DNA Repair Enzymes in Mammalian Cells

  • Errol C. Friedberg
  • Kern H. Cook
  • James Duncan
  • Kristien Mortelmans


In the past two decades, considerable strides have been made in understanding the phenomenon of DNA damage and its repair at all levels of biological organization. Studies on living cells using prokaryote models have been extensively reviewed by a number of authors (Town et al., 1973; Setlow and Setlow, 1972; Smith, 1971; Witkin, 1969; Hanawalt, 1968; Howard-Flanders, 1968; Strauss, 1968). In recent years, considerable emphasis has been placed on DNA repair in mammalian systems, and this area of investigation too has been the subject of a number of review articles (Cleaver and Bootsma, 1975; Cleaver, 1974a; Strauss, 1974; Painter, 1970). Closely paralleling these biological studies, there have been significant efforts made to identify, purify, and characterize the numerous enzymatic and nonenzymatic components involved in the molecular mechanisms of DNA repair. These efforts have enjoyed particular success in prokaryote models such as Micrococcus luteus, Escherichia coli, and phage T4-infected E. coli (for recent reviews, see Grossman et al., 1975; Grossman, 1974). The present chapter addresses itself to a review of mammalian cell enzymes that may be significant in DNA repair. Where appropriate, we have discussed aspects of prokaryote enzymology that have not received much attention in the literature, and that are, or may be, directly relevant to mammalian repair systems.


Excision Repair Ataxia Telangiectasia Xeroderma Pigmentosum Endonuclease Activity Pyrimidine Dimer 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Errol C. Friedberg
    • 1
  • Kern H. Cook
    • 1
  • James Duncan
    • 1
  • Kristien Mortelmans
    • 1
  1. 1.Laboratory of Experimental Oncology, Department of PathologyStanford University School of MedicineStanfordUSA

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