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Photochemical and Photobiological Reviews pp 135–162Cite as

The Role of Mutagenesis in Carcinogenesis

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Abstract

Although mutagenesis is recognized by scientists as a fundamental biological process, there are many who do not believe it plays any role in the genesis of several major diseases, such as cancer, atherosclerosis, teratological or congenital defects, and aging. If one accepts (1) the concept of “disease” as the manifestation of disruptions of biological, biochemical, or biophysical processes controlled by genetic products interacting with environmental factors (Brody, 1973), and (2) the concept of cancer as a phenotype (Lynch and Kaplan, 1974; Trosko and Chu, 1975), then it should be apparent that, conceptually, mutations (as well as gene modulations and enzyme inhibitors or stimulators) ought to be important causes of diseases. To demonstrate at the molecular level that either a particular DNA molecule or its product which controls cell division has been altered via mutagenesis in cancer cells is still a difficult technical task, if for no other reason than the fact that the genes and proteins involved in normal cell division have not yet been delineated (Trosko et al., 1977a).

Nothing in biology makes sense except in the light of evolution.

—T. Dobzhansky

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Authors and Affiliations

  1. Department of Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan, 48824, USA

    James E. Trosko & Chia-cheng Chang

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  1. James E. Trosko
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  2. Chia-cheng Chang
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  1. Stanford University School of Medicine, USA

    Kendric C. Smith

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© 1978 Plenum Press, New York

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Trosko, J.E., Chang, Cc. (1978). The Role of Mutagenesis in Carcinogenesis. In: Smith, K.C. (eds) Photochemical and Photobiological Reviews. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2580-2_4

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  • DOI: https://doi.org/10.1007/978-1-4684-2580-2_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2582-6

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