Perturbations of Complement in Disease

  • Irma Gigli
Part of the Comprehensive Immunology book series (COMIMUN, volume 2)


Alterations in the complement (C) system in human pathology have been recognized for many years, but only within recent years have measurements of serum C components become clinically available. In view of the apparent different biological properties of each component of the C system (Ruddy et al., 1972a; Müller-Eberhard, 1975), a proper understanding of the role of C in disease requires an analysis not only of the whole hemolytic C, but also of its components. Immunochemical measurements using monospecific antibodies against C proteins are available, but fail to distinguish between native proteins and those that have been rendered inactive either because they have participated in the C reaction sequence or because they have been incorrectly synthesized de novo. Stoichiometric hemolytic titrations provide sensitive assessment of the functional activity of the individual C component.


Systemic Lupus Erythematosus Paroxysmal Nocturnal Hemoglobinuria Bullous Pemphigoid Dengue Hemorrhagic Fever Hereditary Angioedema 
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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Irma Gigli
    • 1
    • 2
  1. 1.Department of DermatologyNew York University Medical CenterNew YorkUSA
  2. 2.Department of MedicineNew York University Medical CenterNew YorkUSA

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