Immunoengineering: Prospects for Correction of Age-Related Immunodeficiency States

  • Roy L. Walford
  • Patricia J. Meredith
  • Kay E. Cheney
Part of the Comprehensive Immunology book series (COMIMUN, volume 1)


The term immunoengineering in the context used here refers to procedures that may serve to ameliorate the immunologic abnormalities associated with aging. Such amelioration would be important for both theoretical and practical reasons. From the standpoint of theory, it has been repeatedly emphasized that the only valid test of an aging hypothesis requires significant extension of the life span of long-lived strains of animals, including extension of the longest-lived or tenth decile survivorship (Walford, 1969, 1974). Considered in these terms, life span cannot be extended merely by eliminating specific diseases (Strehler, 1975). A major extension of longest-lived survivorship by measures that can only be interpreted immunologically would constitute formal proof of the immunologic theory of aging, at least in terms of pathogenesis (Walford, 1974).


Bone Marrow Cell Spleen Cell Primary Immunodeficiency Disease Lymphoid System Thymic Hormone 
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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Roy L. Walford
    • 1
  • Patricia J. Meredith
    • 1
  • Kay E. Cheney
    • 1
  1. 1.Department of PathologyUCLA School of MedicineLos AngelesUSA

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