Biochemical Study on Myelin in Adrenoleukodystrophy
Two myelin fractions, heavy and light, were isolated from white matter of a patient with adrenoleukodystrophy. Morphologically, heavy myelin fraction showed compact lamellar structures, and light myelin fraction consisted of loose lamellar structures and rod-like clear space. Analytical studies demonstrated that the chemical composition of heavy myelin fraction was almost the same as that of normal myelin and that light myelin fraction consisted mainly of cholesterol. Long chain saturated fatty acids, C25:0 and C26:0 were increased and C24:1 was decreased in sphingoglycolipids of heavy myelin fraction of the patient.
KeywordsWhite Matter Hydroxy Fatty Acid Cerebral White Matter Sucrose Density Gradient Frontal White Matter
Unable to display preview. Download preview PDF.
- 2.Ariga, T., in preparation.Google Scholar
- 14.Ogino, T. and Yokoi, S., Studies on sphingoglycolipid of the brain of three adult cases of leukodystrophy, Folia Psychiatr. Neurol. Japon. 28 (1974) 207–215.Google Scholar
- 22.Vance, D.E. and Sweeley, C.C., Quantitative determination of the neutral glycosyl ceramides in human blood, J. Lipid Res. 8 (1967) 391–395.Google Scholar