• Frank M. GriffinJr.
Part of the Comprehensive Immunology book series (COMIMUN, volume 2)


Opsonin is a term introduced by Wright and Douglas (1903) to designate a factor (or factors) in serum that interacts with particles in a manner that renders the particles more readily ingested by phagocytic cells. In this chapter, we will consider the mechanisms by which opsonins interact with the particles they coat and with the phagocytic cells to which they bind and the role opsonization plays in host defense against invasion by microorganisms.


Phagocytic Cell Mouse Peritoneal Macrophage Alternate Complement Pathway Intracellular Killing Subacute Bacterial Endocarditis 
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  1. Abramson, N., Gelfand, E. W., Jandl, J. H., Rosen, F. S., 1970a, The interaction between human monocytes and red cells. Specificity for IgG subclasses and IgG fragments, J. Exp. Med. 132: 1207–1215.PubMedGoogle Scholar
  2. Abramson, N., Lo Buglio, A. F., Jandl, J. H., Cotran, R. S., 1970b, The interaction between human monocytes and red cells. Binding characteristics, J. Exp. Med. 132: 1191–1206.PubMedGoogle Scholar
  3. Allison, A. C., Davies, P., de Petris, S., 1971, Role of contractile microfilaments in macrophage movement and endocytosis, Nature London New Biol. 232: 153–155.Google Scholar
  4. Alper, C. A., Propp, R. P., Klemperer, M. R., Rosen, F. S., 1969, Inherited deficiency of the third 105 component of human complement (C′3), J. Clin. Invest. 48: 553–557.PubMedGoogle Scholar
  5. Alper, C. A., Abramson, N., Johnston, R. B., Jr., Jandl, J. H., Rosen, F. S., 1970a, Increased susceptibility to infection associated with abnormalities of complement-mediated functions and of the third component of complement (C3), N. Engl. J. Med. 282: 349–354.Google Scholar
  6. Alper, C. A., Abramson, N., Johnston, R. B., Jr., Jandl, J. H., Rosen, F. S., 1970b, Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection, J. Clin. Invest. 49: 1975–1985.PubMedGoogle Scholar
  7. Alper, C. A., Colten, H. R., Rosen, F. S., Rabson, A. R., Macnab, G. M., Gear, J. S. S., 1972, Homozygous deficiency of C3 in a patient with repeated infections, Lancet 2: 1179–1181.PubMedGoogle Scholar
  8. Alper, C. A., Bloch, K. J., Rosen, F. S., 1973, Increased susceptibility to infection in a patient with type II essential hypercatabolism of C3, N. Engl. J. Med. 288: 601–606.PubMedGoogle Scholar
  9. Anderson, P., Johnston, R. B., Jr., Smith, D. H., 1972a, Human serum activities against Hemophilus influenzae, type by, J. Clin. Invest. 51: 31–38.PubMedGoogle Scholar
  10. Anderson, P., Peter, G., Johnston, R. B., Jr., Wetterlow, L. H., Smith, D. H., 1972b, Immunization of humans with polyribophosphate, the capsular antigen of Hemophilus influenzae, type b, J. Clin. Invest. 51: 39–44.PubMedGoogle Scholar
  11. Arend, W. P., Mannik, M., 1973, The macrophage receptor for IgG: number and affinity of binding sites, J. Immunol. 110: 1455–1463.PubMedGoogle Scholar
  12. Askenase, P. W., Hayden, B. J., 1974, Cytophilic antibodies in mice contactsensitized with oxazolone. Immunochemical characterization and preferential binding to a trypsin-sensitive macrophage receptor, Immunology 27: 563–576.PubMedGoogle Scholar
  13. Atkinson, J. P., Frank, M. M., 1974a, The effect of bacillus Calmette-Guérin-induced macrophage activation on the in vivo clearance of sensitized erythrocytes, J. Clin. Invest. 53: 1742–1749.PubMedGoogle Scholar
  14. Atkinson, J. P., Frank, M. M., 1974b, Studies of the in vivo effects of antibody. Interaction of IgM antibody and complement in the immune clearance and destruction of erythrocytes in man, J. Clin. Invest. 54: 339–348.PubMedGoogle Scholar
  15. Ballow, M., Yang, S. Y., Day, N. K., 1975, Complete absence of the third component of complement, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 34: 853.Google Scholar
  16. Basch, R. S., 1965, Inhibition of the third component of the complement system by derivatives of aromatic amino acids, J. Immunol. 94: 629–640.PubMedGoogle Scholar
  17. Berken, A., Benacerraf, B., 1966, Properties of antibodies cytophilic for macrophages, J. Exp. Med. 123: 119–144.PubMedGoogle Scholar
  18. Berken, A., Benacerraf, B., 1968, Sedimentation properties of antibodies cytophilic for macrophages, J. Immunol. 100: 1219–1222.PubMedGoogle Scholar
  19. Bianco, C., Griffin, F. M., Jr., Silverstein, S. C., 1975, Studies of the macrophage complement receptor. Alteration of receptor function upon macrophage activation, J. Exp. Med. 141: 1278–1290.PubMedGoogle Scholar
  20. Bjornson, A. B., Michael, J. G., 1971, Contribution of humoral and cellular factors to the resistance to experimental infection by Pseudomonas aeruginosa in mice. I. Interaction between immunoglobulins, heat-labile serum factors, and phagocytic cells in the killing of bacteria, Infect. Immun. 4: 462–467.PubMedGoogle Scholar
  21. Bjornson, A. B., Michael, J. G., 1973, Factors in normal human serum that promote bacterial phagocytosis, J. Infect. Dis. 128: S182–S186.Google Scholar
  22. Bokisch, V. A., Sobel, A. T., 1974, Receptor for the fourth component of complement on human ? lymphocytes and cultured human lymphoblastoid lines, J. Exp. Med. 140: 1336–1347.PubMedGoogle Scholar
  23. Borsos, T., Rapp, H. J., 1965a, Hemolysin titration based on fixation of the activated first component of complement: evidence that one molecule of hemolysin suffices to sensitize an erythrocyte, J. Immunol. 95: 559–566.PubMedGoogle Scholar
  24. Borsos, T., Rapp, H. J., 1965b, Complement fixation on cell surfaces by 19 S and 7 S antibodies, Science 150: 505–506.PubMedGoogle Scholar
  25. Boxer, L. A., Hedley-White, E. T., Stossel, T. P., 1974, Neutrophil actin dysfunction and abnormal neutrophil behavior, N. Engl. J. Med. 291: 1093–1099.PubMedGoogle Scholar
  26. Boyden, S. V., 1964, Cytophilic antibody in guinea-pigs with delayed-type hypersensitivity, Immunology 7: 474–483.PubMedGoogle Scholar
  27. Boyden, S. V., Sorkin, E., 1960, The adsorption of antigen by spleen cells previously treated with antiserum in vitro, Immunology 3: 272–283.PubMedGoogle Scholar
  28. Boyden, S. V., Sorkin, E., 1961, The absorption of antibody and antigen by spleen cells in vitro. Some further observations, Immunology 4: 244–252.Google Scholar
  29. Boyden, S. V., North, R. J., Faulkner, S. M., 1965, Complement and the activity of phagocytes, in: Ciba Foundation Symposium: Complement ( G. E. W. Wolstenholme and J. Knight, eds.), pp. 190–213, Little, Brown and Co., Boston.Google Scholar
  30. Brown, D. L., Lachmann, P.J., Dacie, J. V., 1970, The in vivo behaviour of complement-coated red cells: studies in C6-deficient, C3-depleted and normal rabbits, Clin. Exp. Immunol. 7: 401–421.PubMedGoogle Scholar
  31. Bulloch, W., Western, G. T., 1906, The specificity of the opsonic substances in the blood serum, Proc. Roy. Soc. London Ser. B 77: 531–536.Google Scholar
  32. Cohen, S., 1968, The requirement for the association of two adjacent rabbit γG-antibody molecules in the fixation of complement by immune complexes, J. Immunol. 100: 407–413.PubMedGoogle Scholar
  33. Cohen, S., Butcher, G. A., 1970, Properties of protective malarial antibody, Immunology 19: 369–383.PubMedGoogle Scholar
  34. Cohn, Z. A., 1963, The fate of bacteria within phagocytic cells. II. The modification of intracellular degradation, J. Exp. Med. 117: 43–53.PubMedGoogle Scholar
  35. Cohn, Z. A., Morse, S. I., 1959, Interactions between rabbit polymorphonuclear leucocytes and staphylococci, J. Exp. Med. 110: 419–443.PubMedGoogle Scholar
  36. Cooper, N. R., 1967, Complement associated peptidase activity of guinea pig serum. II. Role of a low molecular weight enhancing factor, J. Immunol. 98: 132–138.PubMedGoogle Scholar
  37. Cooper, N. R., 1969, Immune adherence by the fourth component of complement, Science 165: 396–398.PubMedGoogle Scholar
  38. Cooper, N. R., Becker, E. L., 1967, Complement associated peptidase activity of guinea pig serum. I. Role of complement components, J. Immunol. 98: 119–131.PubMedGoogle Scholar
  39. Cooper, N. R., Miiller-Eberhard, H. J., 1967, Quantitative relation between peptidase activity and the cell-bound second (C′2), third (C′3) and fourth (C′4) components of human complement (C′), Fed. Proc. Fed. Amer. Soc. Exp. Biol. 26: 361.Google Scholar
  40. Cooper, N. R., ten Bensel, R., Kohler, P. F., 1968, Studies of an additional kindred with hereditary deficiency of the second component of human complement (C2) and description of a new method for the quantitation of C2, J. Immunol. 101: 1176–1182.PubMedGoogle Scholar
  41. Cowie, D. M., Chapin, W. S., 1907a, On the reaction of heated normal human opsonic serum with fresh diluted serum. A contribution to the study of opsonins, J. Med. Res. 17: 57–75.PubMedGoogle Scholar
  42. Cowie, D. M., Chapin, W. S., 1907b, Experiments in favor of the amboceptor-complement structure of the opsonin of normal human serum for the Staphylococcus albus, J. Med. Res. 17: 95–117.PubMedGoogle Scholar
  43. Dales, S., Kajioka, R., 1964, The cycle of multiplication of vaccinia virus in Earle’s strain L cells. I. Uptake and penetration, Virology 24: 278–294.PubMedGoogle Scholar
  44. Davis, B. D., Dulbecco, R., Eisen, H. N., Ginsberg, H. S., Wood, W. B., Jr., 1968, Microbiology, p. 609, Harper, New York.Google Scholar
  45. Diamond, R. D., May, J. E., Kane, M., Frank, M. M., Bennett, J. E., 1973, The role of late complement components and the alternate complement pathway in experimental cryptococcosis, Proc. Soc. Exp. Biol. Med. 144: 312–315.PubMedGoogle Scholar
  46. Dossett, J. H., Williams, R. C., Jr., Quie, P. G., 1969, Studies on interaction of bacteria, serum factors and polymorphonuclear leukocytes in mothers and newborns, Pediatrics 44: 49–57.PubMedGoogle Scholar
  47. Dubos, R. J., 1945, The Bacterial Cell, pp. 205–212, Harvard University Press, Cambridge, Massachusetts.Google Scholar
  48. Dukor, P., Hartmann, K. U., 1973, Bound C3 as the second signal for B-cell activation, Cell. Immunol. 7: 349–356.Google Scholar
  49. Eddies, D. S., Schulkind, M. L., Robbins, J. B., 1971, The isolation and biologic activities of purified secretory IgA and IgG anti-Salmonella typhimurium “O” antibodies from rabbit intestinal fluid and colostrum, J. Immunol. 106: 181–190.Google Scholar
  50. Ehlenberger, A. G., Nussenzweig, V., 1975, Synergy between receptors for Fc and C3 in the induction of phagocytosis by human monocytes and neutrophils, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 34: 854.Google Scholar
  51. Ellman, L., Green, I., Frank, M. M., 1970, Genetically controlled total deficiency of the fourth component of complement in the guinea pig, Science 170: 74–75.PubMedGoogle Scholar
  52. Estes, D., Christian, C. L., 1971, The natural history of systemic lupus erythematosus by prospective analysis, Medicine 50: 85–95.PubMedGoogle Scholar
  53. Fearon, D. T., Ruddy, S., Schur, P. H., McCabe, W. R., 1975, Activation of the properdin pathway of complement in patients with gram-negative bacteremia, N. Engl. J. Med. 292: 937–940.PubMedGoogle Scholar
  54. Feinstein, A., Rowe, A. J., 1965, Molecular mechanism of formation of an antigen-antibody complex, Nature (London) 205: 147–149.Google Scholar
  55. Fine, D. P., Marney, S. R., Colley, D. G., Sergent, J. S., Des Prez, R. M., 1972, C3 shunt activation in human serum chelated with EGTA, J. Immunol. 109: 807–809.PubMedGoogle Scholar
  56. Forsgren, A., Quie, P. G., 1974, Opsonic activity in human serum chelated with ethylene glycoltetra-acetic acid, Immunology 26: 1251–1256.PubMedGoogle Scholar
  57. Gambrill, M. R., Wisseman, C. L., Jr., 1973, Mechanisms of immunity in typhus infections. III. Influence of human immune serum and complement on the fate of Rickettsia mooseri within human macrophages, Infect. Immun. 8: 631–640.PubMedGoogle Scholar
  58. Ganrot, P. O., Kindmark, C.-O., 1969, C-reactive protein—a phagocytosis-promoting factor, Scand. J. Clin. Lab. Invest. 24: 215–219.Google Scholar
  59. Gewurz, H., Pickering, R. J., Muschel, L. H., Mergenhagen, S. E., Good, R. A., 1966, Complement- dependent biological functions in complement deficiency in man, Lancet 2: 356–359.PubMedGoogle Scholar
  60. Gewurz, H., Shin, H. S., Mergenhagen, S. E., 1968, Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components, J. Exp. Med. 128: 1049–1057.PubMedGoogle Scholar
  61. Gigli, I., Nelson, R. A., Jr., 1968, Complement dependent immune phagocytosis. I. Requirements for C′l, C′4, C′2, C′3, Exp. Cell Res. 51: 45–67.PubMedGoogle Scholar
  62. Gilbert, D. N., Barnett, J. A., Sanford, J. P., 1973, Escherichia coli bacteremia in the squirrel monkey. I. Effect of cobra venom factor treatment, J. Clin. Invest. 52: 406–413.PubMedGoogle Scholar
  63. Götze, O., Miiller-Eberhard, H. J., 1971, The C3-activator system: an alternate pathway of complement activation, Exp. Med. 134: 90s–108s.Google Scholar
  64. Götze, B., Miiller-Eberhard, H. J., 1974, The role of properdin in the alternate pathway of complement activation, J. Exp. Med. 139:44–57.Google Scholar
  65. Griffin, F. M., Jr., Silverstein, S. C., 1974, Segmental response of the macrophage plasma membrane to a phagocytic stimulus, J. Exp. Med. 139: 323–336.PubMedGoogle Scholar
  66. Griffin, F. M., Jr., Bianco, C., Silverstein, S. C., 1975a, Characterization of the macrophage receptor for complement and demonstration of its functional independence from the receptor for the Fc portion of immunoglobulin G, J. Exp. Med. 141: 1269–1277.PubMedGoogle Scholar
  67. Griffin, F. M. Jr., Griffin, J. A., Leider, J. E., Silverstein, S. C., 1975b, Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane, J. Exp. Med. 142: 1263–1282.PubMedGoogle Scholar
  68. Griffin, F. M., Jr., Griffin, J. A., Silverstein, S. C., 1976, Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgG-coated bone-marrow-derived lymphocytes, J. Exp. Med. 144: 788–809.PubMedGoogle Scholar
  69. Grossberg, A. L., Markus, G., Pressman, D., 1965, Change in antibody conformation induced by hapten, Proc. Nat. Acad. Sci. U.S.A. 54: 942–945.Google Scholar
  70. del Guercio, P., Tolone, G., Braga Andrade, F., Biozzi, G., Binaghi, R. A., 1969, Opsonic, cytophilic and agglutinating activity of guinea-pig γ2 and γM ariti-Salmonella antibodies, Immunology 16: 361–371.PubMedGoogle Scholar
  71. Handin, R. I., Stossel, T. P., 1974, Phagocytosis of antibody-coated platelets by human granulocytes, N. Engl. J. Med. 290: 989–993.PubMedGoogle Scholar
  72. Henney, C. S., Stanworth, D. R., 1966, Effect of antigen on the structural configuration of homologous antibody following antigen-antibody combination, Nature London 210: 1071–1072.PubMedGoogle Scholar
  73. Henney, C. S., Stanworth, D. R., Gell, P. G. H., 1965, Demonstration of the exposure of new antigenic determinants following antigen-antibody combination, Nature London 205: 1079–1081.PubMedGoogle Scholar
  74. Henson, P. M., 1969, The adherence of leucocytes and platelets induced by fixed IgG antibody and complement, Immunology 16: 107–121.PubMedGoogle Scholar
  75. Hirsch, J. G., 1964, Demonstration by fluorescence microscopy of adsorption onto bacteria of a heat- labile factor from guinea pig serum, J. Immunol. 92: 155–158.PubMedGoogle Scholar
  76. Hirsch, J. G., Church, A. B., 1960, Studies of phagocytosis of group A streptococci by polymorphonuclear leukocytes in vitro, J. Exp. Med. 111: 309–322.PubMedGoogle Scholar
  77. Hirsch, J. G., Strauss, B., 1964, Studies on heat-labile opsonin in rabbit serum, J. Immunol. 92: 145–154.PubMedGoogle Scholar
  78. Hokama, Y., Coleman, M. K., Riley, R. F., 1962, In vitro effects of C-reactive protein on phagocytosis, J. Bacteriol. 83: 1017–1024.PubMedGoogle Scholar
  79. Holland, P., Holland, N. H., Cohn, Z. A., 1972, The selective inhibition of macrophage phagocytic receptors by anti-membrane antibodies, J. Exp. Med. 135: 458–475.PubMedGoogle Scholar
  80. Hoy, W. E., Nelson, D. S., 1969, Studies on cytophilic antibodies. V. Alloantibodies cytophilic for mouse macrophages, Aust. J. Exp. Biol. Med. Sci. 47: 525–539.PubMedGoogle Scholar
  81. Huber, H., Douglas, S. D., 1970, Receptor sites on human monocytes for complement: binding of red cells sensitized by cold auto-antibodies, Br. J. Haematol. 19: 19–26.PubMedGoogle Scholar
  82. Huber, H., Fudenberg, H. H., 1968, Receptor sites of human monocytes for IgG, Int. Arch. Allergy Appl. Immunol. 34: 18–31.PubMedGoogle Scholar
  83. Huber, H., Polley, M. J., Linscott, W. D., Fudenberg, H. H., Miiller-Eberhard, H. J., 1968, Human JR- monocytes: distinct receptor sites for the third component of complement and for immunoglobulin G, Science 162: 1281–1283.PubMedGoogle Scholar
  84. Huber, H., Douglas, S. D., Fudenberg, H. H., 1969, The IgG receptor: an immunological marker for the characterization of mononuclear cells, Immunology 17: 7–21.PubMedGoogle Scholar
  85. Huber, H., Douglas, S. D., Huber, C., Goldberg, L. S., 1971, Human monocyte receptor sites. Failure of IgA to demonstrate cytophilia, Int. Arch. Allergy Appl. Immunol. 41: 262–267.PubMedGoogle Scholar
  86. Inchley, C., Grey, H. M., Uhr, J. W., 1970, The cytophilic activity of human immunoglobulins, J. Immunol. 105: 362–369.PubMedGoogle Scholar
  87. Ishizaka, K., 1970, Human reaginic antibodies, Anna. Rev. Med. 21: 187–200.Google Scholar
  88. Ishizaka, K., Campbell, D. H., 1959, Biological activity of soluble antigen-antibody complexes. V. Change of optical rotation by the formation of skin reactive complexes, J. Immunol. 83: 318–326.PubMedGoogle Scholar
  89. Ishizaka, T., Ishizaka, K., Borsos, T., Rapp, H. J., 1966, C′l fixation by human isoagglutinins: fixation of C′l by yG and -yM but not by y A antibody, J. Immunol. 97: 716–726.PubMedGoogle Scholar
  90. Ishizaka, K., Tomioka, H., Ishizaka, T., 1970, Mechanisms of passive sentivization, I. Presence of IgE and IgG molecules on human leukocytes, J. Immunol. 105: 1459–1467.PubMedGoogle Scholar
  91. Jacobs, J. C., Miller, M. E., 1972, Fatal familial Leiner’s disease: a deficiency of the opsonic activity of serum complement, Pediatrics 49: 225–232.PubMedGoogle Scholar
  92. Jasin, H. E., 1972, Human heat labile opsonins: evidence for their mediation via the alternate pathway of complement activation, J. Immunol. 109: 26–31.PubMedGoogle Scholar
  93. Jenkin, C. R., 1963, The effect of opsonins on the intracellular survival of bacteria, Br. J. Exp. Pathol. 44: 47–57.Google Scholar
  94. Jenkin, C. R., Benacerraf, B., 1960, In vitro studies on the interaction between mouse peritoneal macrophages and strains of salmonella and Escherichia coli, J. Exp. Med. 12: 403–417.Google Scholar
  95. Jeter, W. S., McKee, A. P., Mason, R. J., 1961, Inhibition of immune phagocytosis of Diplococcus pneumoniae by human neutrophils with antibody against complement, J. Immunol. 86: 386–391.PubMedGoogle Scholar
  96. Johnson, F. R., Agnello, V., Williams, R. C., Jr., 1972, Opsonic activity in human serum deficient in C2, J. Immunol. 109: 141–145.PubMedGoogle Scholar
  97. Johnston, R. B., Jr., Klemperer, M. R., Alper, C. A., Rosen, R. S., 1969, The enhancement of bacterial phagocytosis by serum. The role of complement components and two cofactors, J. Exp. Med. 129: 1275–1290.PubMedGoogle Scholar
  98. Johnston, R. B., Jr., Struth, G., Newman, S. L., 1972, Deficient serum opsonins in sickle cell disease, Pediatr. Res. 6: 381.Google Scholar
  99. Johnston, R. B., Jr.,Anderson, P., Rosen, F. S., Smith, D. H., 1973, Characteristics of human antibody to polyribophosphate, the capsular antigen of Hemophilus influenzae, type b, Clin. Immunol. Immunopathol. 1: 234–240.PubMedGoogle Scholar
  100. Jonas, W. E., Gurner, B. W., Nelson, D. S., Coombs, R. R. A., 1965, Passive sensitization of tissue cells. I. Passive sensitization of macrophages by guinea-pig cytophilic antibody, Int. Arch. Allergy Appl. Immunol. 28: 86–104.Google Scholar
  101. Jones, T. C., Hirsch, J. G., 1972, The interaction between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites, J. Exp. Med. 136: 1173–1194.PubMedGoogle Scholar
  102. Jones, T. C., Len, L., Hirsch, J. G., 1975, Assessment in vitro of immunity against Toxoplasma gondii, J. Exp. Med. 141: 466–482.PubMedGoogle Scholar
  103. Kaplan, M. H., Volanakis, J. E., 1974, Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reactions of CRP with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin, J. Immunol. 112: 2135–2147.PubMedGoogle Scholar
  104. Kaplan, M. E., Dalmasso, A. P., Woodson, M., 1972, Complement-dependent opsonization of incompatible erythrocytes by human secretory IgA, J. Immunol. 108: 275–278.PubMedGoogle Scholar
  105. Kindmark, C.-O., 1971, Stimulating effect of C-reactive protein on phagocytosis of various species of pathogenic bacteria, Clin. Exp. Immunol. 8: 941–948.PubMedGoogle Scholar
  106. Kindmark, C.-O., 1972, In vitro binding of human C-reactive protein by some pathogenic bacteria and zymosan, Clin. Exp. Immunol. 11: 283–289.PubMedGoogle Scholar
  107. Klemperer, M. R., Woodworth, H. C., Rosen, F. S., Austen, K. F., 1966, Hereditary deficiency of the second component of complement (C′2) in man, J. Clin. Invest. 45: 880–890.PubMedGoogle Scholar
  108. Klemperer, M. R., Austen, K. F., Rosen, F. S., 1967, Hereditary deficiency of the second component of complement (C′2) in man: further observations on a second kindred, J. Immunol. 98: 72–78.PubMedGoogle Scholar
  109. Knop, J., Breu, H., Wernet, P., Rowley, D., 1971, The relative antibacterial efficiency of IgM, IgG and IgA from pig colostrum, Aust. J. Exp. Biol. Med. Sci. 49: 405–413.PubMedGoogle Scholar
  110. Lachmann, P. J., Müller-Eberhard, H. J., 1968, The demonstration in human serum of “conglutinogen-activating factor” and its effect on the third component of complement, J. Immunol. 100: 691–698.PubMedGoogle Scholar
  111. Lawrence, D. S., Weigle, W. O., Speigelberg, H. L., 1975, Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils, J. Clin. Invest. 55: 368–376.PubMedGoogle Scholar
  112. Laxdal, T., Messner, R. P., Williams, R. C., Jr., Quie, P. G., 1968, Opsonic, agglutinating, and complement-fixing antibodies in patients with subacute bacterial endocarditis, J. Lab. Clin. Med. 71: 638–653.PubMedGoogle Scholar
  113. Lay, W. H., Nussenzweig, V., 1968, Receptors for complement on leukocytes, J. Exp. Med. 128: 991–1009.PubMedGoogle Scholar
  114. Lay, W. H., Nussenzweig, V., 1969, Ca++-dependent binding of antigen-19S antibody complexes to macrophages, J. Immunol. 102: 1172–1178.PubMedGoogle Scholar
  115. Leddy, J. P., Frank, M. M., Gaither, T., Baum, J., Klemperer, M. R., 1974, Hereditary deficiency of the sixth component of complement in man. I. Immunochemical, biologic, and family studies, J. Clin. Invest. 53: 544–553.PubMedGoogle Scholar
  116. Lehrer, R. I., Cline, M. J., 1969, Interaction of Candida albicans with human leukocytes and serum, J. Bacteriol. 98: 996–1004.PubMedGoogle Scholar
  117. Leslie, R. G. Q., Cohen, S., 1974a, Cytophilic activity of IgG2 from sera of unimmunized guinea- pigs, Immunology 27: 577–587.PubMedGoogle Scholar
  118. Leslie, R. G. Q., Cohen, S., 1974b, Cytophilic activity of IgG2 from sera of guinea-pigs immunized with bovine y-globulin, Immunology 27: 589–599.PubMedGoogle Scholar
  119. Levenson, V. I., Braude, N. I., Chernokhvostova, E. V., 1970, Adherence-promoting antibodies. The investigation of physicochemical properties of mouse anti-Vi antibodies providing immune fixation of antigen to macrophage surface, Aust. J. Exp. Biol. Med. Sci. 48: 417–427.PubMedGoogle Scholar
  120. Lo Buglio, A. F., Cotra, R. S., Jandl, J. H., 1967, Red cells coated with immunoglobulin G: binding and sphering by mononuclear cells in man, Science 158: 1582–1585.Google Scholar
  121. Logue, G. L., Rosse, W. F., Adams, J. P., 1973, Complement-dependent immune adherence measured with human granulocytes: changes in the antigenic nature of red cell-bound C3 produced by incubation in human serum, Clin. Immunol. Immunopathol. 1: 398–407.PubMedGoogle Scholar
  122. Maaloe, O., 1946, Relation between Alexin and Opsonin, Elinar Munksgaard, Copenhagen. Mantovani, B., Rabinovitch, M., Nussenzweig, V., 1972, Phagocytosis of immune complexes by macrophages. Different role of the macrophage receptor sites for complement (C3) and for immu-noglobulin (IgG), J. Exp. Med. 135: 780–792.Google Scholar
  123. Marcus, R. L., Shin, H. S., Mayer, M. M., 1971, An alternate complement pathway: C3 cleaving acitivity, not due to C4,2a, on endotoxic lipopolysaccharide after treatment with guinea pig serum; relation to properdin, Proc. Nat. Acad. Sci. U.S.A. 68: 1351–1354.Google Scholar
  124. Messner, R. P., Jelinek, J., 1970, Receptors for human γG on human neutrophils, J. Clin. Invest. 49: 2165–2171.PubMedGoogle Scholar
  125. Messner, R. P., Laxdal, T., Quie, P. G., Williams, R. C., Jr., 1968, Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis. Anti-y-globulin fac-tors and their interaction with specific opsonins, J. Clin. Invest. 47: 1109–1120.PubMedGoogle Scholar
  126. Metchnikoff, E., 1887, Sur la lutte des cellules de l’organismes centre l’invasion des microbes, Ann. Inst. Pasteur 1: 321–336.Google Scholar
  127. Miller, M. E., Nilsson, U. R., 1970, A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5), N. Engl. J. Med. 282: 354–358.PubMedGoogle Scholar
  128. Miller, M. E., Nilsson, U. R., 1974, A major role of the fifth component of complement (C5) in the opsonization of yeast particles. Partial dichotomy of function and immunochemical measurement, Clin. Immunol. Immunopathol. 2: 246–255.PubMedGoogle Scholar
  129. Miller, M. E., Seals, J., Kaye, R., Levitsky, L. C., 1968, A familial, plasma-associated defect of phagocytosis: a new cause of recurrent bacterial infections, Lancet 2: 60–63.Google Scholar
  130. Miya, F., Marcus, S., 1961, Effect of humoral factors on in vitro phagocytosis and cytopeptic activities of normal and “immune” phagocytes, J. Immunol. 86: 652–668.PubMedGoogle Scholar
  131. Morelli, R., Rosenberg, L. T., 1971, The role of complement in the phagocytosis of Candida albicans by mouse peripheral blood leukocytes, J. Immunol. 107: 476–480.PubMedGoogle Scholar
  132. Mudd, S., McCutcheon, M., Lucké, ?., 1934, Phagocytosis, Physiol Rev. 14: 210–275.Google Scholar
  133. Müller-Eberhard, H. J., 1968, Chemistry and reaction mechanisms of complement, Adv. Immunol. 8: 1–80.PubMedGoogle Scholar
  134. Müller-Eberhard, H. J., 1971, Biochemistry of complement, in: Progress in Immunology ( B. Amos, ed.), pp. 553–565, Academic Press, New York.Google Scholar
  135. Müller-Eberhard, H. J., Gotze, O., 1972, C3 proactivator convertase and its mode of action, J. Exp. Med. 135: 1003–1008.PubMedGoogle Scholar
  136. Müller-Eberhard, H. J., Polley, M. J., Caicott, M. A., 1967, Formation and functional significance of a molecular complex derived from the second and fourth component of human complement, J. Exp. Med. 125: 359–380.PubMedGoogle Scholar
  137. Nelson, D. S., Mildenhall, P., 1968, Studies on cytophilic antibodies. ?. The production by guinea pigs of macrophage cytophilic antibodies to sheep erythrocytes and human serum albumin: relationship to the production of other antibodies and the development of delayed-type hypersensitivity, Aust. J. Exp. Biol. Med. Sci. 46: 33–49.PubMedGoogle Scholar
  138. Nelson, D. S., Kossard, S., Cox, P. E., 1967, Heterogeneity of macrophage cytophilic antibodies in immunized mice, Experientia 23: 490–491.Google Scholar
  139. Nickerson, D. S., Kazmierowski, J. A., Dossett, J. H., Williams, R. C., Jr., Quie, P. G., 1969, Studies of immune and normal opsonins during experimental staphylococcal infections in rabbits, J. Immunol. 102: 1235–1241.PubMedGoogle Scholar
  140. Nickerson, D. S., Williams, R. C., Jr., Boxmeyer, M., Quie, P. G., 1970, Increased opsonic capacity of serum in chronic heroin addiction, Ann. Intern. Med. 72: 671–677.PubMedGoogle Scholar
  141. Nilsson, U. R., Miller, M. E., Wyman, S., 1974, A functional abnormality of the fifth component of complement (C5) from human serum of individuals with a familial opsonic defect, J. Immunol. 112: 1164–1176.PubMedGoogle Scholar
  142. van Oss, C. J., Singer, J. M., 1966, The binding of immune globulins and other proteins by polystyrene latex particles, J. Reticuloendothel. Soc. 3: 29–40.PubMedGoogle Scholar
  143. van Oss, C. J., Stinson, M. W., 1970, Immunoglobulins as aspecific opsonins. I. The influence of polyclonal and monoclonal immunoglobulins on the in vitro phagocytosis of latex particles and staphylococci by human neutrophils, J. Reticuloendothel. Soc. 8: 397–406.PubMedGoogle Scholar
  144. Parish, W. E., 1965, Differentiation between cytophilic antibody and opsonin by a macrophage phago-cytic system, Nature London 108: 594–595.Google Scholar
  145. Pearlman, D. S., Ward, P. A., Becker, E. L., 1969, The requirement of serine esterase function in complement-dependent erythrophagocytosis, J. Exp. Med. 130: 745–764.PubMedGoogle Scholar
  146. Phillips, J. K., Snyderman, R., Mergenhagen, S. E., 1972, Activation of complement by endotoxin: a role for γl globulin, Cl, C4 and C2 in the consumption of terminal complement components by endotoxin-treated erythrocytes, J. Immunol. 109: 334–341.PubMedGoogle Scholar
  147. Phillips-Quagliata, J. M., Levine, B. B., Quagliata, F., Uhr, J. W., 1971, Mechanisms underlying binding of immune complexes to macrophages, J. Exp. Med. 133: 589–601.PubMedGoogle Scholar
  148. Pillemer, L., Blum, L., Lepow, I. H., Ross, O. A., Todd, E. W., Wardlaw, A. C., 1954, The properdin system in immunity: I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena, Science 120: 279–285.PubMedGoogle Scholar
  149. Quie, P. G., Messner, R. P., Williams, R. C., Jr., 1968, Phagocytosis in subacute bacterial endocarditis. Localization of the primary opsonic site to Fc fragment, J. Exp. Med. 128: 553–570.PubMedGoogle Scholar
  150. Rabinovitch, M., 1967, Studies on immunoglobulins which stimulate the ingestion of glutaraldehyde- treated red cells attached to macrophages, J. Immunol. 99: 1115–1120.PubMedGoogle Scholar
  151. Ralston, D. J., Elberg, S. S., 1969, Serum-mediated immune cellular responses to Brucella melitensis REVI. II. Restriction of Brucella by immune sera and macrophages, J. Reticuloendothel. Soc. 6: 109–139.PubMedGoogle Scholar
  152. Reed, W. P., 1975, Serum factors capable of opsonizing Shigella for phagocytosis by polymorphonuclear neutrophils, Immunology 28: 1051–1059.PubMedGoogle Scholar
  153. Reynolds, H. Y., Thompson, R. E., 1973, Pulmonary host defenses. II. Interaction of respiratory antibodies with Pseudomonas aeruginosa and alveolar macrophages, J. Immunol. 111: 369–380.PubMedGoogle Scholar
  154. Rhodes, J., 1973, Receptor for monomelic IgM on guinea-pig splenic macrophages, Nature London 243: 527–528.PubMedGoogle Scholar
  155. Robbins, J. B., Kenny, K., Suter, E., 1965, The isolation and biological activities of rabbit γM- and γG-anti-Salmonella typhimurium antibodies, J. Exp. Med. 122: 385–402.PubMedGoogle Scholar
  156. Roberts, R. B., 1967, The interaction in vitro between group B meningococci and rabbit polymorphonuclear leukocytes. Demonstration of type specific opsonins and bactericidins, J. Exp. Med. 126: 795–817.PubMedGoogle Scholar
  157. Roberts, R. B., 1970, The relationship between group A and group B meningococcal polysaccharides and 111 serum opsonins in man, J. Exp. Med. 131: 499–513.PubMedGoogle Scholar
  158. Root, R. K., Ellman, L., Frank, M. M., 1972, Bactericidal and opsonic properties of C4-deficient guinea pig serum, J. Immunol. 109: 477–486.PubMedGoogle Scholar
  159. Rosen, F. S., Janeway, C. A., 1966, The gammaglobulins. III. The antibody deficiency syndromes, N. Engl. J. Med. 275: 709–715.PubMedGoogle Scholar
  160. Rosenfeld, S. I., Leddy, J. P., 1974, Hereditary deficiency of fifth component of complement (C5) in man, J. Clin. Invest. 53: 67a.Google Scholar
  161. Ross, G. D., Polley, M. J., 1975, Specificity of human lymphocyte complement receptors, J. Exp. Med. 141: 1163–1180.PubMedGoogle Scholar
  162. Rothbard, S., 1945, Bacteriostatic effect of human sera on group A streptococci. II. Comparative bacteriostatic effect of normal whole blood from different animal species in the presence of human convalescent sera, J. Exp. Med. 82: 107–118.PubMedGoogle Scholar
  163. Rowley, D., 1958, Bactericidal activity of macrophages in vitro against Escherichia coli, Nature London 181: 1738–1739.PubMedGoogle Scholar
  164. Rowley, D., Turner, K. J., 1966, Number of molecules of antibody required to promote phagocytosis of one bacterium, Nature London 210: 496–498.PubMedGoogle Scholar
  165. Rowley, D., Turner, K. J., Jenkin, C. R., 1964, The basis for immunity to mouse typhoid. 3. Cell- bound antibody, Aust. J. Exp. Biol. Med. Sci. 42: 237–248.PubMedGoogle Scholar
  166. Ruddy, S., Austen, K. F., 1969, C3 inactivator of man. I. Hemolytic measurement by the inactivation of cell-bound C3, J. Immunol. 102: 533–543.PubMedGoogle Scholar
  167. Ruddy, S., Austen, K. F., 1971, C3b inactivator of man. II. Fragments produced by C3b inactivator cleavage of cell-bound or fluid phase C3b, J. Immunol. 107: 742–750.PubMedGoogle Scholar
  168. Ruddy, S., Klemperer, M. R., Rosen, F. S., Austen, K. F., Kumate, J., 1970, Hereditary deficiency of the second component of complement (C2) in man: correlation of C2 haemolytic activity with immunochemical measurements of C2 protein, Immunology 18: 943–954.PubMedGoogle Scholar
  169. Sandberg, A. L., Osier, A. G., 1971, Dual pathways of complement interaction with guinea pig immunoglobulins, J. Immunol. 107: 1268–1273.PubMedGoogle Scholar
  170. Sandberg, A. L., Oliveira, B., Osier, A. G., 1971a, Two complement interaction sites in guinea pig immunoglobulins, J. Immunol. 106: 282–285.PubMedGoogle Scholar
  171. Sandberg, A. L., Götze, O., Muller-Eberhard, H. J., Osier, A. G., 1971b, Complement utilization by guinea pig γl and γ2 immunoglobulins through the C3 activator system, J. Immunol. 107: 920–923.PubMedGoogle Scholar
  172. Schreiber, A. D., Frank, M. M., 1972a, Role of antibody and complement in the immune clearance and destruction of erythrocytes. I. In vivo effects of IgG and IgM complement-fixing sites, J. Clin. Invest. 51: 575–582.Google Scholar
  173. Schreiber, A. D., Frank, M. M., 1972b, Role of antibody and complement in the immune clearance and destruction of erythrocytes. II. Molecular nature of IgG and IgM complement-fixing sites and effects of their interaction with serum, J. Clin. Invest. 51: 583–589.PubMedGoogle Scholar
  174. Schur, P. H., Becker, E. L., 1963, Pepsin digestion of rabbit and sheep antibodies: the effect on complement fixation, J. Exp. Ed. 118: 891–904.Google Scholar
  175. Shayegani, M. G., Mudd, S., 1966, Role of serum in the intracellular killing of staphylococci in rabbit monocytes, J. Bacteriol. 91: 1393–1398.PubMedGoogle Scholar
  176. Shin, H. S., Smith, M. R., Wood, W. B., Jr., 1969, Heat labile opsonins to pneumococcus. II. Involvement of C3 and C5, J. Exp. Med. 130: 1229–1241.PubMedGoogle Scholar
  177. Siegel, J., Rent, R., Gewurz, H., 1974, Interaction of C-reactive protein with the complement system. I. Protamine-induced consumption of complement in acute phase sera, J. Exp. Med. 140: 631–647.PubMedGoogle Scholar
  178. Silverstein, A. M., 1960, Essential hypocomplementemia: report of a case, Blood 16: 1338–1341.PubMedGoogle Scholar
  179. Silverstein, S. C., Castle, D., 1970, The effect of antibody on the phagocytosis and processing of vaccinia virus by mouse peritoneal macrophages, J. Cell Biol. 47: 192a.Google Scholar
  180. Smith, J. W., Barnett, J. A., May, R. P., Sanford, J. P., 1967, Comparison of the opsonic activity of γ-G- and γ-M-anti-proteus globulins, J. Immunol. 98: 336–343.PubMedGoogle Scholar
  181. Smith, M. A., Cooper, M. D., Wollheim, F. A., Hong, R., Good, R. A., 1966, The IgA system. I. Studies of the transport and immunochemistry of IgA in the saliva, J. Exp. Med. 123: 615–627.Google Scholar
  182. Smith, M. R., Wood, W. B., Jr., 1969, Heat labile opsonins to pneumococcus. I. Participation of complement, J. Exp. Med. 130: 1209–1227.PubMedGoogle Scholar
  183. Smith, M. R., Shin, H. S., Wood, W. B., Jr., 1969, Natural immunity to bacterial infections: the relation of complement to heat-labile opsonins, Proc. Nat. Acad. Sci. U.S.A. 63: 1151–1156.Google Scholar
  184. Sorkin, E., 1963, Cytophilic antibody, in: Ciba Found. Symp., The Immunologically Competent Cell ( G. E. W. Wolstenholme and M. P. Cameron, eds.), p. 53, Churchill, London.Google Scholar
  185. Speigelberg, H. L., Miescher, P. A., Benacerraf, B., 1963, Studies on the role of complement in the JR- immune clearance of Escherichia coli and rat erythrocytes by the reticuloendothelial system in mice, J. Immunol. 90: 751–759.Google Scholar
  186. Steinman, R. M., Cohn, Z. A., 1972, The interaction of particulate horseradish peroxidase (HRP)- anti HRP immune complexes with mouse peritoneal macrophages in vitro, J. Cell Biol. 55: 616–634.PubMedGoogle Scholar
  187. Stinson, M. W., van Oss, C. J., 1971, Immunoglobulins as aspecific opsonins. II. The influence of specific and aspecific immunoglobulins on the in vitro phagocytosis of nonencapsulated, capsulated, and decapsulated bacteria by human neutrophils, J. Reticuloendothel. Soc. 9: 503–512.PubMedGoogle Scholar
  188. Stollerman, G. H., Rytel, M., Ortiz, J., 1963, Accessory plasma factors involved in the bactericidal test for type-specific antibody to group A streptococci. II. Human plasma cofactors(s) enhancing opsonization of encapsulated organisms, J. Exp. Med. 117: 1–17.PubMedGoogle Scholar
  189. Stollerman, G. H., Alberti, H., Plemmons, J. A., 1967, Opsonization of group A streptococci by complement deficient Blood from a patient with hereditary angioneurotic edema, J. Immunol. 99: 92–97.PubMedGoogle Scholar
  190. Stossel, T. P., 1973, Quantitative studies on phagocytosis. Kinetic effects of cations and heat-labile opsonins, J. Cell Biol. 58: 346–356.PubMedGoogle Scholar
  191. Stossel, T. P., Pincus, S. H., 1975, A new macrophage actin-binding protein: evidence for its role in endocytosis, Clin. Res. 23: 407A.Google Scholar
  192. Stossel, T. P., Alper, C. A., Rosen, F. S., 1973a, Serum-dependent phagocytosis of paraffin oil emulsified with bacterial lipopolysaccharide, J. Exp. Med. 137: 690–705.PubMedGoogle Scholar
  193. Stossel, T. P., Alper, C. A., Rosen, F. S., 1973b, Opsonic activity in the newborn: Role of properdin, Pediatrics 52: 134–137.PubMedGoogle Scholar
  194. Stossel, T. P., Field, R. J., Gitlin, J. D., Alper, C. A., Rosen, F. S., 1975, The opsonic fragment of the third component of human complement (C3), J. Exp. Med. 141: 1329–1347.PubMedGoogle Scholar
  195. Tizard, I. R., 1969, Macrophage cytophilic antibody in mice. Differentiation between antigen adherence due to these antibodies and opsonic adherence, Int. Arch. Allergy Appl. Immunol. 36: 332–346.PubMedGoogle Scholar
  196. Tizard, I. R., 1971, Macrophage cytophilic antibodies in mice: the adsorption of cytophilic antibodies from solution by mouse peritoneal cells and cooperative interaction between receptors for immu-noglobulin, J. Reticuloendothel, Soc. 10: 449–460.Google Scholar
  197. Turner, K. J., Rowley, D., 1963, Opsonins in pig serum and their purification, Aust. J. Exp. Biol. Med. Sci. 41: 595–613.PubMedGoogle Scholar
  198. Uhr, J. W., 1965, Passive sensitization of lymphocytes and macrophages by antigen-antibody complexes, Proc. Nat. Acad. Sci. U.S.A. 54: 1599–1606.Google Scholar
  199. Valentine, R. C., Green, N. M., 1967, Electron microscopy of an antibody-hapten complex, J. Mol. Biol. 27: 615–617.PubMedGoogle Scholar
  200. Ward, H. K., Enders, J. F., 1933, An analysis of the opsonic and tropic action of normal and immune sera based on experiments with the pneumococcus, J. Exp. Med. 57: 527–547.PubMedGoogle Scholar
  201. Warner, C., Schumaker, V., Karush, F., 1970, The detection of a conformational change in the antibody molecule upon interaction with hapten, Biochem. Biophys. Res. Commun. 38: 125–128.PubMedGoogle Scholar
  202. Wheat, L. J., Humphreys, D. W., White, A., 1974, Opsonization of staphylococci by normal human sera: the role of antibody and heat-labile factors, J. Lab. Clin. Med. 83: 73–78.PubMedGoogle Scholar
  203. Williams, R. C., Jr., Quie, P. G., 1968, Studies of human C-reactive protein in an in vitro phagocytic system, J. Immunol. 101: 426–432.PubMedGoogle Scholar
  204. Williams, R. C., Jr., Quie, P. G., 1971, Opsonic activity of agammaglobulinemic human sera, J. Immunol. 106: 51–55.PubMedGoogle Scholar
  205. Williams, R. C., Jr., Dossett, J. H., Quie, P. G., 1969, Comparative studies of immunoglobulin opsonins in osteomyelitis and other established infections, Immunology 17: 249–265.PubMedGoogle Scholar
  206. Wilson, I. D., 1972, Studies on the opsonic activity of human secretory IgA using an in vitro pahgocytosis system, J. Immunol. 108: 726–730.PubMedGoogle Scholar
  207. Winkelstein, J. A., Drachman, R. H., 1968, Deficiency of pneumococcal opsonizing activity in sickle- cell disease, N. Engl. J. Med. 279: 459–466.PubMedGoogle Scholar
  208. Winkelstein, J. A., Shin, H. S., 1974, The role of immunoglobulin in the interaction of pneumococci and the properdin pathway: evidence for its specificity and lack of requirement for the Fc portion of the molecule, J. Immunol. 112: 1635–1642.PubMedGoogle Scholar
  209. Winkelstein, J. A., Shin, H. S., Wood, W. B., Jr., 1972, Heat labile opsonins to pneumococcus. III. The participation of immunoglobulin and of the alternate pathway of C3 activiation, J. Immunol. 108: 1681–1689.PubMedGoogle Scholar
  210. Woodin, A. M., 1974, Action of organophosphorus compounds on the p-nitrophenyl phosphatase of 113 membranes from rabbit and guinea pig polymorphonuclear leucocytes, Exp. Cell Res. 89: 15–22.PubMedGoogle Scholar
  211. Wright, A. E., Douglas, S. R., 1903, An experimental investigation of the role of the body fluids in connection with phagocytosis, Proc. R. Soc. London 72: 357–370.Google Scholar
  212. Wu, W. G., Marcus, S., 1963, Humoral factors in cellular resistance. I. The effects of heated and unheated homologous and heterologous sera on phagocytosis and cytopepsis by normal and “immune” macrophages, J. Immunol. 91: 313–322.PubMedGoogle Scholar
  213. Wu, W. G., Marcus, S., 1964, Humoral factors in cellular resistance. II. The role of complement and properdin in phagocytosis and cytopepsis by normal and “immune” macrophages, J. Immunol. 92: 397–403.PubMedGoogle Scholar
  214. Young, L. S., 1972, Human immunity to Pseudomonas aeruginosa. II. Relationship between heat-stable opsonins and type-specific lipopolysaccharides, J. Infect. Dis. 126: 277–287.PubMedGoogle Scholar
  215. Young, L. S., Armstrong, D., 1972, Human immunity to Pseudomonas aeruginosa. I. In-vitro interaction of bacteria, polymorphonuclear leukocytes, and serum factors, J. Infect. Dis. 126: 257–276.PubMedGoogle Scholar
  216. Ziegler, J. ?., Alper, C. A., Rosen, F. S., Lachmann, P. J., Sherington, L., 1975, Restoration by purified C3b inactivator of complement-mediated function in vivo in a patient with C3b inactivator deficiency, J. Clin. Invest. 55: 668–672.Google Scholar
  217. Zinsser, H., Enders, J. F., Fothergill, L., 1939, The phenomenon of phagocytosis, in: Immunity, Principles and Applications in Medicine and Public Health, pp. 317–319, Macmillan Co., New York.Google Scholar
  218. Zipursky, A., Brown, E. J., Bienenstock, J., 1973, Lack of opsonization potential of 11 S human secretory γA, Proc. Soc. Exp. Biol. Med. 142: 181–184.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Frank M. GriffinJr.
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA

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