Problems in the Treatment of Parkinsonism

  • Roger C. Duvoisin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 90)


The progress achieved in our understanding of parkinsonism and its treatment in the last decade has greatly improved the lot of our patients but has also brought new sets of problems. The very effectiveness of levodopa therapy has modified the clinical spectrum of symptomatology. By suppressing tremor and rigidity and prolong ing our patients’ lives, we have uncovered other manifestations of parkinsonism which were previously less prominent. The greater specificity of levodopa has rendered precise diagnosis more important, but at the same time the recognition of new entities has changed the nosology of parkinsonism. Although the diagnosis of extrapyramidal disorders depends almost exclusively on clinical observation, new diagnostic tools are beginning to alter the character of neurology and promise to have a significant impact on the clinical evaluation of patients with basal ganglia diseases.

Our better understanding of the modus operands of various drugs used in treating extrapyramidal disorders has in some ways complicated the physician’s task. In place of the simple empiricism that prevailed a decade ago, there is now a body of knowledge and theory which one must appreciate to obtain optimal therapeutic results.

The remarkable relief of Parkinsonian symptomatology possible in some patients has thrown into relief cases of treatment failure and placed additional emphasis on manifestations of parkinsonism which are either unresponsive to therapy or are actually exacer-bated by it. Finally, the diagnosis and management of intercurrent illnesses in Parkinson patients on levodopa therapy has presented additional new problems to the clinician.


Essential Tremor Anticholinergic Agent Levodopa Therapy Normal Pressure Hydrocephalus Intercurrent Illness 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Roger C. Duvoisin
    • 1
  1. 1.Department of Neurology, The Mount Sinai School of MedicineThe City University of New YorkNew YorkUSA

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