Autoimmunity to Receptors as a Possible Cause of Multiple Sclerosis

  • P. R. Carnegie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 100)


The concept that chronic disease could result from an immune response to cell surface receptors (3) has been supported by the demonstration of an immune response to acetylcholine receptor in myasthenia gravis, thyroid stimulating hormone receptor in Graves’ disease, insulin receptor in insulin resistant diabetes, prolactin receptor in animals immunized with the receptor (for references, see review, 2). While binding assays have been used to demonstrate antibody to receptors, more definitive results were often obtained with physiological assays.


Multiple Sclerosis Insulin Receptor Acetylcholine Receptor Cell Surface Receptor Experimental Allergic Encephalomyelitis 
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    Carnegie, P.R., Properties, structure and possible neuroreceptor role of the encephalitogenic protein of human myelin, Nature 229 (1971) 25–28.PubMedCrossRefGoogle Scholar
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    Carnegie, P.R. and Mackay, I.R., Vulnerability of cell surface receptors to autoimmune reactions, Lancet 2 (1975) 681–686.Google Scholar
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    Lennon, V.A. and Carnegie, P.R., Immunopharmacological disease: a break in tolerance to receptor sites, Lancet 1 (1971) 630–633.PubMedCrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • P. R. Carnegie
    • 1
  1. 1.School of BiochemistryUniversity of MelbourneParkvilleAustralia

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