Cerebrospinal Fluid Myelin Basic Protein and Multiple Sclerosis
We have previously reported that myelin basic protein appears in CSF during acute attacks of multiple sclerosis. These studies have been extended to over 700 patients, 91 with multiple sclerosis. The data continues to indicate that myelin basic protein is released into cerebrospinal fluid during acute attacks of multiple sclerosis. We are currently characterizing the basic protein in the CSF.
KeywordsMultiple Sclerosis Multiple Sclerosis Patient Myelin Basic Protein Basic Protein Optic Neuritis
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- 1.Cohen, S.R. and Guarnieri, M., Immunochemical measurement of myelin basic protein in developing rat brain: An index of myelin synthesis, Devel. Bio1.49 (1976) 294–299.Google Scholar
- 2.Cohen, S.R., Herndon, R.M. and McKhann, G.M., Radioimmunoassay of myelin basic protein in spinal fluid: An index of active demyelination, New Engl. J.Med.295 (1976) 1455–1457.Google Scholar
- 5.Lennon, V. and Macay I.R., Binding of 1251 myelin basic protein by serum and cerebrospinal fluid, Clin. Exp. Immunol. 11 (1972) 595–603.Google Scholar
- 6.McPherson, T.A., Gilpin, A. and Seloved, T.P., Radioimmunoassay of CSF for encephalitogenic basic protein: A diagnostic test for MS?, Canad. Med. Assoc. J. 4 (1972) 856–859.Google Scholar