Isolated Deficiencies of the Complement System in Experimental Animals

  • Hartmut Geiger
  • Noorbibi K. Day
Part of the Comprehensive Immunology book series (COMIMUN, volume 2)


In addition to the genetic deficiencies of complement (C) components in man, genetically transmitted or experimentally induced deficiencies of individual components of the С system have been described in animals of various species (Table 1). These animals provide a useful model for study of the requirement of complement activation by both the classical and alternative pathway for immune reactions and defense mechanisms in vivo and in vitro.


Chemotactic Activity Deficient Animal Arthus Reaction Immune Adherence Deficient Serum 
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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Hartmut Geiger
    • 1
  • Noorbibi K. Day
    • 2
  1. 1.Universitäts-KinderklinikHeidelbergGermany
  2. 2.Sloan-Kettering Institute for Cancer ResearchNew YorkUSA

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