Abstract
Ultraviolet (UV) radiation* of wavelengths longer than 295 nm from sunlight is a ubiquitous part of the natural environment of most organisms. Although beneficial and possibly beneficial aspects of sunlight have long been recognized and studied (Daniels, 1974; Wurtman, 1975), harmful effects, except for sunburn, have received relatively little attention until recently. Photochemical possibilities of natural components of the cell suggest that efficient mechanisms for the partial prevention or repair of resultant damage from exposure to solar radiation must exist for biological entities to survive regular exposure to natural sunlight. Recent work has identified DNA lesions induced by near-UV radiation (Section 2.4). Furthermore, mechanisms of protection and repair of near-UV-induced lesions have been reported (Sections 2.3 and 2.6).
Research supported by the U.S. Energy Research and Development Administration.
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References
Alper, T., 1963, Effects on irradiated micro-organisms of growth in the presence of acriflavine, Nature (London) 200:534–536.
Alper, T., and Hodgkins, B., 1969, “Excision repair” and dose-modification: Questions raised by radiobiological experiments with acriflavine, Mutat. Res. 8:15–23.
Alper, T., Forage, A. J., and Hodgkins, B., 1972, Protection of normal, lysogenic and pyocinogenic strains against ultraviolet radiation by bound acriflavine, J. Bacteriol. 110:823–830.
Ananthaswamy, H. N., and Eisenstark, A., 1976, Near-UV-induced breaks in phage UNA sensitization by hydrogen peroxide (a tryptophan photoproduct), Photochem. Photobiol. 24:439–442.
Ananthaswamy, H. N., and Eisenstark, A., 1977, Repair of hydrogen peroxide-induced single-strand breaks in Escherichia coli DNA, J. Bacteriol. 130:187–191.
Anderson, T. F., 1948, The growth of T2 virus on ultra-violet killed host cells, J. Bacteriol. 56:403–410.
Ashwood-Smith, M. J., Copeland, J., and Wilcockson, J., 1967, Sunlight and frozen bacteria, Nature (London) 214:33–35.
Baptist, J. E., and Haynes, R. H., 1972, The UV-X-ray synergism in E. coli. I. Inhibition by the incorporation of 5-bromouracil and by purine starvation, Photochem. Photobiol. 16:459–464.
Barran, L. R., Dooust, J. Y., Labelle, J. L., Martin, W. C., and Schneider, H., 1974, Differential effects of visible light on active transport in E. coli, Biochem. Biophys. Res. Commun. 56:522–528.
Beukers, R., and Berends, W., 1960, Isolation and identification of the irradiation product of thymine, Biochim. Biophys. Acta 41:550–551.
Birdsell, D. C., Bannon, P. J., and Webb, R. B., 1977, Harmful effects of near-ultraviolet radiation (365 nm) used for polymerizing a sealant and a composite resin, J. Am. Dent. Assoc. 94:311–314.
Blanc, P. L., Tuveson, R. W., and Sargent, M. L., 1976, Inactivation of carotenoid-producing and albino strains of Neurospora crassa by visible light, blacklight, and ultraviolet radiation, J. Bacteriol. 125:616–625.
Blum, H. F., 1941, Photodynamic Action and Diseases Caused by Light, Reinhold Publishing Co., New York.
Blum, H. F., 1943, Wavelength dependence of tumor induction by ultraviolet radiation, J. Natl. Cancer Inst. 3:533–537.
Blum, H. F., 1959, Carcinogenesis by Ultraviolet Light, Princeton University Press, Princeton, New Jersey.
Bodmer, W. F., and Ganeson, A. T., 1964, Biochemical and genetic studies of integration and recombination in Bacillus subtilis transformation, Genetics 50:717–738.
Boyce, R., and Setlow, R., 1963, The action spectra for ultraviolet-light inactivation of systems containing 5-bromouracil-substituted deoxyribonucleic acid, Biochim. Biophys. Acta 68:446–454.
Bragg, P. D., 1971, Effect of near-ultraviolet light on the respiratory chain of Escherichia coli, Can. J. Biochem. 49:492–495.
Brent, T. P., 1972, Repair enzymes suggested by mammalian endonuclease activity specific for ultraviolet-irradiated DNA, Nature (London) New Biol. 239:172–173.
Bresler, S. E., Kalinin, V. L., and Perumov, D. A., 1964, Theory of inactivation and reactivation of transforming DNA, Biopolymers 2:135–146.
Bresler, S. E., Kalinin, V. L., and Perumov, D. A., 1967, Inactivation and mutagenesis of DNA. I. Theory of inactivation of transforming DNA, Mutat. Res. 4:389–398.
Brown, M. S., 1977, Biological evidence for the destruction of the photoreactivation enzyme by 365 nm radiation Mutant. Res. (submitted).
Brown, M. S., and Webb, R. B., 1972, Photoreactivation of 365 nm inactivation of Escherichia coli, Mutat. Res. 15:348–352.
Brown, M. S., and Webb, R. B., 1977, Comparison of photoreactivation after inactivation of E. coli K12 AB2480 by 254 and 365 nm radiations (in preparation).
Bruce, A. K., 1958, Response of potassium retentivity and survival of yeast to far ultraviolet, near ultraviolet, visible, and X-radiation, J. Gen. Physiol. 41:693–702.
Buchbinder, L., Solomey, M., and Phelps, E. B., 1941, Studies on microorganisms in simulated room environments. III. The survival rates of streptococci in the presence of natural daylight and sunlight, and artificial illumination, J. Bacteriol. 42:353–366.
Burchard, R. P., and Dworkin, M., 1966, Light-induced lysis and carotenogenesis in Myxococcus xanthus, J. Bacteriol. 91:535–545.
Burchard, R. P., Gordon, S. A., and Dworkin, M., 1966, Action spectrum for the photolysis of Myxococcus xanthus, J. Bacteriol. 91:896–897.
Cabrera-Juarez, E., 1964, “Black light” inactivation of transforming deoxyribonucleic acid from Haemophilus influenzae, J. Bacteriol. 87:771–778.
Cabrera-Juarez, E., and Espinosa-Lara, M., 1974, Lethal and mutagenic action of black light (325-400 nm) on Haemophilus influenzae in the presence of air, J. Bacteriol. 117:960–964.
Cabrera-Juarez, E., and Swenson, P. A., 1975, Action spectrum for the oxygen independent inactivation of Haemophilus influenzae transforming DNA with near-UV light, Photochem. Photobiol. 21:193–196.
Cabrera-Juarez, E., Setlow, J. K., Swenson, P. A., and Peak, M. J., 1976, Oxygen-independent inactivation of Haemophilus influenzae transforming DNA by monochromatic radiation: Action spectrum, effect of histidine and repair, Photochem. Photobiol. 23:309–314.
Caldwell, M. M., 1971, Solar UV irradiation and growth and development of higher plants, in: Photophysiology, Vol. 6 (A. C. Giese, ed.), pp. 131–177, Academic Press, New York.
Claes, H., 1960, Interaction between chlorophyll and carotenes with different chromophoric groups, Biochem. Biophys. Res. Commun. 3:585–590.
Claes, H., 1961, Energieiibertrangung non angeretem Chlorophyll auf C40-Polyene mit verschiedenen Chromophoren Gruppen, Naturforsch. Teil 16B:445–454.
Codd, G. A., 1972, The photoinhibition of malate dehydrogenase, FEBS Lett. 20:211–214.
Coetzee, W. F., and Pollard, E. C., 1974, Near-UV effects on the induction of prophage, Radiat. Res. 57:319–331.
Coetzee, W. F., and Pollard, E. C., 1975, Near ultraviolet inactivation studies on Escherichia coli tryptophanase and tryptophan synthetase, Photochem. Photobiol. 22:29–32.
Cole, R. S., and Sinden, R. R., 1975, Psoralen cross-links in DNA: Biological consequences and cellular repair, in: Radiation Research: Biochemical, Chemical, and Physical Perspectives (O. F. Nygaard, H. I. Adler, and W. K. Sinclair, eds.), pp. 582–589, Academic Press, New York.
Council on Dental Materials and Devices, 1976, Guidelines on the use of ultraviolet radiation in dentistry, Reports of Councils and Bureaus, J. Am. Dent. Assoc. 92:775–776.
Crounse, J. B., Feldman, R. P., and Clayton, R. K., 1963, Accumulation of polyene precursors of neurosporene in mutant strains of Rhodopseudomonas spheroides, Nature (London) 198:1227–1228.
Cutchis, P., 1974, Stratospheric ozone depletion and solar ultraviolet radiation on earth, Science 184:13–19.
Daniels, F., 1964, Sun exposure and skin aging, N. Y. State J. Med. 64:2066–2069.
Daniels, F., 1974, Physiological and pathological extracutaneous effects of light on man and mammals, not mediated by pineal or other neuroendocrine mechanisms, in: Sunlight and Man (T. B. Fitzpatrick, M. A. Pathak, L. C. Harber, M. Seiji, and A. Kukita, eds.), pp. 247–258, University of Tokyo Press, Tokyo.
Danpure, H. J., and Tyrrell, R. M., 1975, The action of near UV (365 nm) radiation on two mammalian cell lines irradiated in inorganic buffer, Abst. Am. Soc. Photobiol., pp. 93-94.
Danpure, H. J., and Tyrrell, R. M., 1976, Oxygen-dependence of near UV (365 nm) lethality and the interaction of near UV and X-rays in two mammalian cell lines, Photochem. Photobiol. 23:171–177.
Davidoff-Abelson and Dubnau, D., 1973, Conditions affecting the isolation from transformed cells of Bacillus subtilis of high-molecular-weight single-stranded deoxyribonucleic acid of donor origin, J. Bacteriol. 116:146–153.
Davies, D. R., Arlett, C. F., Munson, R. J., and Bridges, B. A., 1967, Interaction between ultraviolet light and γ-radiation damage in the induction of mutants of Escherichia coli: The response in strains with normal and reduced ability to repair ultraviolet damage, J. Gen. Microbiol. 46:329–338.
Day, R. S., and Deering, R. A., 1968, Recovery of colony-forming ability and genetic marker activity by UV-damaged Hemophilus influenzae, Biophys. J. 8:1119–1130.
Day, R. S., and Muel, B., 1974, Ultraviolet inactivation of the ability of E. coli to support the growth of phage T7: An action spectrum, Photochem. Photobiol. 20:95–102.
Deering, R. A., and Setlow, R. B., 1963, Effects of ultraviolet light on thymidine dinucleotide and polynucleotide, Biochim. Biophys. Acta 63:526–534.
Denniston, K. J., Webb, R. B., and Brown, M. S., 1972, Action spectrum for carotenoid protection against lethal photo-oxiaation of Sarcina lutea, Abst. Am. Soc. Microbiol., p. 184.
Doyle, R. J., and Kubitschek, H. E., 1976, Near ultraviolet light inactivation of an energy-independent membrane transport system in Saccharomyces cerevisiae, Photochem. Photobiol, 24:291–293.
Dubnau, D., and Cirigliano, C, 1972, Fate of transforming DNA following uptake by competent Bacillus subtilis. III. Formation and properties of products isolated from transformed cells which are derived entirely from donor DNA, J. Mol. Biol. 64:9–29.
Duggar, B. M., 1936, Effects of radiation on bacteria, in: Biological Effects of Radiation (B. M. Duggar, ed.), pp. 1119–1149, McGraw-Hill Book Co., New York.
Dulbecco, R., and Weigle, J. J., 1952, Inhibition of bacteriophage development in bacteria illuminated with visible light, Experientia 8:386–389.
Durham, N. M., and Wyss, O., 1956, An example of non-inherited radiation resistance, J. Bacteriol. 72:95–100.
Dworkin, M., 1958, Endogenous photosensitization in a carotenoidless mutant of Rhodopseudomonas speroides, J. Gen. Physiol. 41:1099–1112.
Eisenstark, A., 1970, Sensitivity of Salmonella typhimurium recombinationless (rec) mutants to visible and near-visible light, Mutat. Res. 10:1–6.
Eisenstark, A., 1971, Mutagenic and lethal effects of visible and near-ultraviolet light on bacterial cells, in: Advances in Genetics, Vol. 12 (E. W. Caspari, ed.), pp. 167–198, Academic Press, New York.
Eisenstark, A., 1973, Tryptophan photoproduct as a genetic probe: Effects on bacteria, in: Fifth Stadler Genetics Symposium (G. Kimber and G. P. R. Redei, eds.), pp. 49–60, University of Missouri, Columbia.
Eisenstark, A., and Ruff, D., 1970, Repair in phage and bacteria inactivated by light from fluorescent and photo lamps, Biochem. Biophys. Res. Commun. 38:244–248.
Elkind, M. M., and Sutton, H., 1957a, Lethal effect of visible light on a mutant strain of haploid yeast. I. General dependencies, Arch. Biochem. Biophys. 72:84–95.
Elkind, M. M., and Sutton, H., 1957b, Lethal effect of visible light on a mutant strain of haploid yeast. II. Absorption and action spectrum, Arch. Biochem. Biophys. 72:96–111.
Epstein, J. H., 1970, Ultraviolet carcinogenesis, in: Photophysiology, Vol. 5 (A. C. Giese, ed.), pp. 235–273, Academic Press, New York.
Epstein, J. H., 1974, Phototoxicity and photoallergy: Clinical syndromes, in: Sunlight and Man (T. B. Fitzpatrick, M. A. Pathak, L. C. Harber, M. Seiji, and A. Kukita, eds.), pp. 459–477, University of Tokyo Press, Tokyo.
Felber, T. D., Smith, E. B., Knox, J. M., Wallis, C., and Melnick, J. L., 1973, Photodynamic inactivation of herpes simplex, J. Am. Med. Assoc. 223:289–292.
Ferron, W. L., Eisenstark, A., and Mackay, D., 1972, Distinction between far-and near-ultraviolet light killing of recombinationless (recA) Salmonella typhimurium, Biochim. Biophys. Acta 277:651–658.
Fong, F., Peters, J., Pauling, C., and Heath, R. L., 1975, Two mechanisms of near-ultraviolet lethality in Saccharomyces cerevisiae. Respiratory capacity-dependent and an irreversible inactivation, Biochim. Biophys. Acta 387:451–460.
Foote, C. S., 1976, Photosensitized oxidation and singlet oxygen: Consequences in biological systems, in: Free Radicals in Biology Vol. 2 (W. A. Pryor, ed.), pp. 85–124, Academic Press, New York.
Foote, C. S., and Denny, R. W., 1968, Chemistry of singlet oxygen. VII. Quenching by β-carotene, J. Am. Chem. Soc. 90:6233–6235.
Foote, C. S., Chang, Y. C., and Denny, R. W., 1970, Chemistry of singlet oxygen. X. Carotenoid quenching parallels biological protection, J. Am. Chem. Soc. 92:5216–5218.
Forbes, P. D., 1973, Influence of long wave UV on photocarcinogenesis, Abst. Am. Soc. Photobiol., p. 136.
Forbes, P. D., Davies, R. E., D’Aloisio, L. C., and Cole, C., 1976, Emission spectrum differences in fluorescent blacklight lamps. Photochem. Photobiol. 23:613–615.
Freeman, R. G., 1975, Data on the action spectrum tor ultraviolet carcinogenesis, J. Natl. Cancer Inst. 55:1119–1121.
Freeman, R. G., Owens, D. W., and Knox, J. M., 1966, Relative energy requirements for an erythemal response of skin to monochromatic wavelengths of ultraviolet present in the solar spectrum, J. Invest. Dermatol. 47:586–592.
Freese, E. B., Gerson, J., Taber, H., Rhaese, H.-J., and Freese, E., 1967, Inactivating DNA alterations induced by peroxides and peroxide-producing agents, Mutat. Res. 4:517–531.
Fuks, Z. and Smith, K. C., 1971, Effect of quinacrine on X-ray sensitivity and repair of uamaged DNA in Escherichia coli K-12, Radiat. Res. 48:63–73.
Ganesan, A. K., and Smith, K. C., 1972, Requirement for protein synthesis in rec-dependent repair of deoxyribonucleic acid in Escherichia coli after ultraviolet or x irradiation, J. Bacteriol. 111:575–585.
Gates, F. L., 1930, A study of the bactericidal action of ultraviolet light. III. The absorption of ultraviolet light by bacteria, J. Gen. Physiol. 14:31–42.
Giese, A. C., 1946, An intracellular photodynamic sensitizer in Blepharisma, J. Cell. Comp. Physiol. 28:119–127.
Giese, A. C., 1953, Some properties of a phytodynamic pigment from Blepharisma, J. Gen. Physiol. 37:259–269.
Giese, A. C., 1968, Ultraviolet action spectra in perspective: With special reference to mutation, Photochem. Photobiol. 8:537–546.
Giese, A. C., 1971, Photosensitization by natural pigments, in: Photophysiology, Vol. 6 (A. C. Giese, ed.), pp. 77–129, Academic Press, New York.
Giese, A. C., 1976, Living with Our Sun’s Ultraviolet Rays, Plenum Press, New York.
Ginsberg, D. M., and Jagger, J., 1965, Evidence that initial ultraviolet lethal damage in Escherichia coli is independent of growth phase, J. Gen. Microbiol. 40:171–184.
Glatzer, L., 1977, Radioactive near-ultraviolet photoproducts of L-tryptophan solutions (in preparation).
Grover, D., and Zigman, S., 1972, Coloration of human lenses by near-UV photooxidized tryptophan, Exp. Eye Res. 13:70–76.
Grube, D. D., Ley, R. D., and Fry, R. J. M., 1977, Photosensitizing effects of 8-methoxypsoralen on the skin of hairless mice. II. Strain and spectral difference for tumorigenesis, Photochem. Photobiol. 25:271–278.
Hakim, R. E., Griffin, A. C., and Knox, J. M., 1960, Erythema and tumor formation in methoxsalen treated mice exposed to fluorescent light, Arch. Dermatol. 82:572–577.
Hanawalt, P. C., 1966, The UV sensitivity of bacteria: Its relationship to the replication cycle, Photochem. Photobiol. 5:1–12.
Harber, L. C., and Baer, R. L., 1972, Pathogenic mechanisms of drug-induced photo-sensitivity, J. Invest. Dermatol. 58:327–342.
Hariharan, P. V. and Cerutti, P. A., 1974, The incision and strand rejoining step in the excision repair of 5,6-dihydroxy-dihydrothymine by crude E. coli extracts, Biochem. Biophys. Res. Commun. 61:375–379.
Hariharan, P. V., and Cerutti, P. A., 1976, Excision of ultraviolet and gamma ray products of the 5,6-dihydroxydihydrothymine-type by nuclear preparations of xeroderma pigmentosum cells, Biochem. Biophys. Acta 477:375–378.
Hariharan, P. V., and Cerutti, P A., 1977, Formation of products of the 5,6-dihydroxy-dihydrothymine type by ultraviolet light in HeLa cells, Biochemistry 16:2791–2795.
Hariharan, P. V., Achey, P. M., and Cerutti, P. A., 1977, Biological effect of thymine ring-saturation in coliphage φX174-DNA, Radiat. Res. 69:375–378.
Harm, W., 1966, Repair effects in phage and bacteria exposed to sunlight, Radiat. Res. Suppl. 6:215–216.
Harm, W., 1967, Differential effects of acriflavine and caffeine on various ultraviolet-irradiated Escherichia coli strains and T1 phage, Mutat. Res. 4:93–110.
Harm, W., 1969, Biological determination of the germicidal activity of sunlight, Radiat. Res. 40:63–69.
Harrison, A. P., 1967, Survival of bacteria; harmful effects of light, with some comparisons with other adverse physical agents, Annu. Rev. Microbiol. 21:143–156.
Hausser, K. W., and Vahle, W., 1927, Sunburn and suntanning, Wiss. Veroeff. Siemens Konzern 6:101–120.
Haynes, R. H., 1964, Molecular localization of radiation damage relevant to bacterial inactivation, in: Physical Processes in Radiation Biology (L. Augenstein, R. Mason, and B. Rosenberg, eds.), pp. 51–72, Academic Press, New York.
Haynes, R. H., 1966, The interpretation of microbial inactivation and recovery phenomena, Radiat. Res. Suppl 6:1–29.
Haynes, R. H., 1975, The influence of repair processes on radiobiological survival curves, in: Cell Survival after Low Doses of Radiation: Theoretical and Clinical Implications (T. Alper, ed.), pp. 197–208, Wiley, New York.
Hill, R. F., 1956, Effects of illumination on plaque formation by Escherichia coli infected with T1 bacteriophage, J. Bacteriol. 71:231–235.
Hollaender, A., 1943, Effect of long ultraviolet and short visible radiation (3500-4900 Å) on Escherichia coli, J. Bacteriol. 46:531–541.
Hollaender, A., and Emmons, C. W., 1946, Induced mutations and speciation in fungi, Cold Spring Harbor Symp. Quant. Biol. 11:78–84.
Howard-Flanders, P., and Boyce, R. P., 1966, DNA repair and genetic recombination: Studies on mutants of Escherichia coli defective in these processes, Radiat. Res. Suppl. 6:156–184.
Hutchinson, F., and Hales, H. B., 1970, Mechanism of the sensitization of bacterial transforming DNA to ultraviolet light to the incorporation of 5-bromouracil, J. Mol. Biol. 50:59–69.
Igali, S., Bridges, B. A., Ashwood-Smith, M. J., and Scott, B. R., 1970, Mutagenesis in Escherichia coli. IV. Photosensitization to near ultraviolet light by 8-methoxypsoralen, Mutat. Res. 9:21–30.
Jagger, J., 1964, Photoprotection from far ultraviolet effects in cells, in: Advances in Chemical Physics, Vol. 7 (J. Duchesne, ed.), pp. 584–601, Interscience, New York.
Jagger, J., 1967, Introduction to Research in Ultraviolet Photobiology, Prentice-Hall, Englewood Cliffs, N.J.
Jagger, J., 1972, Growth delay and photoprotection induced by near-ultraviolet light, in: Research Progress in Organic, Biological and Medicinal Chemistry, Vol. 3 (U. Gallo and L. Santamaria, eds.), Part 1, pp. 383–401, American Elsevier, New York.
Jagger, J., 1973, Realm of the ultraviolet, Photochem. Photobiol. 18:353–354.
Jagger, J., 1975, Inhibition by sunlight of the growth of Escherichia coli B/r, Photochem. Photobiol. 22:67–70.
Jagger, J., and Stafford, R. S., 1962, Biological and physical ranges of photoprotection from ultraviolet damage in microorganisms. Photochem. Photobiol. 1:245–257.
Jagger, J., Wise, W. C., and Stafford, R. S., 1964, Delay in growth and division induced by near ultraviolet radiation in Escherichia coli B and its role in photoprotection and liquid holding recovery, Photochem. Photobiol. 3:11–24.
Jagger, J., Stafford, R. S., and Snow, J. M., 1969, Thymine-dimer and action-spectrum evidence for indirect photoreactivation in Escherichia coli, Photochem. Photobiol. 10:383–396.
Kaplan, R. W., 1956, Dose-effect curves of S-mutation and killing in Serratia marcescens, Arch. Microbiol. 24:60–79.
Kaplan, R. W., and Kaplan, C., 1956, Influence of water content on UV-induced S-mutation and killing in Serratia, Exp. Cell Res. 11:378–392.
Kashket, E. R., and Brodie, A. F., 1962, Effects of near-ultraviolet irradiation on growth and oxidative metabolism of bacteria. J. Bacteriol. 83:1094–1100.
Kelly, E. W., Jr., and Pinkus, H., 1955, Local application of 8-methoxypsoralen in vitiligo, J. Invest. Dermatol. 25:453–456.
Keiner, A., and Halle, S., 1960, Mutagenesis by visible light in a mutable strain of Escherichia coli, Bacteriol. Proc. p. 67.
Knowles, A., 1975, The effects of photodynamic action involving oxygen upon biological systems, in: Radiation Research: Biochemical, Chemical, and Physical Perspectives (O. F. Nygaard, H. I. Adler, and W. K. Sinclair, eds.), pp. 612–622, Academic Press, New York.
Koch, A. L., Doyle, R. J., and Kubitschek, H. E., 1976, Inactivation of membrane transport in Escherichia coli by black light, J. Bacteriol. 126:140–146.
Koller, L. R., 1939, Bactericidal effects of ultraviolet radiation produced by low pressure mercury vapour lamps, J. Appl. Phys. 10:621–630.
Krinsky, N. I., 1976, Cellular damage initiated by visible light, in: The Survival of Vegetative Microbes (T. R. G. Gray and J. R. Postgate, eds.), pp. 209–230, Cambridge University Press, Cambridge.
Kubitschek, H. E., 1967, Mutagenesis by near-visible light, Science 155:1545–1546.
Kubitschek, H. E., 1970, Introduction to Research with Continuous Cultures (A. Hollaender, ed.), Prentice-Hall, Englewood Cliffs, N.J.
Kubitschek, H. E., and Bendigkeit, H. E., 1964a, Mutation in continuous cultures. I. Dependence of mutational response upon growth limiting factors, Mutat. Res. 1:113–120.
Kubitschek, H. E., and Bendigkeit, H. E., 1964b, Mutation in continuous cultures. II. Mutations induced with ultraviolet and 2-aminopurine, Mutat. Res. 1:209–218.
Kubitschek, H. E., and Doyle, R. J., 1977, Near-UV induced inhibition of succinate transport in E. coli B/r (in preparation).
Kubitschek, H. E., Nance, S. L., and Doyle, R. J., 1975, Induction of growth delay by inactivation of membrane transport after exposure to near-UV, Abst. Am. Soc. Photobiol., p. 118.
Leff, J., and Krinsky, N. I., 1967, A mutagenic effect of visible light mediated by endogenous pigments in Euglena gracilis, Science 158:1332–1334.
Lerner, A. B., Denton, C. A., and Fitzpatrick, T. B., 1969, Clinical and experimental studies with 8-methoxypsoralen in vitiligo, Arch. Dermatol. 100:224–229.
Ley, R. D., Grube, D. D., and Fry, R. J. M., 1977, Photosensitizing effects of 8-methoxypsoralen on the skin of hairless mice. I. Formation of interstrand cross-links in epidermal DNA, Photochem. Photobiol. 25:265–270.
Lucey, J. F., Ferreiro, M., and Hewitt, J., 1968, Prevention of hyperbilirubinemia of prematurity by phototherapy, Pediatrics 41:1047–1056.
Luckiesh, M., 1946, Applications of Germicidal, Erythemal, and Infrared Energy, Van Nostrand, New York.
Luria, S. E., 1955, Radiation and viruses, in: Radiation Biology, Vol. 2 (A. Hollaender, ed.), pp. 333–364, McGraw-Hill, New York.
Mackay, D., Eisenstark, A., Webb, R. B., and Brown, M. S., 1976, Action spectra for lethality in recombinationless strains of Salmonella typhimurium and Escherichia coli, Photochem. Photobiol. 24:337–344.
Magnus, I. A., 1968, Photobiological aspects of porphyria, Proc. Roy. Soc. Med. 61:196–198.
Maguire, B. H., 1960, Lethal effect of visible light on cavernicolous astracods, Science 132:226–227.
Marmur, J., Anderson, W. F., Mathews, L., Berns, K., Gajewski, E., and Doty, P., 1961, The effects of ultraviolet light on the biological and physical chemical properties of deoxyribonucleic acids, J. Cell. Comp. Physiol. 58:33–55 (Suppl. 2).
Martignoni, K. D., and Smith, K. C., 1972, The synergistic interaction of UV and X-radiation in mutants of E. coli K12, Radiat. Res. 51:487–488.
Martignoni, K. D., and Smith, K. C., 1973, The synergistic action of ultraviolet and X-radiation on mutants of Escherichia coli K-12, Photochem. Photobiol. 18:1–8.
Mathews, M. M., 1964a, The effect of low temperature on the protection by carotenoids against photosensitization in Sarcina lutea, Photochem. Photobiol. 3:75–77.
Mathews, M. M., 1964b, Protective effect of β-carotene against lethal photosensitization by haematoporphyrin, Nature (London) 203:1092.
Mathews, M. M., and Krinsky, N. I., 1965, The relationship between carotenoid pigments and resistance to radiation in non-photosynthetic bacteria, Photochem. Photobiol. 4:813–817.
Mathews, M. M., and Sistrom, W. R., 1959a, Intracellular location of carotenoid pigments and some respiratory enzymes in Sarcina lutea, J. Bacteriol. 78:778–789.
Mathews, M. M., and Sistrom, W. R., 1959b, Function of carotenoid pigments in non-photosynthetic bacteria, Nature (London) 184:1892–1893.
Mathews, M. M., and Sistrom, W. R., 1960, The function of the carotenoid pigments of Sarcina lutea, Arch. Mikrobiol. 35:139–146.
Mathews-Roth, M., 1967, The photosensitizing ability of prodigiosin, Photochem. Photobiol. 6:923–926.
Mathews-Roth, M. M., and Krinsky, N. I., 1970, Studies on the protective function of the carotenoid pigments of Sarcina lutea, Photochem. Photobiol. 11:419–428.
Mathews-Roth, M. M., and Pathak, M. A., 1975, Phytoene as a protective agent against sunburn (280 nm) radiation in guinea pigs, Photochem. Photobiol. 21:261–263.
Mathews-Roth, M. M., Pathak, M. A., Fitzpatrick, T. B., Harber, L. C., and Kass, E. H., 1970, Beta-carotene as a photoprotective agent in erythropoietic protoporphyria, N. Engl. J. Med. 282:1231–1234.
Mathews-Roth, M. M., Wilson, T., Fujimori, E., and Krinsky, N. I., 1974a, Carotenoid chromophore length and protection against photosensitization, Photochem. Photobiol. 19:217–222.
Mathews-Roth, M. M., Pathak, M. A., Fitzpatrick, T. B., Harbor, L. C., and Kass, E. H., 1974b, Beta-carotene as an oral photoprotective agent in erythropoietic protoporphyria, in: Sunlight and Man (T. B. Fitzpatrick, M. A. Pathak, L. C. Harber, M. Seiji, and A. Kukita, eds.), pp. 659–668, University of Tokyo Press, Tokyo.
Mathews-Roth, M. M., Pathak, M. A., Fitzpatrick, T. B., Harber, L. C., and Kass, E. H., 1974c, β-Carotene as an oral photoprotective agent in erythropoietic protoporphyria. J. Am. Med. Assoc. 228:1004–1008.
McCormick, J. P., Fischer, J. R., Pochlatko, J. P., and Eisenstark, A., 1975, Characterization of a cell-lethal product from the photooxidation of tryptophan: Hydrogen peroxide, Science 191:468–469.
McGrath, R. A., and Williams, R. W., 1966, Reconstruction in vivo of irradiated Escherichia coli deoxyribonucleic acid; the rejoining of broken pieces, Nature (London) 212:534–535.
Moore, C., Wallis, C., Melnick, J. L., and Kuns, M. D., 1972, Photodynamic treatment of herpes keratitis, Inject. Immunol. 5:169–171.
Moroson, H., and Alexander, P., 1961, Changes produced by ultraviolet light in the presence and in the absence of oxygen on the physical chemical properties of deoxyribonucleic acid, Radiat. Res. 14:29–49.
Morton, R. A., and Haynes, R. B., 1969, Changes in the ultraviolet sensitivity of Escherichia coli during growth in batch cultures, J. Bacteriol. 97:1379–1385.
Musajo, L., and Rodighiero, G., 1972, Mode of photosensitizing action of furocoumarins, in: Photophysiology, Vol. 7 (A. C. Giese, ed), pp. 115–147, Academic Press, New York.
Notani, N., and Goodgal, S. H., 1966, On the nature of recombinants formed during transformation in Haemophilus influenzae, J. Gen. Physiol. 49:197–209.
Parrish, J. A., Ying, C. Y., Pathak, M. A., and Fitzpatrick, T. B., 1974, Erythemogenic properties of long-wave ultraviolet light, in: Sunlight and Man (T. B. Fitzpatrick, M. A. Pathak, L. G. Harber, M. Seiji, and A. Kukita, eds.), pp. 131–141, University of Tokyo Press, Tokyo.
Pathak, M. A., 1972, Biochemical changes in epidermal nucleic acids following UV irradiation, Abst. Int. Congr. Photobiol., p. 44.
Pathak, M. A., and Stratton, K., 1969, Effects of ultraviolet and visible radiation and production of free radicals in skin, in: The Biologic Effects of Ultraviolet Radiation (F. Urbach, ed.), pp. 207–222, Pergamon Press, New York.
Pathak, M. A., Riley, F. C., and Fitzpatrick, T. B., 1962, Melanogensis in human skin following exposure to long-wave ultraviolet light and visible light, J. Invest. Dermatol. 39:435–443.
Pathak, M. A., Kramer, D. M., and Fitzpatrick, T. B., 1975, Photobiology and photochemistry of furocoumarins (psoralens), in: Sunlight and Man (T. B. Fitzpatrick, M. A.
Pathak, L. C. Harber, M. Seiji, and A. Kukita, eds.), pp. 335–368, University of Tokyo Press, Tokyo.
Patrick, M., and Rupert, C. S., 1967, The effect of host-cell reactivation on assay of UV-irradiated Haemophilus influenza transforming DNA, Photochem. Photobiol. 6:1–20.
Peak, M. J., 1970, Some observations on the lethal effects of near-ultraviolet light on Escherichia coli, compared with the lethal effects of far-ultraviolet light, Photochem. Photobiol. 12:1–8.
Peak, M. J., and Peak, J. G., 1973, Protection by histidine against the inactivation of DNA transforming activity by near-ultraviolet light, Photochem. Photobiol. 18:525–527.
Peak, M. J., and Peak, J. G., 1974, Protection of transforming DNA against X-rays by histidine, glycerol, AET and the uvr - genotype, Radiat. Res. 59:288.
Peak, M. J., and Peak, J. G., 1975, Protection by AET against inactivation of transforming DNA by near-ultraviolet light, action spectrum. Photochem. Photobiol. 22:147–148.
Peak, M. J., Peak, J. G., and Webb, R. B., 1973a, Inactivation of transforming DNA by ultraviolet light. I. Near-UV action spectrum for marker inactivation, Mutat. Res. 20:129–135.
Peak, M. J., Peak, J. G., and Webb, R. B., 1973b, Inactivation of transforming DNA by ultraviolet light. II. Protection by histidine against near-UV irradiation: Action spectrum. Mutat. Res. 20:137–141.
Peak, M. J., Peak, J. G., and Webb, R. B., 1973c, Inactivation of transforming DNA by ultraviolet light. III. Further observations on the effects of 365 nm radiation, Mutat. Res. 20:143–148
Peak, M. J., Peak, J. G., and Webb, R. B., 1975, Synergism between different near-ultraviolet wavelengths in the inactivation of transforming DNA, Photochem. Photobiol. 21:129–131.
Piechowska, M., and Fox, M. S., 1971, Fate of transforming deoxyribonucleate in Bacillus subtilis, J. Bacteriol. 108:680–689.
Pollard, E. C., 1974, Cellular and molecular effects of solar ultraviolet radiation, Photochem. Photobiol. 20:301–308.
Rahn, R. O., 1973, Denaturation in ultraviolet-irradiated DNA, in: Photophysiology, Vol. 8 (A. C. Giese, ed.), pp. 231–255, Academic Press, New York.
Rahn, R. O., Landry, L. C., and Carrier, W. L., 1974, Formation of chain breaks and thymine dimers in DNA upon photosensitization at 313 nm with acetophenone, acetone, or benzophenone, Photochem. Photobiol. 19:75–78.
Ramabhadran, T. V., 1975, Effects of near-ultraviolet and violet radiations (313-405 nm) on DNA, RNA, and protein synthesis in E. coli B/r: Implications for growth delay, Photochem. Photobiol. 22:117–123.
Ramabhadran, T. V., and Jagger, J., 1975, Evidence against DNA as the target for 334 nm-induced growth delay in Escherichia coli, Photochem. Photobiol. 21:227–233.
Ramabhadran, T. V., and Jagger, J., 1976, Mechanism of growth delay induced in Escherichia coli by near ultraviolet radiation, Proc. Natl. Acad. Sci. USA 73:59–63.
Ramabhadran, T. V., Fossum, T., and Jagger, J., 1976, In vivo induction of 4-thiouridine-cytidine adducts in tRNA of E. coli B/r by near-ultraviolet radiation, Photochem. Photobiol. 23:315–321.
Randolph, M. L., and Setlow, J. K., 1971, Mechanism of inactivation of transforming deoxyribonucleic acid by X rays, J. Bacteriol. 106:221–226.
Rapp, F., Lui-Lien, H. L., and Jerkofsky, M., 1973, Transformation of mammalian cells by DNA containing viruses following photodynamic inactivation, Virology 55:339–346.
Resnick, M. A., 1970, Sunlight-induced killing in Saccharomyces cerevisiae, Nature (London) 226:377–378.
Ritchie, D. A., 1964, Mutagenesis with light and proflavine in phage T4, Genet. Res. Camb. 5:168–169.
Robb, F. T., Hauman, J. H., and Peak, M. J., 1977, Similar spectra for the inactivation by monochromatic light of two distinct leucine transport systems in Escherichia coli, Photochem. Photobiol. (in press).
Roberts, M. W., and Moffa, J. P., 1973, Repair of fractured incisai angles with an ultraviolet light-activated fissure sealant and a composite resin: Two-year report of 60 cases, J. Am. Dent. Assoc. 75:121–128.
Rupert, C. S., 1968, Shapes of the UV inactivation curves for single and double linked markers of Haemophilus influenzae transforming DNA, Photochem. Photobiol. 7:437–449.
Rupert, C. S., and Goodgal, S. H., 1960, Shape of ultraviolet inactivation curves of transforming deoxyribonucleic acid, Nature (London) 185:556–557.
Rupert, C. S., and Harm, W., 1966, Reactivation after photobiological damage, in: Advances in Radiation Biology, Vol. 2 (L. G. Augenstein, R. Mason, and M. Zelle, eds.), pp. 1–81, Academic Press, New York.
Rupp, W. D., and Howard-Flanders, P., 1968, Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation, J. Mol. Biol. 31:291–304.
Scotto, J., Kopf, A. W., and Urbach, F., 1974, Non-melanoma skin cancer among Caucasians in four areas of the United States, Cancer 34:1333–1338.
Setlow, J. K., 1967, The effects of ultraviolet radiation and photoreactivation, in: Comprehensive Biochemistry, Photobiology, Ionizing Radiations (M. Florkin and E. H. Stotz, eds.), pp. 157–203, Elsevier, New York.
Setlow, J. K., and Boling, M. E., 1965, The resistance of Micrococcus radiodurans to ultraviolet radiation. II. Action spectra for killing, delay in DNA synthesis, and thymine dimerization, Biochim. Biophys. Acta 108:259–265.
Setlow, R. B., 1964, Physical changes and mutagenesis, J. Cell Comp. Physiol. 64:51–68 (Suppl. 1).
Setlow, R. B., 1966, Cyclubutane-type pyrimidine dimers in polynucleotides, Science 153:379–386.
Setlow, R. B., 1968, Photoproducts in DNA irradiated in vivo, Photochem. Photobiol. 7:643–649.
Setlow, R. B., 1974, Wavelengths in sunlight effective in producing skin cancer: A theoretical analysis, Proc. Natl. Acad. Sci. USA 71:3363–3366.
Setlow, R. B., and Carrier, W. L., 1966, Pyrimidine dimers in ultraviolet-irradiated DNA’s, J. Mol. Biol. 17:237–254.
Setlow, R. B., and Hart, R. W., 1975, Direct evidence that damaged DNA results in neoplastic transformation—a fish story, in: Radiation Research, Biochemical, Chemical, and Physical Perspectives (O. F. Nygaard, H. I. Adler, and W. K. Sinclair, eds.), pp. 879–884, Academic Press, New York.
Setlow, R. B., and Setlow, J. K., 1972, Effects of radiation on polynucleotides, Ann. Rev. Biophys. Bioeng. 1:293–346.
Sisson, T. R. C., 1976, Visible light therapy of neonatal hyperbilirubinemia, in: Photochemical and Photobiological Reviews, Vol. 1 (K. C. Smith, ed.), pp. 241–268, Plenum Publishing Co., New York.
Sisson, T. R. C., Glauser, S. C., Glauser, E. M., and Kumabara, T., 1970, Retinal changes produced by phototherapy, J. Pediatr. 77:221–227.
Sistrom, W. R., Griffiths, M., and Stanier, R. Y., 1956, The biology of photosynthetic bacterium which lacks colored carotenoids, J. Cell. Comp. Physiol. 48:473–515.
Smith, K. C., 1971, Roles of genetic recombination and DNA polymerase in repair of damaged DNA, in: Photophysiology, Vol. 6 (A. C. Giese, ed.), pp. 209–278, Academic Press, New York.
Smith, K. C., 1974a, Molecular changes in nucleic acids produced by ultraviolet and visible radiation in: Sunlight and Man (T. B. Fitzpatrick, M. A. Pathak, L. C. Harber, M. Seiji, and A. Kukita, eds.), pp. 57–66, University of Tokyo Press, Tokyo.
Smith, K. C., 1974b, Cellular repair and radiation damage, in: Sunlight and Man (T. B. Fitzpatrick, M. A. Pathak, L. C. Harber, M. Seiji, and A. Kukita, eds.), pp. 67–77, University of Tokyo Press, Tokyo.
Smith, K. C., and Hanawalt, P. C., 1969, Molecular Photobiology: Inactivation and Recovery, Academic Press, New York.
Speck, W. T., and Rosenkranz, H. S., 1975, Base substitution mutations induced in Salmonella strains by visible light, Photochem. Photobiol. 21:369–371.
Spikes, J. D., 1968, Photodymatic action, in: Photophysiology, Vol. 3 (A. C. Giese, ed.), pp. 33–64, Academic Press, New York.
Spikes, J. D., and Livingston, R., 1969, The molecular biology of photodynamic action, in: Advances in Radiation Biology, Vol. 3 (L. G. Augenstein, R. Mason, and M. Zelle, eds.), pp. 29–121, Academic Press, New York.
Sprott, G. D., Dimock, K., Martin, W. G., and Schneider, H., 1975, Coupling of glycine and alanine transport to respiration in cells of Escherichia coli, Can. J. Biochem. 53:262–268.
Stanier, R. Y., 1959, Formation and function of photosynthetic pigment system in purple bacteria, Brookhaven Symp. Biol. 11:43–53.
Stanier, R. Y., and Cohen-Bazire, G., 1957, The role of light in the microbial world: Some facts and speculation, Symp. Soc. Gen. Microbiol. 7:56–89.
Stanier, R. Y., and Straight, R., 1967, Sensitized photochemical processes in biological systems, Annu. Rev. Phys. Chem. 18:405–436.
Stoien, J. D., and Wang, R. J., 1974, Effect of near-ultraviolet and visible light on mammalian cells in culture. II. Formation of toxic photoproducts in tissue culture medium by blacklight, Proc. Natl. Acad. Sci. USA 71:3961–3965.
Stuy, J. H., 1965, Fate of transforming DNA in Haemophilus influenzae transforming system, J. Mol. Biol. 13:554–570.
Stuy, J. H., 1974, Acid-soluble breakdown of homologous DNA absorbed by Haemophilus influenzae: Its biological significance, J. Bacteriol. 120:917–922.
Swenson, P. A., 1976, Physiological responses of Escherichia coli to far-ultraviolet radiation, in: Photochemical and Photobiological Reviews, Vol. 1 (K. C. Smith, ed.), pp 269–387, Plenum Publishing Co., New York.
Swenson, P. A., and Schenley, R. L., 1970, Role of pyridine nucleotides in the control of respiration in ultraviolet-irradiated Escherichia coli B/r cells, J. Bacteriol. 104:1230–1235.
Swenson, P. A., and Schenley, R. L., 1974, Evidence relating cessation of respiration, cell envelope changes, and death in ultraviolet-irradiated Escherichia coli B/r cells, J. Bacteriol. 117:551–559.
Swenson, P. A., and Setlow, R. B., 1970, Inhibition of the induced formation of tryptophanase in Escherichia coli by near-ultraviolet radiation, J. Bacteriol. 102:815–819.
Szybalski, W., and Opara-Kubinska, L., 1965, Radiobiological and physiochemical properties of 5-bromodeoxyuridine-labelled transforming DNA as related to the nature of the critical radiosensitive structures, in: Cellular Radiation Biology, pp. 223–240, Williams and Wilkins, Baltimore.
Town, C. D., Smith, K. C., and Kaplan, H. S., 1973, Repair of X-ray damage to bacterial DNA, Curr. Top. Radiat. Res. Q. 8:351–399.
Tuveson, R. W., and Satterthwaite, M. A., 1976, Comparison of ultraviolet and blacklight for the induction of nutritional independence at two loci in Neurospora crassa, Mutat. Res. 36:165–170.
Tyrrell, R. M., 1973, Induction of pyrimidine dimers in bacterial DNA by 365 nm radiation Photochem. Photobiol. 17:69–73.
Tyrrell, R. M., 1974, The interaction of near-UV (365 nm) and X-radiations on wild-type and repair-deficient strains of Escherichia coli K12: Physical and biological measurements, Int. J. Radiat. Biol. 25:373–390.
Tyrrell, R. M., 1976a, RecA +-dependent synergism between 365 nm and ionizing radiation in log-phage Escherichia coli: A model for oxygen-dependent near-UV inactivation by disruption of DNA repair, Photochem. Photobiol. 23:13–20.
Tyrrell, R. M., 1976b, Synergistic lethal action of ultraviolet-violet radiations and mild heat in Escherichia coli, Photochem. Photobiol. 24:345–352.
Tyrrell, R. M., and Davies, D. J. G., 1974, The kinetics of photoreactivation in the ultraviolet sensitive mutant Escherichia coli K12 AB2480, Mutat. Res. 23:151–161.
Tyrrell, R. M., and Webb, R. B., 1973, Reduced dimer excision following near ultraviolet (365 nm) radiation, Mutat. Res. 19:361–364.
Tyrrell, R. M., Moss, S. H., and Davies, D. J. G., 1972a, The variation in UV sensitivity of four K12 strains of Escherichia coli as a function of their stage of growth, Mutat. Res. 16:1–12.
Tyrrell, R. M., Moss, S. H., and Davies, D. J. G., 1972b, The variation in photoreactivating enzyme activity as a function of stage of growth of three K12 strains of Escherichia coli, Mutat. Res. 16:345–352.
Tyrrell, R. M., Webb, R. B., and Brown, M. S., 1973, Destruction of photoreactivating enzyme by 365 nm radiation, Photochem. Photobiol. 18:249–254.
Tyrrell, R. M., Ley, R. D., and Webb, R. B., 1974, Induction of single-strand breaks (alkalilabile bonds) in bacterial and phage DNA by near-UV (365 nm) radiation, Photochem. Photobiol. 20:395–398.
Urbach, F., Epstein, J. H., and Forbes, P. D., 1974, Ultraviolet carcinogenesis: Experimental, global, and genetic aspects, in: Sunlight and Man (T. B. Fitzpatrick, M. A. Pathak, L. C. Harber, M. Seiji, and A. Kukita, eds.), pp. 260–283, University of Tokyo Press, Tokyo.
Van der Schueren, E., and Smith, K. C., 1974, Inhibition of the exrA gene-dependent branch of the DNA excision repair system in Escherichia coli K-12 by 2,4-dinitrophenol, Photochem. Photobiol. 19:95–102.
Van der Schueren, E., Smith, K. C., and Kaplan, H. S., 1973, Modification of DNA repair and survival of X-irradiated pol, rec, and exr mutants of Escherichia coli K-12 by 2,4-dinitrophenol, Radiat. Res. 55:346–355.
Venema, G., Pritchard, R. H., and Venema-Schröder, T., 1965, Fate of transforming deoxyribonucleic acid in Bacillus subtilis, J. Bacteriol. 89:1250–1255.
Wahl, R., 1946, Quelques précisions au sujet de l’action de la lumière sur les bactériophages, Ann. Inst. Pasteur 72:284–286.
Wahl, R., and Latarjet, R., 1947, Near-UV inactivation of several bacteriophages maximum in the near UV and violet regions, Ann. Inst. Pasteur 73:957–971.
Walter, J. F., and Voorhees, J. J., 1973, Psoriasis improved by psoralen plus black light, Acta Derm. Venereol. (Stockholm) 53:469–472.
Wang, R. J., Stoien, J. D., and Landa, F., 1974, Lethal effect of near-ultraviolet irradiation on mammalian cells in culture, Nature (London) 247:43–45.
Webb, R. B., 1972, Photodynamic lethality and mutagenesis in the absence of added sensitizers, in: Organic, Biological and Medicinal Chemistry, Vol. 3 (U. Galo and L. Santamaria, eds.), Part 2, pp. 511–530, American Elsevier, New York.
Webb, R. B., 1977a, Near-ultraviolet mutagenesis. I. Photoreactivation of mutational lesions induced by 365 nm radiation in Escherichia coli WP2B, J. Bacteriol. (submitted).
Webb, R. B., 1977b, Near-ultraviolet mutagenesis, II. Mutation induction by 365 nm radiation in strains of Escherichia coli that differ in repair capability, Mutat. Res. (submitted).
Webb, R. B., and Brown, M. S., 1976, Sensitivity of strains of Escherichia coli differing in repair capability to far UV, near UV and visible radiations, Photochem. Photobiol. 24:425–432.
Webb, R. B., and Brown, M. S., 1977a, Strong synergism between 365 nm and longer wavelength radiation in repair-proficient strains of E. coli (in preparation).
Webb, R. B., and Brown, M. S., 1977b, Oxygen dependence of sensitization to 254 nm radiation by prior exposures to 365 nm radiation (in preparation).
Webb, R. B., and Kubitschek, H. E., 1963, Mutagenic and antimutagenic effects of acridine orange in Escherichia coli, Biochem. Biophys. Res. Commun. 13:90–94.
Webb, R. B., and Kubitschek, H. E., 1965, Photodynamic mutation in continuous cultures, in: Argonne National Laboratory Biology and Medicine AEC Research and Development Report, ANL-7136, pp. 145-148.
Webb, R. B., and Lorenz, J. R., 1970, Oxygen dependence and repair of lethal effects of near ultraviolet and visible light, Photochem. Photobiol. 12:283–289.
Webb, R. B., and Malina, M. M., 1967, Mutagenesis in Escherichia coli by visible light, Science 156:1104–1105.
Webb, R. B., and Malina, M. M., 1970, Mutagenic effects of near ultraviolet and visible radiant energy on continuous cultures of Escherichia coli, Photochem. Photobiol. 12:457–468.
Webb, R. B., Brown, M. S., and Tyrrell, R. M., 1976, Lethal effects of pyrimidine dimers induced at 365 nm in strains of E. coli differing in repair capability, Mutat. Res. 37:163–172.
Webb, R. B., Brown, M. S., and Hass, B. S., 1977a, Action spectrum for carotenoid protection in Sarcina lutea, Radiat. Res. (submitted).
Webb, R. B., Tyrrell, R. M., and Brown, M. S., 1977b, Synergism between 365 and 254 nm radiation (in preparation).
Webb, R. B., Ley, R. D., and Hass, B. S., 1977c, The role of oxygen-dependent lesions and damage to repair processes in the oxygen-dependent inactivation of E. coli by 365 nm radiation, in preparation.
Webb, S. J., 1963, The effect of relative humidity and light on air-dried organisms, J. Appl. Bacteriol. 26:307–313.
Webb, S. J., 1972, Semi-dehydration and the action of ultraviolet light, in: Research Progress in Organic, Biological and Medicinal Chemistry, Vol. 3 (U. Gallo and L. Santamaria, eds.), Part 2, pp. 737–753, American Elsevier, New York.
Webb, S. J., and Bhorjee, J. S., 1967, The effect of 3000-4000 Å light on the synthesis of B. galactosidase and bacteriophages by Escherichia coli B, Can. J. Microbiol. 13:69–79.
Webb, S. J., and Tai, C. C., 1968, Lethal and mutagenic action of 3200-4000 Å light, Can. J. Microbiol. 14:727–735.
Webb, S. J., and Tai, C. C., 1969, Physiological and genetic implications of selective mutation by light at 320-400 nm, Nature (London) 224:1123–1125.
Webb, S. J., and Tai, C. C., 1970, Differential, lethal and mutagenic action of 254 nm and 320-400 nm radiation on semi-dried bacteria, Photochem. Photobiol. 12:119–143.
Weber, G., 1974, Combined 8-methoxypsoralen and black light therapy of psoriasis: Technique and results, Br. J. Dermatol. 90:317–323.
Wells, W. F., 1955, Air Hygiene and Air Contagion, Harvard University Press, Boston.
Wells, W. F., and Wells, N. W., 1936, Air-borne infection, J. Am. Med. Assoc. 107:1698–1703.
Willis, I., Kligman, A., and Epstein, J., 1973, Effects of long ultraviolet rays on human skin: Photoprotective or photoaugmentative, J. Invest. Dermatol. 59:416–420.
Witkin, E. M., 1963, The effect of acriflavine on photoreversal of lethal and mutagenic damage produced in bacteria by ultraviolet light, Proc. Natl. Acad. Sci. USA 50:425–430.
Witkin, E. M., 1975, Elevated mutability of polA and uvrA polA derivatives of Escherichia coli B/r at sublethal doses of ultraviolet light: Evidence for an inducible error-prone repair system (“SOS repair”) and its anomalous expression in these strains, Genetics 79:199–213.
Witkin, E. M., and Parisi, E. C., 1974, Bromouracil mutagenesis: Mispairing or misrepair? Mutat. Res. 25:407–409.
Wright, L. J., and Rilling, H. C., 1963, The function of carotenoids in a photochromogenic bacterium, Photochem. Photobiol. 2:339–342.
Wulff, D. L., and Fraenkel, G., 1961, On the nature of thymine photoproduct, Biochim. Biophys. Acta 51:332–339.
Wurtman, R. J., 1975, The effects of light on man and other animals, Annu. Rev. Physiol. 37:467–483.
Yoakum, G. H., 1975, Tryptophan photoproduct(s): Sensitized induction of strand breaks (or alkali-labile bonds) in bacterial deoxyribonucleic acid during near-ultraviolet irradiation, J. Bacteriol. 122:199–205.
Yoakum, G., and Eisenstark, A., 1972, Toxicity of L-tryptophan photoproduct on recombinationless (rec) mutants of Salmonella typhimurium, J. Bacteriol. 112:653–655.
Yoakum, G., Ferron, W., Eisenstark, A., and Webb, R. B., 1974, Inhibition of replication gap closure in Escherichia coli by near-ultraviolet light photoproducts of L-tryptophan, J. Bacteriol. 119:62–69.
Yoakum, G., Eisenstark, A., and Webb, R. B., 1975, Near-UV photoproduct(s) of L-tryptophan: An inhibitor of medium-dependent repair of X-ray-induced single-strand breaks in DNA which also inhibits replication-gap closure in Escherichia coli DNA; molecular mechanisms for repair of DNA, in: Molecular Mechanism for Repair of DNA (P. C. Hanawalt and R. B. Setlow, eds.), Part B, pp. 453–458, Plenum Press, New York.
Yoakum, G., Webb, R. B., and Eisenstark, A., 1977, Toxic photoproducts of L-tryptophan: A role in near-UV sensitivity of Salmonella typhimurium recA strains, Photochem. Photobiol. (submitted).
Youngs, D. A., Van der Schueren, E., and Smith, K. C., 1974, Separate branches of the uvr gene-dependent excision repair process in ultraviolet-irradiated Escherichia coli K-12 cells; their dependence upon growth medium and the polA, recA, recB and exrA genes, J. Bacteriol. 117:717–725.
Zelle, M. R., and Hollaender, A., 1955, Effects of radiation on bacteria, in: Radiation Biology. Vol. 2 (A. Hollaender, ed.), pp. 365–430, McGraw-Hill, New York.
Zetterberg, G., 1964, Mutagenic effects of ultraviolet and visible light, in: Photophysiology, Vol. 3 (A. C. Giese, ed.), pp. 247–281, Academic Press, New York.
Zigman, S., 1971, Eye lens color: Formation and function, Science 171:807–809.
Zigman, S., and Hare, J. D., 1976, Inhibition of cell growth by near ultraviolet light photoproducts of tryptophan, Mol. Cell. Biochem. 10:131–135.
Zigman, S., Schultz, J., Yulo, T., and Griess, G., 1973, The binding of photo-oxidized tryptophan to a lens gamma-crystallin, Exp. Eye Res. 17:209–217.
Zigman, S., Yulo, T., and Schultz, J., 1974, Cataract induction in mice exposed to near UV light, Ophthalmic Res. 6:259–270.
Zirenberg, B. E., Kramer, D. M., Geisert, M. G., and Kirste, R. G., 1971, Effects of sensitized and unsensitized longwave UV-irradiation on the solution properties of DNA, Photochem. Photobiol. 14:515–520.
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Webb, R.B. (1977). Lethal and Mutagenic Effects of Near-Ultraviolet Radiation. In: Smith, K.C. (eds) Photochemical and Photobiological Reviews. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2577-2_4
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