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Photochemistry of the Nucleic Acids

  • Leonhard Kittler
  • Günter Löber

Abstract

Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) contain four major bases—adenine, guanine, cytosine, and thymine (uracil instead of thymine in RNA)—each of which strongly absorbs ultraviolet (UV) radiation with a maximum at about 260 nm. Therefore, UV irradiation of nucleic acids and related model compounds produces electronically excited bases that are able to undergo various photochemical reactions involving neighboring bases, sugar residues, surrounding water molecules, proteins, and bound organic ligands. The photochemical properties of minor bases and base analogues usually differ from those of the major normal bases. In view of this, the study of photochemical processes may well lead to important advances in the recognition of their biochemical functions.

Keywords

Methylene Blue Triplet State Singlet Oxygen Acridine Orange Orotic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Leonhard Kittler
    • 1
  • Günter Löber
    • 1
  1. 1.Forschungszentrum für Molekularbiologie und Medizin, Zentralinstitut für Mikrobiologie und experimentelle Therapie Jena, Abteilung BiophysikochemieAkademie der Wissenschaften der DDRJenaGermany

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