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Abnormal Myelin Maturation In Vitro: the Role of Cerebrosides

  • Keith Bradbury
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 100)

Summary

Myelinating neonatal rat cerebellar explants were maintained for up to 130 days in vitro. Myelin fractions were extracted from explants of different ages and purified by density gradient centrifugation. The three fractions obtained were termed “light myelin”, “heavy myelin” and “membrane fraction” and were deficient in glycolipids compared to myelin fractions prepared from 15-day-old rat cerebellum. The culture myelin has an apparently normal ultra-structure but may not be as stable as myelin with a normal glycolipid composition.

Keywords

Multiple Sclerosis Membrane Fraction Myelinated Axon Myelin Membrane Chick Embryo Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Keith Bradbury
    • 1
  1. 1.Department of PathologyUniversity of LeedsLeedsEngland

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