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Stereospecific Synthesis of Enantiomeric Acylglycerols

  • Dmytro Buchnea
Part of the Handbook of Lipid Research book series (HLRE, volume 1)

Abstract

The natural triacylglycerols are mixtures of glycerol esters containing one, two, or three different fatty acids per molecule. By means of stereospecific analysis of the mixed triacylglycerols, it has been possible to demonstrate that they are made up largely of asymmetrical or enantiomeric molecules. The isolation and identification of individual acylglycerols from such mixtures have proved extremely difficult because of the large variety of fatty acids represented and the great similarity in the physicochemical properties of their glycerol esters. With modern chromatographic methods, it has been possible to separate and identify natural triacylglycerols on the basis of their fatty acid composition, but a resolution of the positional isomers and enantiomers has not been achieved. Stereospecific chemical synthesis therefore remains the only means of obtaining pure enantiomeric triacylglycerols for physico-chemical and metabolic studies.

Keywords

Protective Group Acyl Migration Cotton Effect Glycerol Molecule Stereospecific Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Dmytro Buchnea
    • 1
  1. 1.Banting and Best Department of Medical ResearchUniversity of TorontoTorontoCanada

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