Complement Synthesis

  • Harvey R. Colten
Part of the Comprehensive Immunology book series (COMIMUN, volume 2)


In the past two decades, considerable progress has been made in the study of complement biosynthesis, following the isolation and characterization of the individual components of complement, the design of suitable immunochemical and functional assays for complement proteins, and improvements in tissue- and organ- culture techniques. These advances have made it possible to identify the sites of synthesis of most of the complemment proteins and, more recently with these methods, an approcah to questions of more general biological interest has been possible. Genetic variants of complement proteins have been recognized and well-defined deficiencies of complement have been described in humans and experimental animals, providing excellent models for studies of genetic control of protein synthesis. In addition, changes in serum complement resulting from the acute phase response or in specific autoimmune diseases have raised important general questions about the control of plasma protein metabolism, which can be approached with current methods. One purpose of this chapter is to emphasize these actual and potential applications of studies of complement biosynthesis.


Complement Component Complement Protein Peritoneal Cell Fourth Component Membranoproliferative Glomerulonephritis 
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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Harvey R. Colten
    • 1
    • 2
  1. 1.Division of Allergy, Department of MedicineChildren’s Hospital Medical CenterBostonUSA
  2. 2.Department of PediatricsHarvard Medical SchoolBostonUSA

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