Serum Bactericidal Activity and Complement

  • Louis H. Muschel
  • Jack S. C. Fong
Part of the Comprehensive Immunology book series (COMIMUN, volume 2)


The bactericidal reaction provided the first demonstration of the existence and cooperative effect of a thermostable substance, which is peculiar to immune serum, and a thermolabile substance, which is present in both normal and fresh immune serum. This discovery by Bordet (1895) that the killing of Vibrio cholerae by serum was mediated by antibody and complement (C) represents a very significant landmark in the history of serology and immunochemistry.


Bactericidal Activity Natural Antibody Complement Deficiency Serum Bactericidal Activity Bactericidal Antibody 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Louis H. Muschel
    • 1
  • Jack S. C. Fong
    • 2
  1. 1.Research DepartmentAmerican Cancer SocietyNew YorkUSA
  2. 2.Department of PediatricsMcGill UniversityMontrealCanada

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