data, as well as on recent quantitative investigations (reviews: Dietzel, 1975; Thrall et al., 1976; Har-Kedar and Bleehen, 1976; Bronk, 1976; Gerner et al., 1975). The mode of cell killing by hyperthermia is not well understood. Thermodynamic considerations suggest that protein molecules are at risk, and some authors have focused on chromosomal proteins (review: Dewey, 1977). Other evidence implicates RNA synthesis (Mondovi et al., 1969) or membranes (Bowler et al., 1973; Hahn et al., 1975). Survival curves of mammalian cells exposed to elevated (> 42°C) temperatures for variable lengths of time resemble curves for cells exposed to ionizing radiations, i.e., a shoulder at short exposure times followed then by an exponential part at longer exposure times.

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Authors and Affiliations

  1. Department of Radiology, Stanford University School of Medicine, Stanford, California, 94305, USA

    George M. Hahn

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  1. George M. Hahn
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  1. Stanford University School of Medicine, USA

    Kendric C. Smith

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© 1978 Plenum Press, New York

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Hahn, G.M. (1978). The Use of Microwaves for the Hyperthermic Treatment of Cancer: Advantages and Disadvantages. In: Smith, K.C. (eds) Photochemical and Photobiological Reviews. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2580-2_7

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  • DOI: https://doi.org/10.1007/978-1-4684-2580-2_7

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