Biologic Aspects of Leukocyte Chemotaxis

  • Ralph Snyderman
  • Marilyn Pike
Part of the Comprehensive Immunology book series (COMIMUN, volume 2)

Abstract

To protect a host against microbial invasion and the development of neoplasms, the immune system must discriminate self from nonself and then efficiently localize and eliminate material recognized as nonself. The process of localizing, degrading, and eliminating nonself can be termed an immune effector function and is largely mediated by the accumulation of wandering phagocytic cells, such as polymorpho-nuclear leukocytes (PMNs) and macrophages. One process that could result in the local accumulation of immune effector cells is chemotaxis, the unidirectional migration of cells along a concentration gradient of a chemoattractant substance. During the past decade, it has clearly been shown that the interaction of lymphocytes or immunoglobulins with antigens can result in the production or release of biologically active products that are capable of enhancing vascular permeability and attracting leukocytes. The production of chemotactic gradients as well as the ability of wandering cells to respond normally to such gradients appears to be critical for immunologically mediated host defense. Dysfunctions of leukocyte chemotaxis may render an individual more susceptible to infectious, inflammatory, and perhaps neoplastic diseases. In this chapter, we will review methodology for quantifying chemotaxis, describe factors that are chemotactic for polymorphonuclear leukocytes, and discuss recent observations of abnormalities of human leukocyte chemotaxis and their relationship to human disease states.

Keywords

Migration Depression Adenocarcinoma Fractionation Histamine 

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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Ralph Snyderman
    • 1
  • Marilyn Pike
    • 2
  1. 1.Division of Rheumatic and Genetic DiseasesDuke University Medical CenterDurhamUSA
  2. 2.Department of MedicineDuke University Medical CenterDurhamUSA

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