Summary
Lymphocytes present in the brain, meninges and cerebrospinal fluid (CSF) in multiple sclerosis (MS) are capable of synthesizing IgG. The CSF in MS contains more T-lymphocytes and fewer B-lymphocytes compared to blood. The reactivity of CSF lymphocytes in MS to T-cell mitogens and probably also to a combined B-and T-cell mitogen is absent or heavily reduced. This unresponsiveness of CSF lymphocytes may be a consequence of their previous activation. The blood lymphocytes in MS are not altered regarding distribution of B-and T-cells, nor regarding responsiveness to mitogens, when compared with healthy controls. An asynchronous synthesis of heavy and light immunoglobulin chains occurs within the CNS in many MS patients, giving rise to oligoclonal band patterns on electrophoresis and abnormal kappa/lambda light chain ratios of CSF.
The synthesized immunoglobulins are most probably antibodies which may play a role in the pathogenesis and course of human demyelinating diseases. The brain must be regarded, from an immunological point of view, as a privileged site with its own immune system and its characteristic immune reactions, and future research concerning demyelinating diseases should, if possible, include investigations of these reactions.
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References
Adams, C.W.M., Pathology of multiple sclerosis: progression of the lesion, Brit. Med. Bull. 33 (1977) 15–20.
Brown, P., Cathala, F., Gajdusek, D.C. and Gibbs, C.J., Measles antibodies in the cerebrospinal fluid of patients with multiple sclerosis, Proc. Soc. Exp. Biol. Med. 137 (1971) 956–961.
Felgenhauer, K., Protein size and cerebrospinal fluid composition, Klin. Wschr. 52 (1971+) 1158–1164.
Frick, E. and Scheid-Seydel, L., Untersuchungen mit J131-markiertem y-Globulin zur Frage der Abstammung der Liquoreiweisskörper, Klin. Wschr. 36 (1958) 857-863.
Frydén, A. and Link, H., Mitogen stimulation of cerebrospinal fluid lymphocytes in aseptic meningitis, Acta Neurol. Scandinay. submitted for publication (1977).
Kabat, E.A., Moore, D.H. and Landow, H., An electrophoretic study of the protein components in cerebrospinal fluid and their relationship to the serum proteins, J. Clin. Invest. 21 (1942) 571–577.
Kam-Hansen, S., Frydén, A. and Link, H., Lymphocyte sub-populations and the effect of mitogen stimulation in multiple sclerosis, Acta Neurol. Scandinay., submitted for publication (1977).
Laterre, E.C., Callewaert, A. and Heremans, J.F., Electrophoretic morphology of gammaglobulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system, Neurology 20 (1970) 982–990.
Laurell, C.B., Determination and interpretation of plasma proteins, Austr. Fam. Phys. 5 (1976) 36–41.
Link, H., Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid: Chemical and immunological characterisation with special reference to multiple sclerosis,Acta Neurol. Scandinay. 43, Suppl. 28 (1967) 1–136.
Link, H., Oligoclonal immunoglobulin G in multiple sclerosis brains, J. neurol. Sci. 16 (1972) 103–114.
Link, H., Demonstration of oligoclonal immunoglobulin G in Guillain-Barré syndrome, Acta Neurol. Scandinay. 52 (1975) 111–120.
Link, H. and Müller, R., Immunoglobulins in multiple sclerosis and infections of the nervous system, Arch. Neurol. 25 (1971) 326–344.
Link, H., Panelius, M. and Salmi, A.A., Immunoglobulins and measles antibodies in subacute sclerosing panencephalitis, Arch. Neurol. 28 (1973) 23-30.
Link, H. and Tibbling, G., Principles of albumin and IgG analyses in neurological disorders. II. Relation of the concentration of the proteins in serum and cerebrospinal fluid, Scand. J. Lab. Clin. Invest., in press.
Link, H. and Tibbling, G., Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis, Scand. J. Lab. Clin. Invest., in press.
Link, H. and Zettervall, 0., Multiple sclerosis: disturbed kappa:lambda chain ratio of immunoglobulin G in cerebrospinal fluid, Clin. exp. Immunol. 6 (1970) 435–438.
Norrby, E., Link, H. and Olsson, J.-E., Measles virus antibody titers in cerebrospinal fluid and serum from patients with multiple sclerosis and controls, Arch. Neurol. 30 (1974) 285–292.
Norrby,E.,Link, H.,Olsson,J.-E.,Panelius,M.,Salmi,A.and Vandvik,B.,Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis, Infection and Immunity 10 (1974) 688694.
Olsson, J.-E. and Link, H., Immunoglobulin abnormalities in multiple sclerosis. Relation to clinical parameters. Exacerbations and remissions, Arch. Neurol. 28 (1973) 392-399.
Olsson, J.-E., Link, H. and Müller, R., Immunoglobulin abnormalities in multiple sclerosis, J. neurol. Sci. 27 (1976) 233–245.
Sandberg-Wollheim, M., Immunoglobulin synthesis in vitro by cerebrospinal fluid cells in patients with multiple sclerosis, Scand. J. Immunol. 3 (1974) 717–730.
Sandberg-Wollheim, M. and Turesson, I., Lymphocyte subpopulations in the cerebrospinal fluid and peripheral blood in patients with multiple sclerosis, Scand. J. Immunol. 4 (1975) 831–836.
Tibbling, G., Link, H. and Obman, S., Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values, Scan. J. Clin. Invest., in press.
Tourtellotte, W.W., Multiple sclerosis research, in Proceedings of a joint conference held by the Medical Research Council and the Multiple Sclerosis Society of Great Britain and Northern Ireland, 17–18 October 1974 (A.N. Davison, J.H. Humphrey, L.H. Liversedge, W.J. McDonald and J.S. Porterfield, eds.) HMSO, London (1975) pp. 9-26.
Vandvik, B., Natvig, J.B. and Wiger, D., IgG, subclass restriction of oligoclonal IgG from cerebrospinal fluids and brainextracts in patients with multiple sclerosis and subacute encephalitides, Scand. J. Immunol. 5 (1976) )427-436.
Vandvik, B., Norrby, E., Nordal, H.J. and Degré, M., Oligoclonal measles virus-specific IgG antibodies isolated from cerebrospinal fluids, brain extracts, and sera from patients with subacute sclerosing panencephalitis and multiple sclerosis, Scand. J. Immunol. 5 (1976) 979–992.
Yahr, M.D., Goldensohn, S.S. and Kabat, E.A., Further studies on the gamma globulin content of cerebrospinal fluid in multiple sclerosis and other neurological disorders, Ann. N.Y. Acad.Sci. 58 (1954) 613–624
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Link, H. (1978). The Immune Response in Human Demyelinating Diseases. In: Palo, J. (eds) Myelination and Demyelination. Advances in Experimental Medicine and Biology, vol 100. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2514-7_39
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DOI: https://doi.org/10.1007/978-1-4684-2514-7_39
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