Autoimmunity to Receptors as a Possible Cause of Multiple Sclerosis
The concept that chronic disease could result from an immune response to cell surface receptors (3) has been supported by the demonstration of an immune response to acetylcholine receptor in myasthenia gravis, thyroid stimulating hormone receptor in Graves’ disease, insulin receptor in insulin resistant diabetes, prolactin receptor in animals immunized with the receptor (for references, see review, 2). While binding assays have been used to demonstrate antibody to receptors, more definitive results were often obtained with physiological assays.
KeywordsMultiple Sclerosis Insulin Receptor Acetylcholine Receptor Cell Surface Receptor Experimental Allergic Encephalomyelitis
- 2.Carnegie, P.R. and Mackay, I.R., Vulnerability of cell surface receptors to autoimmune reactions, Lancet 2 (1975) 681–686.Google Scholar